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pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
pH-dependent pressure-sensitive colonic capsules for the delivery of aqueous bacterial suspensions
Microbiome-based therapies hold great promise for treating various diseases, but the efficient delivery of live bacteria t...
A radioactive CRISPR interference system using 89Zr-labeled LbCas12a
A radioactive CRISPR interference system using 89Zr-labeled LbCas12a
Recently, CRISPR proteins have been recognized as promising candidates for drug development. However, there is still a lac...
Antigen-specific T cell activation through targeted delivery of in-situ generated antigen and calcium ionophore to enhance antitumor immunotherapy
Antigen-specific T cell activation through targeted delivery of in-situ generated antigen and calcium ionophore to enhance antitumor immunotherapy
Current cancer immunotherapy primarily focuses on the activation of T cells to initiate an immune response. The sustained ...
MicroRNA-195 liposomes for therapy of Alzheimer's disease
MicroRNA-195 liposomes for therapy of Alzheimer's disease
Alzheimer's disease (AD) is a progressive disorder that starts with mild memory impairment and eventually results in a sev...
Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma
Effective delivery of miR-511-3p with mannose-decorated exosomes with RNA nanoparticles confers protection against asthma
Our previous studies have shown that miR-511-3p treatment has a beneficial effect in alleviating allergic airway inflammat...
Co-delivery of oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin for chemo-immunotherapy of orthotopic bladder cancer
Co-delivery of oxaliplatin prodrug liposomes with Bacillus Calmette-Guérin for chemo-immunotherapy of orthotopic bladder cancer
Bladder cancer (BC) is a prevalent and costly malignancy among urinary carcinomas globally, primarily due to the need for ...
Fish oil-based microemulsion can efficiently deliver oral peptide blocking PD-1/PD-L1 and simultaneously induce ferroptosis for cancer immunotherapy
Fish oil-based microemulsion can efficiently deliver oral peptide blocking PD-1/PD-L1 and simultaneously induce ferroptosis for cancer immunotherapy
In the past decade, significant advances have been made in cancer immunotherapy, demonstrating that the immune system, and...
Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
Micronanoparticled risedronate exhibits potent vaccine adjuvant effects
Bisphosphonates (BPs) are derivatives of inorganic pyrophosphate, characterized by a highly stable phosphorus‑carbon‑phosp...
Albumin hydrogels for repeated capture of drugs from the bloodstream and release into the tumor
Albumin hydrogels for repeated capture of drugs from the bloodstream and release into the tumor
Malignant tumors are one of the leading causes of death worldwide [1,2]. Surgery is often the primary treatment option, pa...
Harnessing astaxanthin-loaded diselenium cross-linked apotransferrin nanoparticles for the treatment of secretory otitis media
Harnessing astaxanthin-loaded diselenium cross-linked apotransferrin nanoparticles for the treatment of secretory otitis media
Secretory otitis media (SOM) is a type of non-suppurative inflammation of the middle ear characterized by tympanic effusio...
OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy
OX40L-expressing M1-like macrophage exosomes for cancer immunotherapy
Cancer immunotherapy represented by immune checkpoint target drugs has achieved significant success, providing hope to tho...
Hypoxia-activated glutamine antagonist prodrug combined with combretastatin A4 nanoparticles for tumor-selective metabolic blockade
Hypoxia-activated glutamine antagonist prodrug combined with combretastatin A4 nanoparticles for tumor-selective metabolic blockade
Glutamine is an essential nutrient for cell growth and proliferation, particularly for tumor cells [1]. Tumor cells are hi...
Impact of the physical-chemical properties of poly(lactic acid)–poly(ethylene glycol) polymeric nanoparticles on biodistribution
Impact of the physical-chemical properties of poly(lactic acid)–poly(ethylene glycol) polymeric nanoparticles on biodistribution
Over the last few decades, vast numbers of novel nanomedicines intended for delivering a range of therapeutic modalities h...
Engineered assemblies from isomeric pentapeptides augment dry eye treatment
Engineered assemblies from isomeric pentapeptides augment dry eye treatment
Dry eye disease (DED) is the most common ocular surface disease that affects about one third of the global population [1]....
Mucoadhesive chitosan microcapsules for controlled gastrointestinal delivery and oral bioavailability enhancement of low molecular weight peptides
Mucoadhesive chitosan microcapsules for controlled gastrointestinal delivery and oral bioavailability enhancement of low molecular weight peptides
Microencapsulation strategies of bioactive compounds have been studied to increase the loading capacity (LC), stability in...
Visualizing disintegration of 3D printed tablets in humans using MRI and comparison with in vitro data
Visualizing disintegration of 3D printed tablets in humans using MRI and comparison with in vitro data
KeywordsSelective laser sintering 3D printing of formulationsGastrointestinal disintegration of drug delivery systems and ...
Modeling the percutaneous absorption of solvent-deposited solids over a wide dose range: II. Weak electrolytes
Modeling the percutaneous absorption of solvent-deposited solids over a wide dose range: II. Weak electrolytes
The theory of finite dose absorption of pharmaceutical compounds following solvent deposition on skin has been addressed m...
CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy
CCL2 chemokine inhibition primes the tumor vasculature for improved nanomedicine delivery and efficacy
Efficient delivery of drugs to and into solid tumors is one of the key challenges of systemic anticancer therapy. Various ...
Targeted delivery of hybrid nanovesicles for enhanced brain penetration to achieve synergistic therapy of glioma
Targeted delivery of hybrid nanovesicles for enhanced brain penetration to achieve synergistic therapy of glioma
Over the past decades, liposome-based nano-drug delivery systems have demonstrated unique advantages in clinical tumor the...
Strategies for gaseous neuromodulator release in chemical neuroscience: Experimental approaches and translational validation
Strategies for gaseous neuromodulator release in chemical neuroscience: Experimental approaches and translational validation
Gasotransmitters, also known as gaseous neurotransmitters, are vital signaling molecules that are naturally produced in ma...
Pulmonary arterial hypertension nanotherapeutics: New pharmacological targets and drug delivery strategies
Pulmonary arterial hypertension nanotherapeutics: New pharmacological targets and drug delivery strategies
Pulmonary arterial hypertension (PAH) is a rare, severe, progressive disease characterized by high pressure in the lungs t...
Polymer mechanochemistry in drug delivery: From controlled release to precise activation
Polymer mechanochemistry in drug delivery: From controlled release to precise activation
A desired drug delivery system is expected to offer the diseased region with the required drug amount while preserving an ...
Remodeling of intestinal epithelium derived extracellular vesicles by nanoparticles and its bioeffect on tumor cell migration
Remodeling of intestinal epithelium derived extracellular vesicles by nanoparticles and its bioeffect on tumor cell migration
With oral nanomedicines widely applied in clinical trials and practice [1,2], clarifying the oral nano-bio interactions ar...
Multifunctional hydrogel for synergistic reoxygenation and chemo/photothermal therapy in metastatic breast cancer recurrence and wound infection
Multifunctional hydrogel for synergistic reoxygenation and chemo/photothermal therapy in metastatic breast cancer recurrence and wound infection
Breast cancer has become the most common malignancy among women worldwide [1]. Although it can be surgically removed for e...
Quantitative image analysis of intracellular protein translocation in 3-dimensional tissues for pharmacodynamic studies of immunogenic cell death
Quantitative image analysis of intracellular protein translocation in 3-dimensional tissues for pharmacodynamic studies of immunogenic cell death
A recent development in cancer chemotherapy is to use cytotoxics to induce tumor-specific immune response through immunoge...
Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer
Lipid-like gemcitabine diester-loaded liposomes for improved chemotherapy of pancreatic cancer
Gemcitabine (GEM) is a non-selective antitumor chemotherapeutic agent against pancreatic, breast, non-small cell lung, bla...
Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions
Mussel-inspired controllable drug release hydrogel for transdermal drug delivery: Hydrogen bond and ion-dipole interactions
Drug delivery system (DDS), which can release drugs at a specific rate and maintain the drug concentration at the target l...
Biofunctional coacervate-based artificial protocells with membrane-like and cytoplasm-like structures for the treatment of persistent hyperuricemia
Biofunctional coacervate-based artificial protocells with membrane-like and cytoplasm-like structures for the treatment of persistent hyperuricemia
The uniform liquid phase is separated into two or more immiscible liquid phases with different components dominated by cha...
Biomimetic hybrid nanovesicles improve infected diabetic wound via enhanced targeted delivery
Biomimetic hybrid nanovesicles improve infected diabetic wound via enhanced targeted delivery
The rapidly increased incidence of diabetes worldwide has caused a global health challenge [1,2]. Infected diabetic wounds...
Targeted delivery of herpes simplex virus glycoprotein D to CD169+ macrophages using ganglioside liposomes alleviates herpes simplex keratitis in mice
Targeted delivery of herpes simplex virus glycoprotein D to CD169+ macrophages using ganglioside liposomes alleviates herpes simplex keratitis in mice
Globally, about 4.85 billion people of all ages are infected with herpes simplex virus type 1 (HSV-1) [1]. HSV-1 can infec...
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