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Countries Manufacturing Pharmaceuticals for the US Market: A 10-Year Analysis of Public Data
Countries Manufacturing Pharmaceuticals for the US Market: A 10-Year Analysis of Public Data
Background:Concerns about strategic supplies and quality have increased the scrutiny of the countries where US pharmaceuti...
Olanzapine/Samidorphan: New Drug Approved for Treating Bipolar I Disorder and Schizophrenia
Olanzapine/Samidorphan: New Drug Approved for Treating Bipolar I Disorder and Schizophrenia
ObjectiveTo describe the approval of olanzapine/samidorphan, compare the clinical trial data, and summarize key findings, ...
A Scoping Review Evaluating the Effect of SGLT-2 Inhibitors on Insulin Dose Requirements in Insulin-Dependent Patients With Type 2 Diabetes
A Scoping Review Evaluating the Effect of SGLT-2 Inhibitors on Insulin Dose Requirements in Insulin-Dependent Patients With Type 2 Diabetes
ObjectiveAssess evidence describing the effect of Sodium-Glucose Cotransporter-2 (SGLT2) inhibitors on total daily insulin...
A Retrospective Characterization of Dexmedetomidine-Suspected Fever and Its Consequences in Adult Critically Ill Patients
A Retrospective Characterization of Dexmedetomidine-Suspected Fever and Its Consequences in Adult Critically Ill Patients
Background:Current evidence for dexmedetomidine-suspected fever (DSF) is limited. Lack of recognition may lead to costly o...
Balanced Crystalloid Versus Normal Saline as Resuscitative Fluid in Diabetic Ketoacidosis
Balanced Crystalloid Versus Normal Saline as Resuscitative Fluid in Diabetic Ketoacidosis
Background:Large volume resuscitation with normal saline (NS) may be associated with iatrogenic hyperchloremia and renal i...
Cerebral Venous Sinus Thrombosis in a Young Body Builder Man With Androgen Use
Cerebral Venous Sinus Thrombosis in a Young Body Builder Man With Androgen Use
1. Ameri, A, Bousser, MG. Cerebral venous sinus thrombosis. Neurol Clin. 1992;10:87–111. doi:10.1016/S0733-8619(18)30235-4...
Dark Red Urine in a Patient on Cefiderocol and Ferric Gluconate
Dark Red Urine in a Patient on Cefiderocol and Ferric Gluconate
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Safety and Efficacy of Various Intravenous Insulin Infusion Rates in Patients With and Without Diabetes Presenting With Hypertriglyceridemia
Safety and Efficacy of Various Intravenous Insulin Infusion Rates in Patients With and Without Diabetes Presenting With Hypertriglyceridemia
BackgroundThe use of IV insulin infusions in the acute management of hypertriglyceridemia has only been evaluated in small...
Evidence Needed for Efficacy of Antidepressant Medications Among Patients With Rheumatoid Arthritis
Evidence Needed for Efficacy of Antidepressant Medications Among Patients With Rheumatoid Arthritis
Patients with rheumatoid arthritis (RA) experience pain from inflammation, joint destruction, and neuropathy. Antidepressa...
Finally, an FDA Approval for an Immunization Against COVID-19: Hope on the Horizon
Finally, an FDA Approval for an Immunization Against COVID-19: Hope on the Horizon
ObjectiveCoronavirus disease 2019 (COVID-19) is a respiratory infection known as severe respiratory acute syndrome coronav...
Impact of Defibrotide in the Prevention of Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation
Impact of Defibrotide in the Prevention of Acute Graft-Versus-Host Disease Following Allogeneic Hematopoietic Cell Transplantation
BackgroundDefibrotide is indicated for patients who develop severe sinusoidal obstructive syndrome following allogeneic he...
Finerenone: A Novel Mineralocorticoid Receptor Antagonist for Cardiorenal Protection in CKD and T2DM
Finerenone: A Novel Mineralocorticoid Receptor Antagonist for Cardiorenal Protection in CKD and T2DM
Objective:To describe the pharmacology, clinical and safety evidence, and relevance to clinical practice of finerenone.Dat...
Medication Changes and Diagnosis of New Chronic Illnesses in COVID-19 Intensive Care Unit Survivors
Medication Changes and Diagnosis of New Chronic Illnesses in COVID-19 Intensive Care Unit Survivors
BackgroundCurrently, there is limited literature on the impact of the COVID-19 infection on medications and medical condit...
Evaluation of the Clinical Impact of Thromboprophylaxis in Patients With COVID-19 Following Hospital Discharge
Evaluation of the Clinical Impact of Thromboprophylaxis in Patients With COVID-19 Following Hospital Discharge
Background:Data are limited regarding the incidence of thromboembolism post-hospital discharge among COVID-19 patients. Gu...
Evaluation of Continuous Inhaled Epoprostenol in the Treatment of Acute Respiratory Distress Syndrome, Including Patients With SARS-CoV-2 Infection
Evaluation of Continuous Inhaled Epoprostenol in the Treatment of Acute Respiratory Distress Syndrome, Including Patients With SARS-CoV-2 Infection
BackgroundAcute respiratory distress syndrome (ARDS) management is primarily supportive. Pulmonary vasodilators, such as i...
Site-Specific and Country-of-Origin Labeling for Pharmaceutical Manufacturing
Site-Specific and Country-of-Origin Labeling for Pharmaceutical Manufacturing
There is increasing concern about the quality of pharmaceuticals, especially generics made in Asia. Popular books and news...
Severe Hypocalcemia Due to Skeletal Remineralization After Venetoclax, Bortezomib, and Dexamethasone for Relapsed Multiple Myeloma
Severe Hypocalcemia Due to Skeletal Remineralization After Venetoclax, Bortezomib, and Dexamethasone for Relapsed Multiple Myeloma
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Inclusion of Optimal Guidelines for Pharmacists in UpToDate
Inclusion of Optimal Guidelines for Pharmacists in UpToDate
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Data-Tracking Among Digital Pharmacies
Data-Tracking Among Digital Pharmacies
Alexander R. Zheutlin, MD, MS1, Joshua D. Niforatos, MD, MTS2, Jeremy B. Sussman, MD, MS3, 41Department of Internal Med...
Are Proton Pump Inhibitors More Effective Than Histamine-2-Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients? A Systematic Review and Meta-Analysis of Cohort Studies
Are Proton Pump Inhibitors More Effective Than Histamine-2-Receptor Antagonists for Stress Ulcer Prophylaxis in Critically Ill Patients? A Systematic Review and Meta-Analysis of Cohort Studies
Background:Histamine-2-receptor antagonists (H2RAs) have been largely replaced by proton pump inhibitors (PPIs) for stress...
Adverse Event Profile for Nanoparticle Albumin-Bound Paclitaxel Compared With Solvent-Based Taxanes in Solid-Organ Tumors: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Adverse Event Profile for Nanoparticle Albumin-Bound Paclitaxel Compared With Solvent-Based Taxanes in Solid-Organ Tumors: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Background:Nanoparticle albumin-bound paclitaxel (nab-paclitaxel) is an innovative form of taxane that has superior antitu...
Pepaxto: A New Peptide-Drug Conjugate for Heavily Pretreated Relapsed and Refractory Multiple Myeloma
Pepaxto: A New Peptide-Drug Conjugate for Heavily Pretreated Relapsed and Refractory Multiple Myeloma
Objective:The objective of this article was to review existing data of melflufen (Pepaxto) as an additional treatment opti...
Daratumumab for the Treatment of Multiple Myeloma: A Review of Clinical Applicability and Operational Considerations
Daratumumab for the Treatment of Multiple Myeloma: A Review of Clinical Applicability and Operational Considerations
Objective:To review the available data for the efficacy and safety of daratumumab in the treatment of multiple myeloma (MM...
Development of MDS-Based Predication Model for COPD Severity in Nursing Home Residents
Development of MDS-Based Predication Model for COPD Severity in Nursing Home Residents
BackgroundAssessing chronic obstructive pulmonary disease (COPD) severity is challenging in nursing home (NH) residents du...
Successful Treatment of Concomitant Colitis and Bacteremia Due to Clostridioides Difficile
Successful Treatment of Concomitant Colitis and Bacteremia Due to Clostridioides Difficile
Access to society journal content varies across our titles. If you have access to a journal via a society or association ...
Valproic Acid After Neurosurgery Induces Elevated Risk of Liver Injury: A Prospective Nested Case-Control Study
Valproic Acid After Neurosurgery Induces Elevated Risk of Liver Injury: A Prospective Nested Case-Control Study
BackgroundValproic acid (VPA) has been widely used to prevent epileptic seizures after neurosurgery in China. We have foun...
Intravenous Metoprolol Versus Diltiazem for Rate Control in Atrial Fibrillation
Intravenous Metoprolol Versus Diltiazem for Rate Control in Atrial Fibrillation
BackgroundCurrently, it remains unclear whether β-blockers or nondihydropyridine calcium channel blockers are preferred fo...
Hospital Discharge: An Opportune Time for Antimicrobial Stewardship
Hospital Discharge: An Opportune Time for Antimicrobial Stewardship
Background:Approximately 30% of antimicrobials prescribed in the outpatient setting are unnecessary and up to 50% are inap...
Risk of Hematologic Events With Coadministration of Methotrexate and the Breast Cancer Resistance Protein Inhibitor Febuxostat
Risk of Hematologic Events With Coadministration of Methotrexate and the Breast Cancer Resistance Protein Inhibitor Febuxostat
Background:The breast cancer resistance protein (BCRP) is a key drug transporter found in the liver, kidney, central nervo...
Impact of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RA) on Food Content During Esophagogastroduodenoscopy (EGD)
Impact of Glucagon-Like Peptide-1 Receptor Agonists (GLP-1RA) on Food Content During Esophagogastroduodenoscopy (EGD)
BackgroundGlucagon-like peptide-1 receptor agonists (GLP-1RA) have delayed gastric emptying properties; however, the impac...
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