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Fighting fire with fire: the immune system might be key in our fight against Alzheimer’s disease
Pieter Dujardin is a PhD student at Ghent University and the VIB-UGent Center for Inflammation Research in Ghent, Belgium....
Role of siRNA-based nanocarriers for the treatment of neurodegenerative diseases
Available online 10 January 2022Highlights•The clinical application of siRNA for brain disease therapy remains a significa...
The changing landscape of treatment options in childhood acute lymphoblastic leukaemia
Available online 7 January 2022Highlights•Paediatric acute lymphoblastic leukaemia remains an active research area.•First ...
Dendrimer nanoplatforms for veterinary medicine applications: a concise overview
Available online 6 January 2022Highlights•The sick animal is indeed a threat to man.•Dendrimer nanoplatforms can be used f...
Enhancing access to innovative cancer drugs: cross-sector consensus on a way forward to benefit patients
Available online 22 December 2021Highlights•New discoveries are driving advances in our understanding of cancer and its ev...
Applications of density functional theory in COVID-19 drug modeling
Available online 23 December 2021Highlights•Rapidly evolving COVID-19 pandemic demands the discovery of effective antivira...
Experimental murine models of brainstem gliomas
Available online 23 December 2021Highlights•Brainstem glioma (BG) is a highly aggressive malignancy with poor prognosis.•T...
Organoid and microfluidics-based platforms for drug screening in COVID-19
Catherine Verfaillie is professor in the Faculty of Medicine and head of Stem Cell and Developmental Biology at the Kathol...
Therapeutic potential of targeting regulatory mechanisms of hepatic stellate cell activation in liver fibrosis
Kaveh Baghaei is a principle investigator at the Shahid Beheshti Medical University-Research Institute of Gastroenterology...
Current clinical trials for epigenetic targets and therapeutic inhibitors for pancreatic cancer therapy
Available online 21 December 2021Highlights•Discusses the epigenetic mechanism in pancreatic cancer (PC).•Explores the met...
Bigels as drug delivery systems: from their components to their applications
María Dolores Veiga was awarded a PhD in pharmacy by the Complutense University of Madrid, where she is currently a profes...
Achieving end-to-end success in the clinic: Pfizer’s learnings on R&D productivity
Available online 15 December 2021Highlights•Pfizer achieved an industry leading end-to-end clinical success rate of 21%•Si...
A molecular perspective for the use of type IV tyrosine kinase inhibitors as anticancer therapeutics
Rudradip Das received his B Pharm degree in pharmaceutical technology from West-Bengal University of Technology, Kolkata, ...
Unlocking the Wnt pathway: therapeutic potential of selective targeting FZD7 in cancer
Yonika Larasati obtained a Bachelor of Pharmacy degree from Universitas Gadjah Mada, Indonesia, and a Master of Biological...
Regulatory oversight on the use of experimental therapies during a pandemic: the case of early access to convalescent plasma therapy in three LMICs
Available online 11 December 2021Highlights•Plasma therapy continues to be an option against COVID-19 especially in LMICs....
Multicompartment systems: a putative carrier for combined drug delivery and targeting
Available online 11 December 2021Highlights•Multicompartment drug delivery system.•Targeted carrier system for combination...
Electron diffraction: accelerating drug development
Available online 11 December 2021Highlights•electron diffraction allows for fully characterising nanocrystals.•easy, fast ...
Chemokines and chemokine receptors in inflammatory bowel disease: recent findings and future perspectives
Available online 9 December 2021Highlights•1. Chemokines participate in leukocyte recruitment among other biological funct...
The overlooked vital sign: the importance of measuring sleep in drug development studies
Available online 9 December 2021Highlights•Sleep is a key covariable that potentially impacts the success of drug developm...
The Hedgehog pathway and its inhibitors: emerging therapeutic approaches for basal cell carcinoma
Available online 9 December 2021Highlights•Hedgehog pathway inhibitors are the potential therapeutic approach for the trea...
Molecular interactions at the colchicine binding site in tubulin: an X-ray crystallography perspective
Jiaxing Wang obtained his BS and MS degrees from Peking University Health Science Center (Beijing, China) before joining D...
How much do the public sector and the private sector contribute to biopharmaceutical R&D?
Prof. Steven Simoens is a senior full professor of health economics at KU Leuven. Steven carries out cost(-of-illness) ana...
Molecular modeling in cardiovascular pharmacology: current state of the art and perspectives
Jennifer Lagoutte-Renosi was awarded a PhD in pharmacology in 2017. She is currently a pharmacologist in the University Ho...
Focal adhesion kinase inhibitors in the treatment of solid tumors: preclinical and clinical evidence
Available online 29 November 2021Highlights•Focal adhesion kinase (FAK) is a cytoplasmic protein kinase that is implicated...
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Metagenomic sequencing-driven multidisciplinary approaches to shed light on the untapped microbial natural products
Available online 11 November 2021Highlights•Metagenomics can tap the untapped biosynthetic potential of uncultivable micro...
Targeting T-type channels in cancer: what is on and what is off?
Anna Visa is a postdoctoral researcher at the Biomedical Research Institute of Lleida (IRBLleida). She graduated in biomed...
ImmunoPET imaging of hematological malignancies: from preclinical promise to clinical reality
Available online 24 November 2021Highlights•1. Immuno-positron emission tomography (immunoPET) is a paradigm-shifting imag...
Enhancing preclinical drug discovery with artificial intelligence
Vijayan Ramaswamy Vijayan Ramaswamy (R.S.K Vijayan) is a research scientist at the Institute for Applied Cancer Science, U...
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