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Author Correction: Artificial intelligence guided screening for cardiomyopathies in an obstetric population: a pragmatic randomized clinical trial
Department of Cardiovascular Medicine, Mayo Clinic, Jacksonville, FL, USADemilade A. Adedinsewo, Andrea Carolina Morales-L...
Safe AI-enabled digital health technologies need built-in open feedback
Safe AI-enabled digital health technologies need built-in open feedback
Transparent and mandatory feedback-collection mechanisms should be integrated into AI-enabled digital health technology in...
Author Correction: Sustained aviremia despite anti-retroviral therapy non-adherence in male children after in utero HIV transmission
These authors contributed equally: Nomonde Bengu, Gabriela Cromhout, Emily Adland.Queen Nandi Regional Hospital, Empangeni...
Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS study
Daratumumab plus bortezomib, lenalidomide and dexamethasone for transplant-ineligible or transplant-deferred newly diagnosed multiple myeloma: the randomized phase 3 CEPHEUS study
Frontline daratumumab-based triplet and quadruplet standard-of-care regimens have demonstrated improved survival outcomes ...
First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy
First-in-human study of epidural spinal cord stimulation in individuals with spinal muscular atrophy
Spinal muscular atrophy (SMA) is an inherited neurodegenerative disease causing motoneuron dysfunction, muscle weakness, f...
GPT-4 assistance for improvement of physician performance on patient care tasks: a randomized controlled trial
GPT-4 assistance for improvement of physician performance on patient care tasks: a randomized controlled trial
While large language models (LLMs) have shown promise in diagnostic reasoning, their impact on management reasoning, which...
New neurons are born in the adult human brain
New neurons are born in the adult human brain
Rusty Gage describes how evidence for neurogenesis in the adult human hippocampus shaped our understanding of learning, me...
The MI-CLAIM-GEN checklist for generative artificial intelligence in health
The MI-CLAIM-GEN checklist for generative artificial intelligence in health
The MI-CLAIM checklist has been revised to take account of new capabilities of large language models and other generative ...
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
Tislelizumab plus zanubrutinib for Richter transformation: the phase 2 RT1 trial
In patients with chronic lymphocytic leukemia, Richter transformation (RT) reflects the development of an aggressive lymph...
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Mosunetuzumab with polatuzumab vedotin in relapsed or refractory aggressive large B cell lymphoma: a phase 1b/2 trial
Relapsed/refractory aggressive large B cell lymphoma (LBCL) remains an area of unmet need. Here we report the primary anal...
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Injury-specific signals elicit plasticity in glial cells from patients with brain injury
Glial cells influence brain function and disease progression. This study identifies signals that elicit hemorrhage-specifi...
Representative and equitable participant sampling in health research
Representative and equitable participant sampling in health research
Research participants often do not represent the target population for treatment. Systematic exclusion of particular group...
A toolkit for capturing a representative and equitable sample in health research
A toolkit for capturing a representative and equitable sample in health research
Research participants often do not represent the general population. Systematic exclusion of particular groups from resear...
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
Injury-specific factors in the cerebrospinal fluid regulate astrocyte plasticity in the human brain
The glial environment influences neurological disease progression, yet much of our knowledge still relies on preclinical a...
Meningioma risk stratification with a targeted gene-expression biomarker
Meningioma risk stratification with a targeted gene-expression biomarker
A validated biomarker risk score based on the expression of 34 genes improves risk stratification of patients with meningi...
11 clinical trials that will shape medicine in 2024
11 clinical trials that will shape medicine in 2024
Nature Medicine asks leading researchers to name their top clinical trial for 2024, from base editing and a vaccine agains...
Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping
Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USASylvan C. Baca, Ji-Heui Seo, Matthew P. David...
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
First-line talazoparib with enzalutamide in HRR-deficient metastatic castration-resistant prostate cancer: the phase 3 TALAPRO-2 trial
Preclinical evidence has suggested an interplay between the androgen receptor, which largely drives the growth of prostate...
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
Divarasib plus cetuximab in KRAS G12C-positive colorectal cancer: a phase 1b trial
KRAS G12C mutation is prevalent in ~4% of colorectal cancer (CRC) and is associated with poor prognosis. Divarasib, a KRAS...
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Durability of single-dose HPV vaccination in young Kenyan women: randomized controlled trial 3-year results
Cervical cancer burden is high where prophylactic vaccination and screening coverage are low. We demonstrated in a multice...
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study
Converging evidence indicates that impairments in executive function and information-processing speed limit quality of lif...
Monitoring medical AI device adoption
Monitoring medical AI device adoption
The adoption of medical AI devices in clinical practice is still in its infancy, with uneven usage across procedures and l...
CT scans in young people and risk of hematological malignancies
CT scans in young people and risk of hematological malignancies
A study of nearly one million people who underwent a CT scan before 22 years of age finds that the radiation from CT scans...
Machine learning improves prediction of clinical outcomes for invasive breast cancers
Machine learning improves prediction of clinical outcomes for invasive breast cancers
A prognostic model for invasive breast cancer that is based on interpretable measurements of epithelial, stromal, and immu...
Six ways large language models are changing healthcare
Six ways large language models are changing healthcare
Nature Medicine asks six leading AI researchers to explain how LLM-powered chatbots are having an impact on health, from v...
Semaglutide offers new route to cardiovascular risk reduction
Semaglutide offers new route to cardiovascular risk reduction
In people with cardiovascular disease (without diabetes) and overweight or obesity, the GLP-1 receptor agonist semaglutide...
Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Author Correction: Inhibition of Notch signaling ameliorates insulin resistance in a FoxO1-dependent manner
Authors and AffiliationsDepartment of Medicine, Columbia University, New York, New York, USAUtpal B. Pajvani & Domenic...
Viral, cellular and immune aspects of non-suppressible HIV-1 viremia
Viral, cellular and immune aspects of non-suppressible HIV-1 viremia
We find that people with non-suppressible human immunodeficiency virus (HIV) viremia despite antiretroviral therapy (ART) ...
Retraction Note: NOX4-dependent fatty acid oxidation promotes NLRP3 inflammasome activation in macrophages
Joan and Sanford I. Weill Department of Medicine, Weill Cornell Medical College and New York-Presbyterian Hospital, New Yo...
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
GLP-1 receptor agonists are promising but unproven treatments for alcohol and substance use disorders
Preclinical and initial human studies suggest that glucagon-like peptide-1 receptor agonists may be promising treatments f...
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