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Revisiting Metchnikoff's work in light of the COVID-19 pandemic
Revisiting Metchnikoff's work in light of the COVID-19 pandemic
Revisiting Metchnikoff's work in light of the COVID-19 pandemic illustrates how much this amazing scientist was a polymath...
Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis
Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis
Macrophage autophagy plays a major role in the control and elimination of invading Mycobacterium tuberculosis. However, th...
Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB
Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-κB
Acute lung injury (ALI) is associated with a high mortality due to inflammatory cell infiltration and lung edema. The deve...
Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways
Chrysosplenol D protects mice against LPS-induced acute lung injury by inhibiting oxidative stress, inflammation, and apoptosis via TLR4-MAPKs/NF-κB signaling pathways
This study investigated the effect and mechanism of chrysosplenol D (CD) on LPS-induced acute lung injury in mice. Histolo...
TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
TLRs in COVID-19: How they drive immunopathology and the rationale for modulation
COVID-19 is both a viral illness and a disease of immunopathology. Proximal events within the innate immune system drive t...
Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert ge...
Circulating innate lymphoid cell subtypes and altered cytokine profiles following an atherogenic high-fat diet
Circulating innate lymphoid cell subtypes and altered cytokine profiles following an atherogenic high-fat diet
Impaired Glc tolerance and hyperinsulinemia are a hallmark of type 2 diabetes (T2D) and are associated with an altered inn...
Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection
Neglected roles of IgG Fc-binding protein secreted from airway mucin-producing cells in protecting against SARS-CoV-2 infection
Both innate immunity and acquired immunity are involved in severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) in...
The TNF-α (–238 G/A) polymorphism could protect against development of severe sepsis
The TNF-α (–238 G/A) polymorphism could protect against development of severe sepsis
Primary responses in sepsis-mediated inflammation are regulated by pro-inflammatory cytokines. Variations in the cytokine ...
Wolf–Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation
Wolf–Hirschhorn syndrome candidate 1 facilitates alveolar macrophage pyroptosis in sepsis-induced acute lung injury through NEK7-mediated NLRP3 inflammasome activation
Sepsis is a complex clinical syndrome with high incidence and mortality. Acute lung injury (ALI) is a common complication ...
Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
Effects of fatty acid nitroalkanes on signal transduction pathways and airway macrophage activation
Fatty acid nitroalkenes are reversibly-reactive electrophiles that are endogenously detectable at nM concentrations and di...
Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1
Long non-coding RNA ZFAS1 alleviates sepsis-induced myocardial injury via target miR-34b-5p/SIRT1
Long non-coding RNA ZFAS1 is down-regulated in sepsis. However, whether ZFAS1 participates in sepsis-induced cardiomyopath...
Does chronic dietary exposure to the mycotoxin deoxynivalenol affect the porcine hepatic transcriptome when an acute-phase response is initiated through first or second-pass LPS challenge of the liver?
Does chronic dietary exposure to the mycotoxin deoxynivalenol affect the porcine hepatic transcriptome when an acute-phase response is initiated through first or second-pass LPS challenge of the liver?
The sensitivity of pigs to deoxynivalenol (DON) might be increased by systemic inflammation (SI), which also has consequen...
Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population
Synergistic effect of genetic polymorphisms in TLR6 and TLR10 genes on the risk of pulmonary tuberculosis in a Moldavian population
Polymorphisms in genes that control immune function and regulation may influence susceptibility to pulmonary tuberculosis ...
Implication of Toll/IL-1 receptor domain containing adapters in Porphyromonas gingivalis-induced inflammation
Implication of Toll/IL-1 receptor domain containing adapters in Porphyromonas gingivalis-induced inflammation
Periodontitis is induced by periodontal dysbiosis characterized by the predominance of anaerobic species. TLRs constitute ...
miR-150 and SRPK1 regulate AKT3 expression to participate in LPS-induced inflammatory response
miR-150 and SRPK1 regulate AKT3 expression to participate in LPS-induced inflammatory response
miR-150 was found to target the 3′-untranslated regions of AKT3, and the AKT pathway was affected by SR protein kinase 1 (...
IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants
IRAK-4 in macrophages contributes to inflammatory osteolysis of wear particles around loosened hip implants
TLRs recognizing PAMPS play a role in local immunity and participate in implant-associated loosening. TLR-mediated signali...
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