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Dynamic three dimensional environment for efficient and large scale generation of smooth muscle cells from hiPSCs
Dynamic three dimensional environment for efficient and large scale generation of smooth muscle cells from hiPSCs
Chronic ischemic limb disease often leads to amputation, which remains a significant clinical problem. Smooth-muscle cells...
Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced-intensity conditioning: a double-blind randomized study and literature review
Co-infusion of mesenchymal stromal cells to prevent GVHD after allogeneic hematopoietic cell transplantation from HLA-mismatched unrelated donors after reduced-intensity conditioning: a double-blind randomized study and literature review
Mesenchymal stromal cells (MSC) have immunomodulatory and hematopoiesis-supporting properties that could potentially benef...
Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations
Amniotic fluid-derived stem cells: potential factories of natural and mimetic strategies for congenital malformations
Mesenchymal stem cells (MSCs) derived from gestational tissues offer a promising avenue for prenatal intervention in conge...
Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model
Trehalose extricates impaired mitochondrial and autophagy dysregulation in patient iPSC-derived macular corneal dystrophy disease model
Patient-derived induced pluripotent stem cell (iPSCs) represents a powerful tool for elucidating the underlying disease me...
Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells
Using magnetic resonance relaxometry to evaluate the safety and quality of induced pluripotent stem cell-derived spinal cord progenitor cells
The emergence of induced pluripotent stem cells (iPSCs) offers a promising approach for replacing damaged neurons and glia...
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model
Neural cell engraftment therapy for sporadic Creutzfeldt-Jakob disease restores neuroelectrophysiological parameters in a cerebral organoid model
Sporadic Creutzfeldt-Jakob disease (sCJD), the most common human prion disease, is a fatal neurodegenerative disease with ...
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
CRX haploinsufficiency compromises photoreceptor precursor translocation and differentiation in human retinal organoids
The CRX-associated autosomal dominant retinopathies suggest a possible pathogenic mechanism of gene haploinsufficiency. Ho...
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Emerging role of mesenchymal stromal cells in gynecologic cancer therapy
Mesenchymal stromal cells (MSCs) show considerable promise in regenerative medicine with superior anti-fibrotic, immunomod...
Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Gene editing and cardiac disease modelling for the interpretation of genetic variants of uncertain significance in congenital heart disease
Genomic sequencing in congenital heart disease (CHD) patients often discovers novel genetic variants, which are classified...
The effect of TLR3 priming conditions on MSC immunosuppressive properties
The effect of TLR3 priming conditions on MSC immunosuppressive properties
Mesenchymal stromal cells (MSCs) have regenerative and immunomodulatory properties, making them suitable for cell therapy....
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
Induced pluripotent stem cells modulate the Wnt pathway in the bleomycin-induced model of idiopathic pulmonary fibrosis
The Wnt signaling pathway has been implicated in the pathogenesis of fibrotic disorders and malignancies. Hence, we aimed ...
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
Deciphering the role of extrachromosomal circular DNA in adipose stem cells from old and young donors
The functional impairment of adipose stem cells (ASCs) during aging limits their clinical transformation. Studies have sho...
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Oxidative stress regulation and related metabolic pathways in epithelial–mesenchymal transition of breast cancer stem cells
Epithelial–mesenchymal transition (EMT) is a cell remodeling process in which epithelial cells undergo a reversible ...
Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
Adipose-derived mesenchymal stem cells cultured in serum-free medium attenuate acute contrast-induced nephropathy by exerting anti-apoptotic effects
Contrast-induced nephropathy (CIN) is a major clinical problem associated with acute kidney injury during hospitalization....
Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Correction: Mesenchymal stem cell-secreted prostaglandin E2 ameliorates acute liver failure via attenuation of cell death and regulation of macrophage polarization
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Application of patient-derived induced pluripotent stem cells and organoids in inherited retinal diseases
Inherited retinal diseases (IRDs) can induce severe sight-threatening retinal degeneration and impose a considerable econo...
Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization
Disclosing the molecular profile of the human amniotic mesenchymal stromal cell secretome by filter-aided sample preparation proteomic characterization
The secretome of mesenchymal stromal cells isolated from the amniotic membrane (hAMSCs) has been extensively studied for i...
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
HIF-1α promotes kidney organoid vascularization and applications in disease modeling
Kidney organoids derived from human pluripotent stem cells (HiPSCs) hold huge applications for drug screening, disease mod...
The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model
The influence of inflammation on the characteristics of adipose-derived mesenchymal stem cells (ADMSCs) and tissue repair capability in a hepatic injury mouse model
Mesenchymal stem cells (MSCs) are adult stem cells with self-renewal and multi-directional differentiation potential and p...
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
Lactate: an alternative pathway for the immunosuppressive properties of mesenchymal stem/stromal cells
The metabolic reprogramming of mesenchymal stem/stromal cells (MSC) favoring glycolysis has recently emerged as a new appr...
The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response
The effects of intraovarian injection of autologous menstrual blood-derived mesenchymal stromal cells on pregnancy outcomes in women with poor ovarian response
Assisted reproduction faces a significant obstacle in the form of poor ovarian response (POR) to controlled ovarian stimul...
Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing
Synergistic effect of chitosan-alginate composite hydrogel enriched with ascorbic acid and alpha-tocopherol under hypoxic conditions on the behavior of mesenchymal stem cells for wound healing
In regenerative medicine, especially skin tissue engineering, the focus is on enhancing the quality of wound healing. Also...
Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury
Extracellular vesicles derived from human ESC–MSCs target macrophage and promote anti-inflammation process, angiogenesis, and functional recovery in ACS-induced severe skeletal muscle injury
Acute compartment syndrome (ACS) is one of the most common complications of musculoskeletal injury, leading to the necrosi...
ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4
ADSC secretome constrains NK cell activity by attenuating IL-2-mediated JAK-STAT and AKT signaling pathway via upregulation of CIS and DUSP4
Mesenchymal stem cells (MSCs) have immunomodulatory properties and therapeutic effects on autoimmune diseases through thei...
Bright ferritin for long-term MR imaging of human embryonic stem cells
Bright ferritin for long-term MR imaging of human embryonic stem cells
A non-invasive imaging technology that can monitor cell viability, retention, distribution, and interaction with host tiss...
Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis
Human mesenchymal stem cells derived from adipose tissue showed a more robust effect than those from the umbilical cord in promoting corneal graft survival by suppressing lymphangiogenesis
Mesenchymal stem cells (MSCs) have shown promising potential in allograft survival. However, few reports have focused on c...
The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway
The pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway
Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylh...
Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
Mechanisms and therapeutic prospects of mesenchymal stem cells-derived exosomes for tendinopathy
Tendinopathy is a debilitating and crippling syndrome resulting from the degeneration of tendon tissue, leading to loss of...
Safety and outcomes analysis: transcatheter implantation of autologous angiogenic cell precursors for the treatment of cardiomyopathy
Safety and outcomes analysis: transcatheter implantation of autologous angiogenic cell precursors for the treatment of cardiomyopathy
Stem cell transplantation is an emerging therapy for severe cardiomyopathy, proffering stem cell recruitment, anti-apoptos...
Bioengineered skin constructs based on mesenchymal stromal cells and acellular dermal matrix exposed to inflammatory microenvironment releasing growth factors involved in skin repair
Bioengineered skin constructs based on mesenchymal stromal cells and acellular dermal matrix exposed to inflammatory microenvironment releasing growth factors involved in skin repair
Skin tissue engineering is a rapidly evolving field of research that effectively combines stem cells and biological scaffo...
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