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CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy
CD47 signaling induces hepatic cell death and microglia activation during hepatic encephalopathy
Acute liver failure results from severe hepatic injury and can lead to neurological dysfunction known as hepatic encephalo...
Value of systemic inflammation markers for the detection of minimal and prediction of overt hepatic encephalopathy after TIPS insertion
Value of systemic inflammation markers for the detection of minimal and prediction of overt hepatic encephalopathy after TIPS insertion
Development of overt hepatic encephalopathy (oHE) is a particularly feared complication when considering treatment with tr...
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats
Effects of ginger root extract on cognitive impairment and the Nrf2/GPX4/SLC7A11 signaling pathway in aluminum-exposed rats
Aluminum exposure has been widely demonstrated to cause cognitive impairment and neuronal damage, which are significant fa...
Macaiba palm pulp (Acrocomia intumescens Drude) improves memory and induces anxiolytic-like behavior in dyslipidemic rats
Macaiba palm pulp (Acrocomia intumescens Drude) improves memory and induces anxiolytic-like behavior in dyslipidemic rats
Macaiba pulp is a source of bioactive compounds. This study aimed to evaluate the effects of macaiba pulp on anxiety behav...
Regulation of the blood-brain barrier function by peripheral cues in health and disease
Regulation of the blood-brain barrier function by peripheral cues in health and disease
The blood-brain barrier (BBB) is formed by microvascular endothelial cells which are ensembled with pericytes, astrocytes,...
Exploring role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis
Exploring role of citrus fruits in comorbid neurodegenerative disorders associated with psoriasis
A neurodegenerative illness is a disorder in which the brain and/or spinal cord’s neurons, or nerve cells, gradually...
Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions
Intricate mechanism of anxiety disorder, recognizing the potential role of gut microbiota and therapeutic interventions
Anxiety is a widespread psychological disorder affecting both humans and animals. It is a typical stress reaction; however...
Therapeutic potential of the extract of giant millipede Telodeinopus Canaliculatus on epileptogenesis and associated anxiety-like behavior
Therapeutic potential of the extract of giant millipede Telodeinopus Canaliculatus on epileptogenesis and associated anxiety-like behavior
The secretions of Telodeinopus canaliculatus, a giant millipede, are used in traditional medicine to treat epileptic seizu...
Assessment of blood-brain barrier injury in hypertensive CSVD by 11.7TMR T1mapping and microvascular pathologic changes
Assessment of blood-brain barrier injury in hypertensive CSVD by 11.7TMR T1mapping and microvascular pathologic changes
We used spontaneously hypertensive rats (SHR) as a hypertensive cerebral small vessel disease (CSVD) model to quantify blo...
Energy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis
Energy restriction inhibits β-catenin ubiquitination to improve ischemic stroke injury via USP18/SKP2 axis
Ischemic stroke (IS) remains a global health issue because of its great disability and mortality. Energy restriction (ER) ...
Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review
Ketogenic diet as a therapeutic approach in autism spectrum disorder: a narrative review
The ketogenic diet (KD) originated in the 1920s. It is a dietary model that is low in carbohydrates, adequate in protein, ...
Pyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments
Pyridoxine supplementation before puberty ameliorates MAM-induced cognitive and sensorimotor gating impairments
Schizophrenia is a kind of neurodevelopmental mental disorder in which patients begin to experience changes early in their...
Insights into risk factors and outcomes of post-stroke seizures in Saudi Arabia: a multicenter analysis
Insights into risk factors and outcomes of post-stroke seizures in Saudi Arabia: a multicenter analysis
Post-stroke seizures present a global challenge, yet its frequency and factors associated with its incidence are poorly do...
Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment
Emerging role of Nrf2 in Parkinson’s disease therapy: a critical reassessment
Parkinson’s disease (PD) is the neurodegenerative disorder characterized by the progressive degeneration of nigrostr...
Tribuli Fructus alleviates 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease by suppressing neuroinflammation via JNK signaling
Tribuli Fructus alleviates 1-methyl-4-phenyl 1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease by suppressing neuroinflammation via JNK signaling
Parkinson’s disease (PD) is a neurodegenerative disease characterized by the loss of dopaminergic neurons. In partic...
HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer’s-associated markers
HMG-CoA reductase inhibitor simvastatin ameliorates trimethyltin neurotoxicity and cognitive impairment through reversal of Alzheimer’s-associated markers
Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder in elderly. The neurotoxicant trimethyltin (TMT) ...
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats
Increased ROS levels, antioxidant defense disturbances and bioenergetic disruption induced by thiosulfate administration in the brain of neonatal rats
Sulfite oxidase deficiencies, either caused by deficiency of the apoenzyme or the molybdenum cofactor, and ethylmalonic en...
Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats
Lactobacillus fermentum MCC2760 attenuates neurobehavioral alterations induced by oxidized oils in rats
The common practice of reusing deep-fried oil may derange the ability of the brain to counter free radicals and inflammato...
Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Sestrin2 can alleviate endoplasmic reticulum stress to improve traumatic brain injury by activating AMPK/mTORC1 signaling pathway
Traumatic brain injury (TBI), as a serious central nervous system disease, can result in severe neurological dysfunction o...
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Neutrophil extracellular traps in intracerebral hemorrhage: implications for pathogenesis and therapeutic targets
Intracerebral hemorrhage is a common neurological disease, and its pathological mechanism is complex. As the first recruit...
Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats
Neuroprotective effects of ivermectin against transient cerebral ischemia-reperfusion in rats
Stroke is a leading cause of disability and death worldwide. Ivermectin is a broad-spectrum anti-parasitic agent with pote...
Impact of the metabolic syndrome on prevalence and survival in motor neuron disease: a retrospective case series
Impact of the metabolic syndrome on prevalence and survival in motor neuron disease: a retrospective case series
Metabolic dysfunction is an important factor in the pathogenesis of motor neuron disease, but its prevalence and associati...
Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
Meclizine moderates lipopolysaccharide-induced neuroinflammation in mice through the regulation of AKT/ NF-κβ/ERK/JNK signaling pathway
Neuroinflammation is identified as significant inflammatory reactions occurring in the central nervous system. Lipopolysac...
G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats
G-CSF improved the memory and dendritic morphology impairments in the hippocampal CA1 pyramidal neurons after brain ischemia in the male rats
Stroke remains the leading cause of death and disability in the world. A new potential treatment for stroke is the granulo...
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
Abnormal grey matter structural changes in patients with end-stage kidney disease and mild cognitive impairment: correlations with clinical features
End-stage kidney disease and mild cognitive impairment (ESKD-MCI) affect the quality of life and long-term treatment outco...
Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways
Combining network pharmacology and experimental verification to reveal the mechanism of Chaigui granules in the treatment of depression through PI3K/Akt/mTOR signaling pathways
Chaigui granules are a novel manufactured traditional Chinese antidepressant medicine, which is originated from the ancien...
Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach
Targeting inflammatory signaling in obsessive compulsive disorder: a promising approach
Obsessive-compulsive disorder (OCD) is a neuropsychiatric disorder. Approximately, around 2% to 3% percent of the general ...
Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder
Abnormal expression of long non-coding RNAs RMRP, CTC-487M23.5, and DGCR5 in the peripheral blood of patients with Bipolar disorder
Long non-coding RNAs (lncRNAs) have been recently considered as one of the regulatory mechanisms of the nervous system. He...
Systematic review and meta-analysis of the effects of exercise on cognitive impairment and neuroprotective mechanisms in diabetes mellitus animal models
Systematic review and meta-analysis of the effects of exercise on cognitive impairment and neuroprotective mechanisms in diabetes mellitus animal models
This study aims to assess the effects of exercise on cognitive impairment behavioral performance and neuroprotective mecha...
Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia
Andrographolide inhibits the activation of spinal microglia and ameliorates mechanical allodynia
Andrographolide (Andro), a labdane diterpene, possesses anti-inflammatory properties and has been used to treat numerous i...
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