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Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Correction to: Pancreatic T cell protein–tyrosine phosphatase deficiency affects beta cell function in mice
Department of Nutrition, University of California Davis, 3135 Meyer Hall, Davis, CA, 95616, USAYannan Xi, Siming Liu, Ahme...
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
ADGRL1 is a glucose receptor involved in mediating energy and glucose homeostasis
The brain is a major consumer of glucose as an energy source and regulates systemic glucose as well as energy balance. Alt...
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
A first-in-human, open-label Phase 1b and a randomised, double-blind Phase 2a clinical trial in recent-onset type 1 diabetes with AG019 as monotherapy and in combination with teplizumab
We hypothesised that islet beta cell antigen presentation in the gut along with a tolerising cytokine would lead to antige...
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Oral magnesium supplementation does not affect insulin sensitivity in people with insulin-treated type 2 diabetes and a low serum magnesium: a randomised controlled trial
Hypomagnesaemia has been associated with insulin resistance and an increased risk of type 2 diabetes. Whether magnesium su...
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Paediatric diabetes subtypes in a consanguineous population: a single-centre cohort study from Kurdistan, Iraq
Monogenic diabetes is estimated to account for 1–6% of paediatric diabetes cases in primarily non-consanguineous pop...
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Chronic kidney disease in type 1 diabetes: translation of novel type 2 diabetes therapeutics to individuals with type 1 diabetes
Current management of chronic kidney disease (CKD) in type 1 diabetes centres on glycaemic control, renin–angiotensi...
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Correction to: Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, whi...
Using race as a social construct when looking at differences in racial associations between non‑alcoholic fatty liver disease and type 2 diabetes. Reply to Rollin FG, Washington C, Fluker S-A [letter]
Using race as a social construct when looking at differences in racial associations between non‑alcoholic fatty liver disease and type 2 diabetes. Reply to Rollin FG, Washington C, Fluker S-A [letter]
Authors’ relationships and activities The authors declare that there are n...
Sex influences health: reporting on female characteristics should be mandatory in exercise and physical activity-related diabetes research
Sex influences health: reporting on female characteristics should be mandatory in exercise and physical activity-related diabetes research
Augustana Faculty, University of Alberta, Camrose, AB, CanadaJane E. YardleyAlberta Diabetes Institute, University of Albe...
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Novel time-resolved reporter mouse reveals spatial and transcriptional heterogeneity during alpha cell differentiation
Glucagon-expressing pancreatic alpha cells have attracted much attention for their plasticity to transdifferentiate into i...
Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
Female sex is a risk factor for painful diabetic peripheral neuropathy: the EURODIAB prospective diabetes complications study
While the risk factors for diabetic peripheral neuropathy (DPN) are now well recognised, the risk factors for painful DPN ...
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
Correction to: Cell-autonomous programming of rat adipose tissue insulin signalling proteins by maternal nutrition
Effect of maternal low protein diet on the expression of insulin signalling molecules in epididymal WAT of 14-month-old ma...
Multi-omic prediction of incident type 2 diabetes
Multi-omic prediction of incident type 2 diabetes
The identification of people who are at high risk of developing type 2 diabetes is a key part of population-level preventi...
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
The metabolomic signature of weight loss and remission in the Diabetes Remission Clinical Trial (DiRECT)
High-throughput metabolomics technologies in a variety of study designs have demonstrated a consistent metabolomic signatu...
Glycaemia risk index uncovers distinct glycaemic variability patterns associated with remission status in type 1 diabetes
Glycaemia risk index uncovers distinct glycaemic variability patterns associated with remission status in type 1 diabetes
The aim of this work was to define a unique remission status using glycaemia risk index (GRI) and other continuous glucose...
Associations between type 1 diabetes and educational outcomes: an Aotearoa/New Zealand nationwide birth cohort study using the Integrated Data Infrastructure
Associations between type 1 diabetes and educational outcomes: an Aotearoa/New Zealand nationwide birth cohort study using the Integrated Data Infrastructure
Type 1 diabetes is one of the most common chronic diseases of childhood. It is hypothesised that the metabolic and psychos...
The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes
The metabolic potential of inflammatory and insulinaemic dietary patterns and risk of type 2 diabetes
Diets with higher inflammatory and insulinaemic potential have been associated with an increased risk of type 2 diabetes. ...
Apolipoprotein L genes are novel mediators of inflammation in beta cells
Apolipoprotein L genes are novel mediators of inflammation in beta cells
Inflammation induces beta cell dysfunction and demise but underlying molecular mechanisms remain unclear. The apolipoprote...
MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial
MTNR1B genotype and effects of carbohydrate quantity and dietary glycaemic index on glycaemic response to an oral glucose load: the OmniCarb trial
A type 2 diabetes-risk-increasing variant, MTNR1B (melatonin receptor 1B) rs10830963, regulates the circadian function and...
Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas
Pathogenic monoallelic variants in GLIS3 increase type 2 diabetes risk and identify a subgroup of patients sensitive to sulfonylureas
GLIS3 encodes a transcription factor involved in pancreatic beta cell development and function. Rare pathogenic, bi-alleli...
A narrative commentary about interoperability in medical devices and data used in diabetes therapy from an academic EU/UK/US perspective
A narrative commentary about interoperability in medical devices and data used in diabetes therapy from an academic EU/UK/US perspective
People living with diabetes have many medical devices available to assist with disease management. A critical aspect that ...
Identifying the severity of diabetic retinopathy by visual function measures using both traditional statistical methods and interpretable machine learning: a cross-sectional study
Identifying the severity of diabetic retinopathy by visual function measures using both traditional statistical methods and interpretable machine learning: a cross-sectional study
To determine the extent to which diabetic retinopathy severity stage may be classified using machine learning (ML) and com...
Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin therapy
Contribution of intestinal triglyceride-rich lipoproteins to residual atherosclerotic cardiovascular disease risk in individuals with type 2 diabetes on statin therapy
This study explored the hypothesis that significant abnormalities in the metabolism of intestinally derived lipoproteins a...
Association between timing and consistency of physical activity and type 2 diabetes: a cohort study on participants of the UK Biobank
Association between timing and consistency of physical activity and type 2 diabetes: a cohort study on participants of the UK Biobank
We sought to quantify the relationship between morning, afternoon or evening physical activity and consistency (e.g. routi...
Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice
Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice
Insulin resistance is a major pathophysiological defect in type 2 diabetes and obesity. Numerous experimental and clinical...
The metabolic response of human trophoblasts derived from term placentas to metformin
The metabolic response of human trophoblasts derived from term placentas to metformin
Metformin is increasingly used therapeutically during pregnancy worldwide, particularly in the treatment of gestational di...
Structural changes in Schwann cells and nerve fibres in type 1 diabetes: relationship with diabetic polyneuropathy
Structural changes in Schwann cells and nerve fibres in type 1 diabetes: relationship with diabetic polyneuropathy
Our aim was to investigate structural changes of cutaneous Schwann cells (SCs), including nociceptive Schwann cells (nSCs)...
Quantifying beta cell function in the preclinical stages of type 1 diabetes
Quantifying beta cell function in the preclinical stages of type 1 diabetes
Clinically symptomatic type 1 diabetes (stage 3 type 1 diabetes) is preceded by a pre-symptomatic phase, characterised by ...
Continuous glucose monitoring-derived time in range and CV are associated with altered tissue characteristics of the carotid artery wall in people with type 2 diabetes
Continuous glucose monitoring-derived time in range and CV are associated with altered tissue characteristics of the carotid artery wall in people with type 2 diabetes
Previous studies have suggested that glucose variability may accelerate atherosclerosis progression in people with type 2 ...
Improved prediction of long-term kidney outcomes in people with type 2 diabetes by levels of circulating haematopoietic stem/progenitor cells
Improved prediction of long-term kidney outcomes in people with type 2 diabetes by levels of circulating haematopoietic stem/progenitor cells
We examined whether prediction of long-term kidney outcomes in individuals with type 2 diabetes can be improved by measuri...
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