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Lipid Metabolism, Methylation Aberrant, and Osteoporosis: A Multi-omics Study Based on Mendelian Randomization
Lipid Metabolism, Methylation Aberrant, and Osteoporosis: A Multi-omics Study Based on Mendelian Randomization
Observational studies have shown a causal association between dyslipidemia and osteoporosis, but the genetic causation and...
An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling
An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling
Pathogenic variants disrupting the binding between sclerostin (encoded by SOST) and its receptor LRP4 have previously been...
The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization
The Association Between SHBG and Osteoporosis: A NHANES Cross-Sectional Study and A Bidirectional Mendelian Randomization
This study aimed to examine the association between sex hormone-binding globulin (SHBG) and osteoporosis through a cross-s...
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway
Coenzyme Q10 Protects Against Hyperlipidemia-Induced Osteoporosis by Improving Mitochondrial Function via Modulating miR-130b-3p/PGC-1α Pathway
In hyperlipidemia-induced osteoporosis, bone marrow mesenchymal stem cells (BMSCs) differentiate into more adipocytes than...
A Critical Review of Current Worldwide Definitions of Sarcopenia
A Critical Review of Current Worldwide Definitions of Sarcopenia
With the increasing number of elderly individuals worldwide, the prevalence of age-related loss of muscle mass, referred t...
PLS3 Mutations in X-Linked Osteoporosis: Clinical and Genetic Features in Five New Families
PLS3 Mutations in X-Linked Osteoporosis: Clinical and Genetic Features in Five New Families
Childhood-onset osteoporosis is a rare but clinically significant condition. Studies have shown pathogenic variants in mor...
Genetic, Immunological, Dietary, Gut Microbiota, and Environmental Determinants of Osteoporosis in the Course of Celiac Disease: Which Factor Plays the First Violin in This Orchestra?
Genetic, Immunological, Dietary, Gut Microbiota, and Environmental Determinants of Osteoporosis in the Course of Celiac Disease: Which Factor Plays the First Violin in This Orchestra?
Celiac disease (CD) is a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten i...
Nutrition Interventions on Muscle-Related Components of Sarcopenia in Females: A Systematic Review of Randomized Controlled Trials
Nutrition Interventions on Muscle-Related Components of Sarcopenia in Females: A Systematic Review of Randomized Controlled Trials
Sarcopenia is a skeletal muscle disease categorized by low muscle strength, muscle quantity or quality, and physical perfo...
Narrative Review of Effects of Glucagon-Like Peptide-1 Receptor Agonists on Bone Health in People Living with Obesity
Narrative Review of Effects of Glucagon-Like Peptide-1 Receptor Agonists on Bone Health in People Living with Obesity
Glucagon-like peptide-1 Receptor agonists (GLP-1Ras) such as liraglutide and semaglutide have been recently approved as me...
The Relationship Between Scoliosis, Spinal Bone Density, and Truncal Muscle Strength in Familial Dysautonomia Patients
The Relationship Between Scoliosis, Spinal Bone Density, and Truncal Muscle Strength in Familial Dysautonomia Patients
This combined retrospective and prospective study aimed to investigate the relationship between scoliosis, spinal bone min...
Management of Osteoporosis, Fracture and Falls in People with Multiple Sclerosis: Systematic Review of Guidelines
Management of Osteoporosis, Fracture and Falls in People with Multiple Sclerosis: Systematic Review of Guidelines
People with multiple sclerosis (MS) have a higher prevalence of osteoporosis, falls and fractures. Guidelines for MS popul...
Microarchitecture Alternations of Osteochondral Junction in Patients with Osteonecrosis of the Femoral Head
Microarchitecture Alternations of Osteochondral Junction in Patients with Osteonecrosis of the Femoral Head
The study was aimed to investigate microarchitecture of osteochondral junction in patients with osteonecrosis of the femor...
Hereditary Hypophosphatemic Rickets with Hypercalciuria Presenting with Enthesopathy, Renal Cysts, and High Serum c-Terminal FGF23: Single-Center Experience and Systematic Review
Hereditary Hypophosphatemic Rickets with Hypercalciuria Presenting with Enthesopathy, Renal Cysts, and High Serum c-Terminal FGF23: Single-Center Experience and Systematic Review
Hereditary hypophosphatemic rickets with hypercalciuria (HHRH) is a rare disorder of phosphate homeostasis. We describe a ...
Treatment Effect of Zoledronic Acid in Chronic Non-bacterial Osteomyelitis of the Jaw: A Case Series
Treatment Effect of Zoledronic Acid in Chronic Non-bacterial Osteomyelitis of the Jaw: A Case Series
Chronic non-bacterial osteomyelitis (CNO) is an autoinflammatory, osteolytic bone disorder sometimes localized to a unifoc...
Epidemiology of Tumor-Induced Osteomalacia in Germany Based on Real World Data
Epidemiology of Tumor-Induced Osteomalacia in Germany Based on Real World Data
Tumor-induced osteomalacia (TIO) is an ultra-rare disease caused mostly by benign tumors that secrete fibroblast growth fa...
Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study
Intervertebral Disk Degeneration and Bone Mineral Density: A Bidirectional Mendelian Randomization Study
This study aimed to investigate the causal relationship between bone mineral density (BMD) and intervertebral disk degener...
Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes
Identification of Key Osteoporosis Genes Through Comparative Analysis of Men's and Women's Osteoblast Transcriptomes
Osteoporosis disproportionately affects older women, yet gender differences in human osteoblasts remain unexplored. Identi...
Comparison of Motion Grading in 1,000 Patients by First- and Second-Generation HR-pQCT: A Propensity Score Matched Cohort Study
Comparison of Motion Grading in 1,000 Patients by First- and Second-Generation HR-pQCT: A Propensity Score Matched Cohort Study
In-vivo bone microstructure measured by high-resolution peripheral quantitative computed tomography (HR-pQCT) is gaining i...
Pilot Study: Short Term Impact of Radiation Therapy on Bone Mineral Density and Bone Metabolism
Pilot Study: Short Term Impact of Radiation Therapy on Bone Mineral Density and Bone Metabolism
Despite the risk of complications, high dose radiation therapy is increasingly utilized in the management of selected bone...
The Interconnection Between Muscle and Bone: A Common Clinical Management Pathway
The Interconnection Between Muscle and Bone: A Common Clinical Management Pathway
Often observed with aging, the loss of skeletal muscle (sarcopenia) and bone (osteoporosis) mass, strength, and quality, i...
Mitophagy Activation by Urolithin A to Target Muscle Aging
Mitophagy Activation by Urolithin A to Target Muscle Aging
The age-related loss of skeletal muscle function starts from midlife and if left unaddressed can lead to an impaired quali...
Osteo-Immunology and Hip Fractures
Osteo-Immunology and Hip Fractures
Bone loss in the elderly is associated with fractures and thus a clinically relevant ...
Maximizing Access and Minimizing Barriers to Research in Low- and Middle-Income Countries: Open Access and Health Equity
Maximizing Access and Minimizing Barriers to Research in Low- and Middle-Income Countries: Open Access and Health Equity
Access to published research has always been difficult for researchers and clinicians in low- and middle-income countries,...
Cholesteatoma Severely Impacts the Integrity and Bone Material Quality of the Incus
Cholesteatoma Severely Impacts the Integrity and Bone Material Quality of the Incus
Cholesteatoma can lead to progressive destruction of the auditory ossicles along with conductive hearing loss but precise ...
Correction: SLICC-Frailty Index and Its Association with Low Bone Mineral Density and Vertebral Fractures in Women with Systemic Lupus Erythematosus
Correction: SLICC-Frailty Index and Its Association with Low Bone Mineral Density and Vertebral Fractures in Women with Systemic Lupus Erythematosus
The article “SLICC-Frailty Index and Its Association with Low Bone Mineral Density and Vertebral Fractures in Women with S...
Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis
Genetic Variants in WNT16 and PKD2L1 Locus Affect Heel Ultrasound Bone Stiffness: Analyses from the General Population and Patients Evaluated for Osteoporosis
Osteoporosis, a complex chronic disease with increasing prevalence, is characterised by reduced bone mineral density (BMD)...
Bone Microarchitecture and Volumetric Mineral Density Assessed by HR-pQCT in Patients with 21- and 17α-Hydroxylase Deficiency
Bone Microarchitecture and Volumetric Mineral Density Assessed by HR-pQCT in Patients with 21- and 17α-Hydroxylase Deficiency
Due to disturbances in hormones and long-term glucocorticoid replacement therapy (GRT), congenital adrenocortical hyperpla...
Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades
Clinical Features, Incidence and Treatment Outcome in Pregnancy-Associated Osteoporosis: A Single-Centre Experience over Two Decades
Pregnancy-associated osteoporosis (PAO) is a rare syndrome which typically presents with vertebral fractures during pregna...
The Effect of Effervescent and Buffered Alendronate Compared to Conventional Alendronate on Markers of Bone Turnover: A Randomized Non-inferiority Trial
The Effect of Effervescent and Buffered Alendronate Compared to Conventional Alendronate on Markers of Bone Turnover: A Randomized Non-inferiority Trial
Buffered and effervescent alendronate (ALN-EFF) increases gastric pH and is reported to decrease the risk of gastrointesti...
Impact of EASO/ESPEN-Defined Sarcopenic Obesity Following a Technology-Based Weight Loss Intervention
Impact of EASO/ESPEN-Defined Sarcopenic Obesity Following a Technology-Based Weight Loss Intervention
Sarcopenic Obesity is the co-existence of increased adipose tissue (obesity) and decreased muscle mass or strength (sarcop...
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