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Type 1 diabetes mellitus: a brave new world
Type 1 diabetes mellitus: a brave new world
One hundred years after the Nobel prize was bestowed on Banting and McLeod for the ‘discovery’ of insulin, we ...
Highlights from SfE BES 2023
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Advances in incretin-based therapeutics for obesity
The year 2023 brought reports of highly effective glucagon-like peptide 1 (GLP1) mono-agonists or combinations with amylin...
Harnessing the inflammatory processes in endometriosis
The pathophysiology of endometriosis is underpinned by a complex interplay of inflammatory processes that are responsible ...
Endocrinology in the multi-omics era
Endocrinology in the multi-omics era
Over the past decade, technological advances have enabled cost-efficient, high-throughput analysis of different types of o...
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
Metabolic control of puberty: 60 years in the footsteps of Kennedy and Mitra’s seminal work
An individual’s nutritional status has a powerful effect on sexual maturation. Puberty onset is delayed in response ...
Genomic alterations in thyroid cancer: biological and clinical insights
Genomic alterations in thyroid cancer: biological and clinical insights
Tumours can arise from thyroid follicular cells if they acquire driver mutations that constitutively activate the MAPK sig...
GIP regulates body weight via GABAergic neurons
GIP regulates body weight via GABAergic neurons
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β-cells protected from T1DM by early senescence programme
β-cells protected from T1DM by early senescence programme
Pancreatic β-cells undergo high levels of cellular stress in the early stages of type 1 diabetes mellitus (T1DM), includin...
SGLT inhibitors: a serendipitous glycaemic tale
Competing interests S.A. declares no competing interests. I.L. has received gran...
The metabolic mythos of ketones
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How a common NAFLD genetic risk variant affects human metabolism
How a common NAFLD genetic risk variant affects human metabolism
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A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
A new endometrial organoid: synthetically engineered matrix enhances epithelial–stromal interactions
Over the past decade, the focus on modelling the human endometrium and its cyclical transformations has intensified, drive...
Macrophage and T cell networks in adipose tissue
Macrophage and T cell networks in adipose tissue
The signals and structure of the tissues in which leukocytes reside critically mould leukocyte function and development an...
Antivirals in the treatment of new-onset T1DM
Antivirals in the treatment of new-onset T1DM
The pathogenesis of type 1 diabetes mellitus (T1DM) involves genetic and environmental factors. However, the process is co...
Health equity in endocrinology
Health equity is when every person can achieve their full potential for health and wellbeing. In this Viewpoint, global ex...
The ageing thyroid: implications for longevity and patient care
The ageing thyroid: implications for longevity and patient care
Thyroid hormones have vital roles in development, growth and energy metabolism. Within the past two decades, disturbances ...
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Type 2 diabetes mellitus (T2DM) is characterized by tissue-specific insulin resistance and pancreatic β-cell dysfunct...
Author Correction: Diagnosis and management of prolactin-secreting pituitary adenomas: a Pituitary Society international Consensus Statement
ENDOC Center for Endocrine Tumors, Hamburg, GermanyStephan PetersennUniversity of Duisburg-Essen, Essen, GermanyStephan Pe...
Metabolic elasticity — a new trait associated with health?
Metabolic elasticity — a new trait associated with health?
A recent study by Zhou and colleagues proposed that low metabolic elasticity and gene elasticity are involved in the metab...
Immune cell population prevents weight regain
Immune cell population prevents weight regain
Weight regain after weight loss is a common problem that can increase the risk of metabolic disease. A new study in Cell M...
Stem cell-derived islet therapy: is this the end of the beginning?
Stem cell-derived islet therapy: is this the end of the beginning?
The debut of stem cell-derived islets in the clinic for glycaemic control in patients with type 1 diabetes mellitus has ga...
Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy
Diabetes mellitus in breast cancer survivors: metabolic effects of endocrine therapy
Breast cancer is the most common invasive malignancy in the world, with millions of survivors living today. Type 2 diabete...
Brain insulin action in women
Brain insulin action in women
In humans, insulin action in the brain increases peripheral insulin sensitivity; however, the studies demonstrating these ...
Obesity is transferable through the gut microbiota
Since the discovery in the 1600s of microscopic organisms, scientists have investigated the relationship between our healt...
Unveiling the telomere–p53–PGC ageing axis
Telomeres are nucleoprotein structures that comprise repetitive nucleotide sequences bound to specialized proteins at the ...
GWAS gives insights into glucose regulation
GWAS gives insights into glucose regulation
Fasting levels of glucose and susceptibility to type 2 diabetes mellitus (T2DM) are known to have a large genetic componen...
Sex differences in cardiometabolic health
Women and men have different risk profiles for certain health conditions. For instance, differences in body composition be...
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity
Adipose tissue is an endocrine organ and a crucial regulator of energy storage and systemic metabolic homeostasis. Additio...
Long-term effects of untreated leptin deficiency
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