The evolving functions of the vasculature in regulating adipose tissue biology in health and obesity

Wolfrum, C. & Gerhart-Hines, Z. Fueling the fire of adipose thermogenesis. Science 375, 1229–1231 (2022).

Article  CAS  PubMed  Google Scholar 

Chew, N. W. S. et al. The global burden of metabolic disease: data from 2000 to 2019. Cell Metab. 35, 414–428.e3 (2023).

Article  CAS  PubMed  Google Scholar 

Herold, J. & Kalucka, J. Angiogenesis in adipose tissue: the interplay between adipose and endothelial cells. Front. Physiol. 11, 624903 (2020).

Article  PubMed  Google Scholar 

Li, M., Qian, M. & Xu, J. Vascular endothelial regulation of obesity-associated insulin resistance. Front. Cardiovasc. Med. 4, 51 (2017).

Article  PubMed  PubMed Central  Google Scholar 

Kalucka, J. et al. Single-cell transcriptome atlas of murine endothelial cells. Cell 180, 764–779.e20 (2020).

Article  CAS  PubMed  Google Scholar 

Emont, M. P. et al. A single-cell atlas of human and mouse white adipose tissue. Nature 603, 926–933 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Strieder-Barboza, C. et al. Single-nuclei transcriptome of human AT reveals metabolically distinct depot-specific adipose progenitor subpopulations. Preprint at bioRxiv https://doi.org/10.1101/2022.06.29.496888 (2022).

Whytock, K. L. et al. Single cell full-length transcriptome of human subcutaneous adipose tissue reveals unique and heterogeneous cell populations. iScience 25, 104772 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Crewe, C. et al. An endothelial-to-adipocyte extracellular vesicle axis governed by metabolic state. Cell 175, 695–708.e13 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Bondareva, O. & Sheikh, B. N. Vascular homeostasis and inflammation in health and disease-lessons from single cell technologies. Int. J. Mol. Sci. 21, 4688 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Vijay, J. et al. Single-cell analysis of human adipose tissue identifies depot and disease specific cell types. Nat. Metab. 2, 97–109 (2020).

Article  PubMed  Google Scholar 

Bondareva, O. et al. Single-cell profiling of vascular endothelial cells reveals progressive organ-specific vulnerabilities during obesity. Nat. Metab. 4, 1591–1610 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

AlZaim, I., Festa, J. & Kalucka, J. Adipose tissue lymphatic endothelial cells: revisited functions in the modulation of adipose biology. Curr. Opin. Physiol. 34, 100675 (2023).

Article  CAS  Google Scholar 

Corvera, S., Solivan-Rivera, J. & Yang Loureiro, Z. Angiogenesis in adipose tissue and obesity. Angiogenesis 25, 439–453 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Tabula Sapiens, C. et al. The tabula sapiens: a multiple-organ, single-cell transcriptomic atlas of humans. Science 376, eabl4896 (2022).

Article  Google Scholar 

Abumrad, N. A. et al. Endothelial cell receptors in tissue lipid uptake and metabolism. Circ. Res. 128, 433–450 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pi, X., Xie, L. & Patterson, C. Emerging roles of vascular endothelium in metabolic homeostasis. Circ. Res. 123, 477–494 (2018).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ioannidou, A., Fisher, R. M. & Hagberg, C. E. The multifaceted roles of the adipose tissue vasculature. Obes. Rev. 23, e13403 (2022).

Article  PubMed  Google Scholar 

Massier, L. et al. An integrated single cell and spatial transcriptomic map of human white adipose tissue. Nat. Commun. 14, 1438 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Amersfoort, J., Eelen, G. & Carmeliet, P. Immunomodulation by endothelial cells – partnering up with the immune system? Nat. Rev. Immunol. 22, 576–588 (2022).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Haynes, B. A. et al. Endothelial-to-mesenchymal transition in human adipose tissue vasculature alters the particulate secretome and induces endothelial dysfunction. Arterioscler. Thromb. Vasc. Biol. 39, 2168–2191 (2019).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Johnston, E. K. & Abbott, R. D. Adipose tissue paracrine-, autocrine-, and matrix-dependent signaling during the development and progression of obesity. Cells 12, 407 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cano, A. et al. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression. Nat. Cell Biol. 2, 76–83 (2000).

Article  CAS  PubMed  Google Scholar 

Villarejo, A., Cortes-Cabrera, A., Molina-Ortiz, P., Portillo, F. & Cano, A. Differential role of Snail1 and Snail2 zinc fingers in E-cadherin repression and epithelial to mesenchymal transition. J. Biol. Chem. 289, 930–941 (2014).

Article  CAS  PubMed  Google Scholar 

Wilhelm, K. et al. FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature 529, 216–220 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ibrahim, A. et al. Insulin-stimulated adipocytes secrete lactate to promote endothelial fatty acid uptake and transport. J. Cell Sci. 135, jcs258964 (2022).

Article  CAS  PubMed  Google Scholar 

Fan, M. et al. Lactate promotes endothelial-to-mesenchymal transition via Snail1 lactylation after myocardial infarction. Sci. Adv. 9, eadc9465 (2023).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Zhu, X. et al. Acetate controls endothelial-to-mesenchymal transition. Cell Metab. 35, 1163–1178.e10 (2023).

Article  CAS  PubMed  Google Scholar 

Zhang, H. et al. LncRNA MEG3 induces endothelial differentiation of mouse derived adipose-derived stem cells by targeting MiR-145-5p/KLF4. Mol. Biol. Rep. 49, 8495–8505 (2022).

Article  CAS  PubMed  Google Scholar 

Sun, X. et al. MicroRNA-181b improves glucose homeostasis and insulin sensitivity by regulating endothelial function in white adipose tissue. Circ. Res. 118, 810–821 (2016).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Liang, X. X. et al. Phosphorylation of Akt at Thr308 regulates p-eNOS Ser1177 during physiological conditions. FEBS Open Bio 11, 1953–1964 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Becker-Greene, D. et al. MiR-409-3p targets a MAP4K3-ZEB1-PLGF signaling axis and controls brown adipose tissue angiogenesis and insulin resistance. Cell Mol. Life Sci. 78, 7663–7679 (2021).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Tang, X. et al. Suppression of endothelial AGO1 promotes adipose tissue browning and improves metabolic dysfunction. Circulation 142, 365–379 (2020).

Article  CAS  PubMed  PubMed Central  Google Scholar 

Mitić, T. & Caporali, A. Emerging roles of non-coding RNAs in endothelial cell function. Curr. Opin. Physiol. 34, 100672 (2023).

Article  Google Scholar 

Mattick, J. S. et al. Long non-coding RNAs: definitions, functions, challenges and recommendations. Nat. Rev. Mol. Cell Biol. 24, 430–447 (2023).

Article  CAS  PubMed  Google Scholar 

Graupera, M. & Claret, M. Endothelial cells: new players in obesity and related metabolic disorders. Trends Endocrinol. Metab. 29, 781–794 (2018).

Article  CAS  PubMed  Google Scholar 

Vliora, M. et al. The impact of adipokines on vascular networks in adipose tissue. Cytokine Growth Factor Rev. 69, 61–72 (2023).

Article  CAS  PubMed  Google Scholar 

Vaiopoulos, A. G., Marinou, K., Christodoulides, C. & Koutsilieris, M. The role of adiponectin in human vascular physiology. Int. J. Cardiol. 155, 188–193 (2012).

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