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Natural agents as wound-healing promoters
Natural agents as wound-healing promoters
The management of acute and chronic wounds resulting from diverse injuries poses a significant challenge to clinical pract...
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Assessment of antiarthritic potential of Asparagus dumosus using formaldehyde and CFA-induced arthritic models in rats via modulation of oxidative stress biomarkers and mRNA expression of IL-1b, IL-6, RANKL, OPG, TNF-α and COX-2
Medicinal plants play a pivotal role in the prevention of chronic non-communicable diseases including arthritis. Despite t...
Using aspirin to prevent and treat cancer
Using aspirin to prevent and treat cancer
This review will discuss evidence that aspirin possesses anticancer activity. Long-term observational retrospective studie...
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Antinociceptive and antiedema effects produced in rats by Brassica oleracea var. italica sprouts involving sulforaphane
Natural products are recognized as potential analgesics since many of them are part of modern medicine to relieve pain wit...
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Resveratrol protects against Schistosoma mansoni-induced liver fibrosis by targeting the Sirt-1/NF-κB axis
Hepatic schistosomiasis is a prevalent form of chronic liver disease that drastically affects human health. Nevertheless, ...
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Therapeutic potential and possible mechanisms of ginseng for depression associated with COVID-19
Recently, a global outbreak of COVID-19 has rapidly spread to various national regions. As the number of COVID-19 patients...
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Linking NLRP3 inflammasome and pulmonary fibrosis: mechanistic insights and promising therapeutic avenues
Pulmonary fibrosis is a devastating disorder distinguished by redundant inflammation and matrix accumulation in the lung i...
Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
Liensinine reduces acute lung injury brought on by lipopolysaccharide by inhibiting the activation of the NF-κB signaling pathway through modification of the Src/TRAF6/TAK1 axis
ALI is characterized by macrophage-driven inflammation, causing severe lung damage. Currently, there are limited therapeut...
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
L-Carnitine augments probenecid anti-inflammatory effect in monoiodoacetate-induced knee osteoarthritis in rats: involvement of miRNA-373/P2X7/NLRP3/NF-κB milieu
Osteoarthritis (OA) is a degenerative joint disease, whereas the underlying molecular trails involved in its pathogenesis ...
Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug
Synthesis of novel nonsteroidal anti-inflammatory galloyl β-sitosterol-loaded lignin-capped Ag-based drug
Biocompatible anti-inflammatory lignin-capped Ag (LCAg) nanoparticles (NPs) were synthesized for the delivery of galloyl &...
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Ibuprofen inhibits anaplastic thyroid cells in vivo and in vitro by triggering NLRP3-ASC-GSDMD-dependent pyroptosis
Pyroptosis is a novel type of proinflammatory programmed cell death that is associated with inflammation, immunity, and ca...
Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
Synthesis, molecular docking, analgesic, anti-inflammatory, and ulcerogenic evaluation of thiophene-pyrazole candidates as COX, 5-LOX, and TNF-α inhibitors
The thiophene bearing pyrazole derivatives (7a-j) were synthesized and examined for their in vitro cyclooxygenase, 5-lipox...
Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases
Innovative preconditioning strategies for improving the therapeutic efficacy of extracellular vesicles derived from mesenchymal stem cells in gastrointestinal diseases
Gastrointestinal (GI) diseases have become a global health issue and an economic burden due to their wide distribution, la...
Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification
Management of ulcerative colitis by dichloroacetate: Impact on NFATC1/NLRP3/IL1B signaling based on bioinformatics analysis combined with in vivo experimental verification
The inflammatory response in ulcerative colitis (UC) could be relieved by the conventional immunomodulatory agents; 5-amin...
Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer
Plant-based green synthesis of nanoparticles as an effective and safe treatment for gastric ulcer
Gastric ulcer is a chronic disease that affects about 10% of the world’s population. This disease is caused...
Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches
Acetylsalicylic acid (ASA), also known as aspirin, was discovered in 1897 as an acetylated form of salicylate. It has been...
Curcumin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway
Curcumin and PCI-34051 combined treatment ameliorates inflammation and fibrosis by affecting MAP kinase pathway
Bronchoconstriction, along with inflammation and hyperresponsiveness is the characteristic feature associated with asthma,...
Nigella sativa and its chemical constituents: pre-clinical and clinical evidence for their potential anti-SARS-CoV-2 effects
Nigella sativa and its chemical constituents: pre-clinical and clinical evidence for their potential anti-SARS-CoV-2 effects
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused over 500 million reported cases of COVID-19 worldw...
Correction: Cardiovascular effect of inflammation and nonsteroidal anti-inflammatory drugs on renin–angiotensin system in experimental arthritis
Correction: Cardiovascular effect of inflammation and nonsteroidal anti-inflammatory drugs on renin–angiotensin system in experimental arthritis
Representative Westernblot images for various target proteins in heart and kidney. AA adjuvant arthritis, AA Control AA no...
A new acyl derivative of sulfadimethoxine inhibits phagocyte oxidative burst and ameliorates inflammation in a mice model of zymosan-induced generalised inflammation
A new acyl derivative of sulfadimethoxine inhibits phagocyte oxidative burst and ameliorates inflammation in a mice model of zymosan-induced generalised inflammation
Chronic inflammation and oxidative stress play a pivotal role in the pathophysiology of most challenging illnesses, includ...
Effect of nitro-conjugated linoleic acid on the inflammatory response of murine macrophages activated with lipopolysaccharide derived from Prevotella intermedia
Effect of nitro-conjugated linoleic acid on the inflammatory response of murine macrophages activated with lipopolysaccharide derived from Prevotella intermedia
Nitro-conjugated linoleic acid (NO2-CLA) has been observed to manifest salutary signaling responses, including anti-inflam...
Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI–MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model
Comprehensive phytochemical characterization of Persea americana Mill. fruit via UPLC/HR-ESI–MS/MS and anti-arthritic evaluation using adjuvant-induced arthritis model
Persea americana Mill. (avocado fruit) has many health benefits when added to our diet due to various pharmacological acti...
Recent advances in anti-inflammatory active components and action mechanisms of natural medicines
Recent advances in anti-inflammatory active components and action mechanisms of natural medicines
Inflammation is a series of reactions caused by the body’s resistance to external biological stimuli. Inflammation a...
Dietary tannic acid attenuates elastase-induced pulmonary inflammation and emphysema in mice
Dietary tannic acid attenuates elastase-induced pulmonary inflammation and emphysema in mice
Emphysema is one of the major components of chronic obstructive pulmonary disease (COPD), which is characterised by the de...
Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives
Chronic inflammation is a common underlying factor in many major diseases, including heart disease, diabetes, cancer, and ...
Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund’s adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers
Curcuminoids-enriched extract and its cyclodextrin inclusion complexes ameliorates arthritis in complete Freund’s adjuvant-induced arthritic mice via modulation of inflammatory biomarkers and suppression of oxidative stress markers
Curcuma longa extract and its marker curcuminoids have potential use in inflammatory conditions. However, curcuminoids sol...
Topical Nigella sativa L. product: a new candidate for the management of diabetic peripheral neuropathy
Topical Nigella sativa L. product: a new candidate for the management of diabetic peripheral neuropathy
Diabetic neuropathy is one of the most common complications of diabetes. The synthetic drugs available in the market have ...
A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications
A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications
Sulforaphane (SFN) is a type of phytochemical found in many cruciferous vegetables that has been shown to positively benef...
Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy
Pharmacological evaluation of vitamin D in COVID-19 and long COVID-19: recent studies confirm clinical validation and highlight metformin to improve VDR sensitivity and efficacy
Nearly four years after its first appearance, and having gone from pandemic to endemic, the SARS-CoV-2 remains out of cont...
Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes
Anti-inflammatory potential of some eudesmanolide and guaianolide sesquiterpenes
Ten sesquiterpene lactones isolated from Anvillea garcinii (Burm.f.) DC ethanolic extract were assessed for their anti-inf...
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