A mechanistic overview of sulforaphane and its derivatives application in diabetes and its complications

Axelsson AS, Tubbs E, Mecham B, Chacko S, Nenonen HA, Tang Y et al (2017) Sulforaphane reduces hepatic glucose production and improves glucose control in patients with type 2 diabetes. Sci Transl Med 9(394):eaah4477

Article  PubMed  Google Scholar 

Bahadoran Z, Mirmiran P, Hosseinpanah F, Hedayati M, Hosseinpour-Niazi S, Azizi F (2011) Broccoli sprouts reduce oxidative stress in type 2 diabetes: a randomized double-blind clinical trial. Eur J Clin Nutr 65(8):972–977

Article  CAS  PubMed  Google Scholar 

Bahadoran Z, Mirmiran P, Hosseinpanah F, Rajab A, Asghari G, Azizi F (2012a) Broccoli sprouts powder could improve serum triglyceride and oxidized LDL/LDL-cholesterol ratio in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Diabetes Res Clin Pract 96(3):348–354

Article  CAS  PubMed  Google Scholar 

Bahadoran Z, Tohidi M, Nazeri P, Mehran M, Azizi F, Mirmiran P (2012b) Effect of broccoli sprouts on insulin resistance in type 2 diabetic patients: a randomized double-blind clinical trial. Int J Food Sci Nutr 63(7):767–771

Article  CAS  PubMed  Google Scholar 

Bahadoran Z, Mirmiran P, Azizi F (2013) Potential efficacy of broccoli sprouts as a unique supplement for management of type 2 diabetes and its complications. J Med Food 16(5):375–382

Article  CAS  PubMed  Google Scholar 

Bai Y, Cui W, Xin Y, Miao X, Barati MT, Zhang C et al (2013) Prevention by sulforaphane of diabetic cardiomyopathy is associated with up-regulation of Nrf2 expression and transcription activation. J Mol Cell Cardiol 57:82–95

Article  CAS  PubMed  Google Scholar 

Bai Y, Wang X, Zhao S, Ma C, Cui J, Zheng Y (2015) Sulforaphane protects against cardiovascular disease via Nrf2 activation. Oxid Med Cell Longev 2015:1

Article  Google Scholar 

Baradaran Rahimi V, Rajabian A, Rajabi H, Mohammadi Vosough E, Mirkarimi HR, Hasanpour M et al (2020) The effects of hydro-ethanolic extract of Capparis spinosa (C. spinosa) on lipopolysaccharide (LPS)-induced inflammation and cognitive impairment: evidence from in vivo and in vitro studies. J Ethnopharmacol 256:112706. https://doi.org/10.1016/j.jep.2020.112706

Article  CAS  PubMed  Google Scholar 

Basha SC, Babu KR, Madhu M, Gopinath C (2017) In vitro antidiabetic activity of sulforaphane. Pharmacol Toxicol Biomed Rep 3(2):47

Article  Google Scholar 

Bernuzzi F, Maertens A, Saha S, Troncoso-Rey P, Ludwig T, Hiller K et al (2023) Sulforaphane rewires central metabolism to support antioxidant response and achieve glucose homeostasis. Redox Biol J 67:102878

Article  CAS  Google Scholar 

Betz C, Stracka D, Prescianotto-Baschong C, Frieden M, Demaurex N, Hall MN (2013) mTOR complex 2-Akt signaling at mitochondria-associated endoplasmic reticulum membranes (MAM) regulates mitochondrial physiology. Proc Natl Acad Sci 110(31):12526–12534

Article  CAS  PubMed  PubMed Central  Google Scholar 

Cole JB, Florez JC (2020) Genetics of diabetes mellitus and diabetes complications. Nat Rev Nephrol 16(7):377–390. https://doi.org/10.1038/s41581-020-0278-5

Article  PubMed  PubMed Central  Google Scholar 

Corssac GB, Campos-Carraro C, Hickmann A, da Rosa Araujo AS, Fernandes RO, Belló-Klein AJB et al (2018) Sulforaphane effects on oxidative stress parameters in culture of adult cardiomyocytes. Biomed Pharmcother 104:165–171

Article  CAS  Google Scholar 

Cui W, Bai Y, Miao X, Luo P, Chen Q, Tan Y et al (2012) Prevention of diabetic nephropathy by sulforaphane: possible role of Nrf2 upregulation and activation. Oxid Med Cell Longev 2012:1

Article  Google Scholar 

de Souza CG, Sattler JA, de Assis AM, Rech A, Perry MLS, Souza DO (2012) Metabolic effects of sulforaphane oral treatment in streptozotocin-diabetic rats. J Med Food 15(9):795–801

Article  PubMed  Google Scholar 

Fuentes F, Paredes-Gonzalez X, Kong A-NT (2015) Dietary glucosinolates sulforaphane, phenethyl isothiocyanate, indole-3-carbinol/3, 3′-diindolylmethane: antioxidative stress/inflammation, Nrf2, epigenetics/epigenomics and in vivo cancer chemopreventive efficacy. Curr Pharmacol Rep 1(3):179–196

Article  CAS  PubMed  PubMed Central  Google Scholar 

He F, Ru X, Wen T (2020) NRF2, a transcription factor for stress response and beyond. Int J Mol Sci 21(13):4777

Article  CAS  PubMed  PubMed Central  Google Scholar 

Jiang X, Bai Y, Zhang Z, Xin Y, Cai L (2014) Protection by sulforaphane from type 1 diabetes-induced testicular apoptosis is associated with the up-regulation of Nrf2 expression and function. Toxicol Appl Pharmacol 279(2):198–210

Article  CAS  PubMed  Google Scholar 

Kayama Y, Raaz U, Jagger A, Adam M, Schellinger IN, Sakamoto M et al (2015) Diabetic cardiovascular disease induced by oxidative stress. Int J Mol Sci 16(10):25234–25263

Article  CAS  PubMed  PubMed Central  Google Scholar 

Kensler TW, Chen J-G, Egner PA, Fahey JW, Jacobson LP, Stephenson KK et al (2005) Effects of glucosinolate-rich broccoli sprouts on urinary levels of aflatoxin-DNA adducts and phenanthrene tetraols in a randomized clinical trial in He Zuo township, Qidong, People’s Republic of China. Cancer Epidemiol Biomark Prev 14(11):2605–2613

Article  CAS  Google Scholar 

Khaleel SA, Raslan NA, Alzokaky AA, Ewees MG, Ashour AA, Abdel-Hamied HE et al (2019) Contrast media (meglumine diatrizoate) aggravates renal inflammation, oxidative DNA damage and apoptosis in diabetic rats which is restored by sulforaphane through Nrf2/HO-1 reactivation. Chem Biol Interact 309:108689

Article  CAS  PubMed  Google Scholar 

Klomparens EA, Ding Y (2019) The neuroprotective mechanisms and effects of sulforaphane. Brain Circ 5(2):74

Article  PubMed  PubMed Central  Google Scholar 

Kong L, Wang H, Li C, Cheng H, Cui Y, Liu L et al (2021) Sulforaphane ameliorates diabetes-induced renal fibrosis through epigenetic up-regulation of BMP-7. Diabetes Metab J 45(6):909–920

Article  PubMed  PubMed Central  Google Scholar 

Langston-Cox A, Anderson D, Creek DJ, Palmer K, Wallace EM, Marshall SA (2020) Measuring sulforaphane and its metabolites in human plasma: a high throughput method. Molecules 25(4):829

Article  CAS  PubMed  PubMed Central  Google Scholar 

Lee JH, Sarker MK, Choi H, Shin D, Kim D, Jun H-S (2019) Lysophosphatidic acid receptor 1 inhibitor, AM095, attenuates diabetic nephropathy in mice by downregulation of TLR4/NF-κB signaling and NADPH oxidase. Biochim Biophys Acta Mol Basis Dis 1865(6):1332–1340

Article  CAS  PubMed  Google Scholar 

Li S, Yang H, Chen X (2019) Protective effects of sulforaphane on diabetic retinopathy: activation of the Nrf2 pathway and inhibition of NLRP3 inflammasome formation. Exp Anim 68(2):221–231

Article  CAS  PubMed  PubMed Central  Google Scholar 

Li Z, Guo H, Li J, Ma T, Zhou S, Zhang Z et al (2020) Sulforaphane prevents type 2 diabetes-induced nephropathy via AMPK-mediated activation of lipid metabolic pathways and Nrf2 antioxidative function. Clin Sci 134(18):2469–2487

Article  CAS  Google Scholar 

Lin C-F, Chueh T-H, Chung C-H, Chung S-D, Chang T-C, Chien C-T (2020) Sulforaphane improves voiding function via the preserving mitochondrial function in diabetic rats. J Formos Med Assoc 119(9):1422–1430

Article  CAS  PubMed  Google Scholar 

Liu D, Wang A, Liu J, Alkhalidy H, Zhen W, Moore W (2017) Genistein in combination with sulforaphane for the treatment of type 2 diabetes. FASEB J 31:646.51-646.51

Google Scholar 

Lv J, Bao S, Liu T, Wei L, Wang D, Ye W et al (2020a) Sulforaphane delays diabetes-induced retinal photoreceptor cell degeneration. Cell Tissue Res 382:477–486

Article  CAS  PubMed  Google Scholar 

Maiese K (2015) New insights for oxidative stress and diabetes mellitus. Oxid Med Cell Longev

Miao X, Bai Y, Sun W, Cui W, Xin Y, Wang Y et al (2012) Sulforaphane prevention of diabetes-induced aortic damage was associated with the up-regulation of Nrf2 and its down-stream antioxidants. Nutr Metabol 9(1):1–9

Article  Google Scholar 

Mirmiran P, Bahadoran Z, Hosseinpanah F, Keyzad A, Azizi F (2012) Effects of broccoli sprout with high sulforaphane concentration on inflammatory markers in type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. J Funct Foods 4(4):837–841

Article  CAS  Google Scholar 

Moustafa PE, Abdelkader NF, El Awdan SA, El-Shabrawy OA, Zaki HF (2018) Extracellular matrix remodeling and modulation of inflammation and oxidative stress by sulforaphane in experimental diabetic peripheral neuropathy. Inflammation 41(4):1460–1476

Article  CAS  PubMed  Google Scholar 

Negi G, Kumar A, Sharma S, S. (2011) Nrf2 and NF-κB modulation by sulforaphane counteracts multiple manifestations of diabetic neuropathy in rats and high glucose-induced changes. Curr Neurovasc Res 8(4):294–304

Article  CAS  PubMed  Google Scholar 

Patel B, Mann GE, Chapple SJJ (2018) Concerted redox modulation by sulforaphane alleviates diabetes and cardiometabolic syndrome. Free Rad Biol Med 122:150–160

Article  CAS  PubMed  Google Scholar 

Pereira A, Fernandes R, Crisóstomo J, Seiça RM, Sena CM (2017) The Sulforaphane and pyridoxamine supplementation normalize endothelial dysfunction associated with type 2 diabetes. Sci Rep 7(1):1–13

Article  Google Scholar 

Pu D, Zhao Y, Chen J, Lv A, Zhu S, Luo C et al (2018) Protective effects of sulforaphane on cognitive impairments and AD-like lesions in diabetic mice are associated with the upregulation of Nrf2 transcription activity. Neuroscience 381:35–45

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