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ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
ARRB1 downregulates acetaminophen-induced hepatoxicity through binding to p-eIF2α to inhibit ER stress signaling
Acetaminophen (APAP) stands as the predominant contributor to drug-induced liver injury (DILI), and limited options are av...
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
Deficiency of copper responsive gene stmn4 induces retinal developmental defects
As part of the central nervous system (CNS), the retina senses light and also conducts and processes visual impulses. The ...
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
POU6F1 promotes ferroptosis by increasing lncRNA-CASC2 transcription to regulate SOCS2/SLC7A11 signaling in gastric cancer
This study investigated the effect and mechanism of POU6F1 and lncRNA-CASC2 on ferroptosis of gastric cancer (GC) cells. G...
m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
m6A modification mediates SLC3A2/SLC7A5 translation in 3-methylcholanthrene-induced uroepithelial transformation
3-Methylcholanthracene (3-MC) is one of the most carcinogenic polycyclic aromatic hydrocarbons (PAHs). Long-term exposure ...
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer mortality globally. Lymph node metastasis and immunosuppression are m...
TFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
TFEB and TFE3 cooperate in regulating inorganic arsenic-induced autophagy-lysosome impairment and immuno-dysfunction in primary dendritic cells
Arsenic (As) is a prevalent and hazardous environmental toxicant associated with cancer and various health problems, which...
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
circGRHPR inhibits aberrant epithelial-mesenchymal transformation progression of lung epithelial cells associated with idiopathic pulmonary fibrosis
Air pollution has greatly increased the risk of idiopathic pulmonary fibrosis (IPF). Circular RNAs (circRNAs) have been fo...
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
METTL3 regulates TFRC ubiquitination and ferroptosis through stabilizing NEDD4L mRNA to impact stroke
Stroke is a major medical problem, and novel therapeutic targets are urgently needed. This study investigates the protecti...
Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1
Circular RNAs (circRNAs) have been documented to play crucial roles in the biology of various cancers. However, their inve...
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway
CD36 inhibition reduces non-small-cell lung cancer development through AKT-mTOR pathway
Lung cancer is the most common cause of cancer-related deaths worldwide and is caused by multiple factors, including high-...
Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation
Deciphering the heterogeneity of neutrophil cells within circulation and the lung cancer microenvironment pre- and post-operation
Neutrophils play a crucial role in the immune system within tumor microenvironment. At present, numerous studies have expl...
Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
Repositioning baloxavir marboxil as VISTA agonist that ameliorates experimental asthma
V-type immunoglobulin domain–containing suppressor of T-cell activation (VISTA), a novel negative checkpoint regulat...
Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension
Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension
Nuclear protein 1 (Nupr1) is a multifunctional stress-induced protein involved in the regulation of tumorigenesis, apoptos...
Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism
Fetal growth restriction exhibits various mTOR signaling in different regions of mouse placentas with altered lipid metabolism
Fetal growth restriction (FGR) is a common complication of pregnancy and can have significant impact on obstetric and neon...
SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway
SUMOylation of RALY promotes vasculogenic mimicry in glioma cells via the FOXD1/DKK1 pathway
Human malignant gliomas are the most common and aggressive primary malignant tumors of the human central nervous system. V...
Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity
Recent advances in pluripotent stem cell-derived cardiac organoids and heart-on-chip applications for studying anti-cancer drug-induced cardiotoxicity
Cardiovascular disease (CVD) caused by anti-cancer drug-induced cardiotoxicity is now the second leading cause of mortalit...
Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial–mesenchymal transition via PFN2 delivery
Urinary extracellular vesicles prevent di-(2-ethylhexyl) phthalate-induced hypospadias by facilitating epithelial–mesenchymal transition via PFN2 delivery
Urinary extracellular vesicles (EVs) have gained increasing interest in recent years as a potential source of noninvasive ...
Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer
Tumor cell-derived exosomes mediating hsa_circ_0001739/lncRNA AC159540.1 facilitate liver metastasis in colorectal cancer
The current study probed into how tumor cell-derived exosomes (Exos) mediated hsa_circ_0001739/lncRNA AC159540.1 to manipu...
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis
NRF2 is essential for iron-overload stimulated osteoclast differentiation through regulation of redox and iron homeostasis
Iron overload enhances osteoclastic bone resorption and induces osteoporosis. Excess iron is highly toxic. The modulation ...
GPC3-IL7-CCL19-CAR-T primes immune microenvironment reconstitution for hepatocellular carcinoma therapy
GPC3-IL7-CCL19-CAR-T primes immune microenvironment reconstitution for hepatocellular carcinoma therapy
Chimeric antigen receptor (CAR)-T-cell therapy is a revolutionary treatment that has become a mainstay of advanced cancer ...
circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression
circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression
Investigation on a competitive endogenous RNA (ceRNA) network attracted lots of attention due its function in cancer regul...
Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response
Andrographolide attenuated MCT-induced HSOS via regulating NRF2-initiated mitochondrial biogenesis and antioxidant response
Hepatic sinusoidal obstruction syndrome (HSOS) is a death-dealing liver disease with a fatality rate of up to 67%. In the ...
Single-cell RNA sequencing reveals differences between force application and bearing in ankle cartilage
Single-cell RNA sequencing reveals differences between force application and bearing in ankle cartilage
Chondrocytes are the major functional elements of articular cartilage. Force has been demonstrated to influence the struct...
Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway
Imatinib and M351-0056 enhance the function of VISTA and ameliorate the development of SLE via IFN-I and noncanonical NF-κB pathway
V-domain immunoglobulin suppressor of T-cell activation (VISTA), an important negative checkpoint protein, participates in...
Targeting autophagy with SAR405 alleviates doxorubicin-induced cardiotoxicity
Targeting autophagy with SAR405 alleviates doxorubicin-induced cardiotoxicity
Anthracycline antitumor agents, such as doxorubicin (DOX), are effective in the treatment of solid tumors and hematologica...
Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer
Targeting the crosstalk of epigenetic modifications and immune evasion in nasopharyngeal cancer
Nasopharyngeal carcinoma (NPC) is a distinct type of head and neck cancer that is highly associated with Epstein-Barr viru...
LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p
LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes via sponging miR-1934-3p
Metabolic dysfunction associated with fatty liver disease (MAFLD), always accompanied by disturbance of glucose and lipid ...
Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis
Loss of Dact2 alleviates cisplatin-induced nephrotoxicity through regulation of the Igfl-MAPK pathway axis
Wnt signaling is a principal pathway regulating the essential activities of cell proliferation. Here, we investigated the ...
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis
GALNT2, an O-glycosylating enzyme, is a critical regulator of radioresistance of non-small cell lung cancer: evidence from an integrated multi-omics analysis
Radioresistance is the primary reason for radiotherapy failure in non-small cell lung cancer (NSCLC) patients. Glycosylati...
Correction to: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway
Correction to: Epigenetic regulation of LINC01270 in breast cancer progression by mediating LAMA2 promoter methylation and MAPK signaling pathway
Department of Thyroid and Breast Surgery, Shenzhen Baoan Women’s and Children’s Hospital, Shenzhen, 518000, Guangdong Prov...
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