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Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Correction: Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Interleukin 1β and interleukin 6 production in human immune cells is stimulated by the antibacterial compound Triclosan
Triclosan (TCS) is an antimicrobial compound widely used in personal hygiene products such as mouthwash and toothpaste; an...
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
Kinetically-derived maximal dose (KMD) indicates lack of human carcinogenicity of ethylbenzene
The kinetically-derived maximal dose (KMD) is defined as the maximal external dose at which kinetics are unchanged relativ...
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful bloom lipopolysaccharides: pro-inflammatory effects on epithelial and immune cells in vitro
Cyanobacterial harmful blooms (CyanoHABs) pose a global ecological problem, and their lipopolysaccharides (LPS) are among ...
The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
The prediction of acute toxicity (LD50) for organophosphorus-based chemical warfare agents (V-series) using toxicology in silico methods
Nerve agents are organophosphate chemical warfare agents that exert their toxic effects by irreversibly inhibiting acetylc...
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Characterization of drug-induced liver injury associated with drug reaction with eosinophilia and systemic symptoms in two prospective DILI registries
Idiosyncratic drug-induced liver injury (DILI) associated with drug reactions with eosinophilia and systemic symptoms (DRE...
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Grouping of esters of 4-hydroxybenzoic acid for hazard assessment
Hazardous properties of a large number of esters of 4-hydroxybenzoic acid (parabens) have been proposed by ECHA to be asse...
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Re-evaluation of the occupational exposure limit for ZnO is warranted. Comments on 'Systemic inflammatory effects of zinc oxide particles: is a re-evaluation of exposure limits needed?' by Christian Monsé et al.
Brand P, Beilmann V, Thomas K et al (2019) The effects of exposure time on systemic inflammation in subjects with exposure...
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Quantification of 108 illicit drugs and metabolites in bile matrix by LC–MS/MS for the toxicological testing of sudden death cases
Sudden death could occur after assumption of illicit drugs for recreational purposes in adults or after intoxication in ch...
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Involvement of mitochondrial dynamics and mitophagy in diabetic endothelial dysfunction and cardiac microvascular injury
Endothelial cells (ECs), found in the innermost layer of blood vessels, are crucial for maintaining the structure and func...
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Comparative metabolism of aflatoxin B1 in mouse, rat and human primary hepatocytes using HPLC–MS/MS
Aflatoxin B1 (AFB1) is a highly hepatotoxic and carcinogenic mycotoxin produced by Aspergillus species. The compo...
Hypermethylation of the ADIRF promoter regulates its expression level and is involved in NNK-induced malignant transformation of lung bronchial epithelial cells
Hypermethylation of the ADIRF promoter regulates its expression level and is involved in NNK-induced malignant transformation of lung bronchial epithelial cells
The carcinogenic mechanism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a well-known tobacco carcinogen, has n...
The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice
The role of inflammation and antioxidant defenses in the cardiotoxicity of doxorubicin in elderly CD-1 male mice
Doxorubicin (DOX) is a potent chemotherapeutic agent used against several cancer types. However, due to its cardiotoxic ad...
Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
Species-differences in the in vitro biotransformation of trifluoroethene (HFO-1123)
1,1,2-Trifluoroethene (HFO-1123) is anticipated for use as a refrigerant with low global warming potential. Inhalation stu...
Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
Analysis of health concerns not addressed by REACH for low tonnage chemicals and opportunities for new approach methodology
In Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH) the criterion for deciding the studies tha...
Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender
Impact of endocrine disruptors on peripheral blood mononuclear cells in vitro: role of gender
Humans can be exposed to endocrine disruptors (EDs) in numerous ways. EDs can interfere with endogenous hormones at differ...
Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Cannabidiol (CBD) is one of the most prevalent and abundant cannabinoids extracted from the plant Cannabis sativa. CBD has...
The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides
The susceptibility of humans to neurodegenerative and neurodevelopmental toxicities caused by organophosphorus pesticides
The toxicology field is concerned with the impact of organophosphorus (OP) compounds on human health. These compounds have...
Role of ErbB and IL-1 signaling pathways in the dermonecrotic lesion induced by Loxosceles sphingomyelinases D
Role of ErbB and IL-1 signaling pathways in the dermonecrotic lesion induced by Loxosceles sphingomyelinases D
Sphingomyelinase D (SMase D), the main toxic component of Loxosceles venom, has a well-documented role on dermonecrotic le...
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice
SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice
Administration of CHK1-targeted anticancer therapies is associated with an increased cumulative risk of cardiac complicati...
Letter to the editor to the article: ‘The presence of carcinogenic compounds in gene‑edited NGOs causes cancer in humans’
Letter to the editor to the article: ‘The presence of carcinogenic compounds in gene‑edited NGOs causes cancer in humans’
In response to I. M. Portant and R. E. Sults and their influential article entitled ‘‘The presence of carcinogenic compoun...
Site-specific genotoxicity of rubiadin: localization and histopathological changes in the kidneys of rats
Site-specific genotoxicity of rubiadin: localization and histopathological changes in the kidneys of rats
Rubiadin (Rub) is a genotoxic component of madder color (MC) that is extracted from the root of Rubia tinctorum L. MC indu...
Toxicokinetics of praseodymium and cerium administered as chloride salts in Sprague–Dawley rats: impacts of the dose and of co-exposure with additional rare earth elements
Toxicokinetics of praseodymium and cerium administered as chloride salts in Sprague–Dawley rats: impacts of the dose and of co-exposure with additional rare earth elements
We conducted a rat exposure study to assess the impacts of dose and co-exposure with other rare earth elements (REEs) on t...
Effects of low concentrations of ozone gas exposure on percutaneous oxygen saturation and inflammatory responses in a mouse model of Dermatophagoides farinae-induced asthma
Effects of low concentrations of ozone gas exposure on percutaneous oxygen saturation and inflammatory responses in a mouse model of Dermatophagoides farinae-induced asthma
Ozone gas is widely used in hospitals as well as homes to control COVID-19 infection owing to its cost-effectiveness. Safe...
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
A dual role for ERK-1/2 in the regulation of plasmin activity and cell migration in metastatic NSCLC-H1299 cells
Occupational and environmental exposure of various toxins or cigarette smoke causes non-small cell lung carcinoma (NSCLC);...
In vitro metabolic profiling of new synthetic cannabinoids, ADB-FUBIATA, AFUBIATA, CH-FUBIATA, and CH-PIATA
In vitro metabolic profiling of new synthetic cannabinoids, ADB-FUBIATA, AFUBIATA, CH-FUBIATA, and CH-PIATA
In the recreational drug market, synthetic cannabinoids with a new acetamide linker structure emerged, most likely to circ...
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects
OCT1-dependent uptake of structurally diverse pyrrolizidine alkaloids in human liver cells is crucial for their genotoxic and cytotoxic effects
Pyrrolizidine alkaloids (PAs) are important plant hepatotoxins, which occur as contaminants in plant-based foods, feeds an...
PFASs–restriction proposal commentary on ECHA’s Annex XV restriction report, proposal for a restriction, March 2023
PFASs–restriction proposal commentary on ECHA’s Annex XV restriction report, proposal for a restriction, March 2023
PFASs are defined as substances that contain at least one fully fluorinated methyl (CF3–) or methylene (–CF2&#...
Correction: Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes
Correction: Heterocyclic amines reduce insulin-induced AKT phosphorylation and induce gluconeogenic gene expression in human hepatocytes
Cite this articleWalls, K.M., Hong, K.U. & Hein, D.W. Correction: Heterocyclic amines reduce insulin-induced AKT phosp...
Confirmation that Hermann Muller was dishonest in his Nobel Prize Lecture
Confirmation that Hermann Muller was dishonest in his Nobel Prize Lecture
In his Nobel Prize Lecture of December 12, 1946, Hermann J. Muller argued that the dose–response for ionizing radiat...
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