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FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
FBH1 deficiency sensitizes cells to WEE1 inhibition by promoting mitotic catastrophe
WEE1 kinase phosphorylates CDK1 and CDK2 to regulate origin firing and mitotic entry. Inhibition of WEE1 has become an att...
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
Targeted nuclear irradiation with a proton microbeam induces oxidative DNA base damage and triggers the recruitment of DNA glycosylases OGG1 and NTH1
DNA is considered a major target for ionizing radiation (IR)-based therapies [1], [2], [3]. Exposure of cells to IR has lo...
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
Potential cGAS-STING pathway functions in DNA damage responses, DNA replication and DNA repair
The major innate immune responder to the DNA of pathogens is the cyclic GMP-AMP (cGAMP) synthase (cGAS) - stimulator of in...
Somatic Mutation Patterns at Ig and Non-Ig Loci
Somatic Mutation Patterns at Ig and Non-Ig Loci
AbbreviationsAadenosine (in RNA) and deoxyadenosine (in DNA)A>>Tmutations in DNA at A exceed mutations at TA-to-Iade...
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
Defects in DNA damage responses in SWI/SNF mutant cells and their impact on immune responses
SWI/SNF complexes are a conserved eukaryotic family of chromatin remodelling activities. In mammalian cells, this family c...
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Interaction of mitoxantrone with abasic sites - DNA strand cleavage and inhibition of apurinic/apyrimidinic endonuclease 1, APE1
Mitoxantrone, 1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione (Fig. 1 A), is an approved...
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system
A non-canonical nucleotide from viral genomes interferes with the oxidative DNA damage repair system
Anna V. Yudkina: Methodology, Formal analysis, Investigation, Resources, Data Curation, Writing - Original Draft, Visualiz...
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites
FAM21 interacts with Ku to promote the localization of WASH to DNA double strand break sites
Genomic integrity is critical to maintain the normal function of organisms. Pathological DNA double strand breaks (DSBs) h...
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation
Renal cell carcinoma (RCC) is a malignancy in the urinary system originating from the renal tubular epithelium with a high...
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
Regulatory apoptotic fragment of PARP1 complements catalytic fragment for PAR and DNA-dependent activity but inhibits DNA-induced catalytic stimulation of PARP2
ADP-ribosyl transferase Diptheria toxin-like 1 (ARTD1), also known as Poly(ADP-ribose) polymerase 1 (PARP1), is a 116 kDa,...
The entanglement of DNA damage and pattern recognition receptor signaling
The entanglement of DNA damage and pattern recognition receptor signaling
Cells are under constant pressure to suppress DNA damage originating from both exogenous and endogenous sources. Cellular ...
The impact of chromatin on double-strand break repair: Imaging tools and discoveries
The impact of chromatin on double-strand break repair: Imaging tools and discoveries
Eukaryotic nuclei are constantly being exposed to factors that break or chemically modify the DNA. Accurate repair of this...
DNA Repair Deficiency and the Immune Microenvironment: A Pathways Perspective
DNA Repair Deficiency and the Immune Microenvironment: A Pathways Perspective
Living organisms are constantly exposed to endogenous and exogenous agents that have the potential to damage cellular DNA....
Regulation of DNA damage-induced HLA class I presentation
Regulation of DNA damage-induced HLA class I presentation
Radiotherapy and DNA damage-based chemotherapy targeting tumor cells are potential partners of immune checkpoint inhibitor...
Telomeres as hotspots for innate immunity and inflammation
Telomeres as hotspots for innate immunity and inflammation
53BP1Tumor Protein P53 Binding Protein 1AGSAicardi-goutières syndromeALTAlternative lengthening of telomeresalt-EJAlternat...
Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
Targeting mitotic regulators in cancer as a strategy to enhance immune recognition
Eukaryotic DNA has evolved to be enclosed within the nucleus to protect the cellular genome from autoinflammatory response...
UvrD-like Helicase Hmi1 Has an ATP Independent Role in Yeast Mitochondrial DNA Maintenance
UvrD-like Helicase Hmi1 Has an ATP Independent Role in Yeast Mitochondrial DNA Maintenance
ATP production via oxidative phosphorylation is arguably the most prominent function of mitochondria. In all eukaryotes, a...
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses
‘From R-lupus to cancer’: Reviewing the role of R-loops in innate immune responses
Cells possess an inherent and evolutionarily conserved ability to detect and respond to the presence of foreign and pathol...
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way
Presenilin-1, mutated in familial Alzheimer’s disease, maintains genome stability via a γ-secretase dependent way
Alzheimer’s disease (AD) is defined neuropathologically by a progressively deposition of amyloid β (Aβ) in parenchyma and ...
Multi-scale cellular imaging of DNA double strand break repair
Multi-scale cellular imaging of DNA double strand break repair
AbbreviationsCNNconvolutional neural networkDNA-PAINTDNA-based Point Accumulation for Imaging in Nanoscale TopographyDSBDN...
Alteration in the chromatin landscape during the DNA damage response: continuous rotation of the gear driving cellular senescence and aging
Alteration in the chromatin landscape during the DNA damage response: continuous rotation of the gear driving cellular senescence and aging
The DNA damage response (DDR) is a crucial biological mechanism for maintaining cellular homeostasis in living organisms. ...
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp–loader interface
The ataxia telangiectasia and Rad3-related (ATR)-dependent DNA damage checkpoint is one of the major DNA damage responses....
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability
Chromatin meets the cytoskeleton: the importance of nuclear actin dynamics and associated motors for genome stability
The actin cytoskeleton is of fundamental importance for numerous cellular processes, including intracellular transport, ce...
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp<img class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/sbnd" />loader interface
The C-terminal tail of Rad17, iVERGE, binds the 9‒1‒1 complex independently of AAA+ ATPase domains to provide another clamp<img class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/sbnd" />loader interface
The ataxia telangiectasia and Rad3-related (ATR)-dependent DNA damage checkpoint is one of the major DNA damage responses....
How RNA impacts DNA repair
How RNA impacts DNA repair
Both prokaryotes and eukaryotes store genetic information in DNA rather than RNA. The primary reason for this preferential...
Live Cell Transcription-coupled Nucleotide Excision Repair Dynamics Revisited
Live Cell Transcription-coupled Nucleotide Excision Repair Dynamics Revisited
Transcription–blocking lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), whi...
CENTROMERE: A TROJAN HORSE FOR GENOME STABILITY
CENTROMERE: A TROJAN HORSE FOR GENOME STABILITY
Available online 7 September 2023, 103569Author links open overlay panel, AbstractCentromeres play a key role in the maint...
TFIIH central activity in nucleotide excision repair to prevent disease
TFIIH central activity in nucleotide excision repair to prevent disease
Keywordsnucleotide excision repairtranscription factor IIH (TFIIH)XPB and XPDXeroderma pigmentosumcockayne syndrometrichot...
The C-terminal tail of Rad17, iVERGE, binds the 9–1<img class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/sbnd" />1 complex independently of AAA+ ATPase domains to provide another clamp<img class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/sbnd" />loader interface
The C-terminal tail of Rad17, iVERGE, binds the 9–1<img class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/sbnd" />1 complex independently of AAA+ ATPase domains to provide another clamp<img class="glyph" src="https://sdfestaticassets-us-east-1.sciencedirectassets.com/shared-assets/16/entities/sbnd" />loader interface
The ataxia telangiectasia and Rad3-related (ATR)-dependent DNA damage checkpoint is one of the major DNA damage responses....
Metazoan Nuclear Pore Complexes in Gene Regulation and Genome Stability
Metazoan Nuclear Pore Complexes in Gene Regulation and Genome Stability
The genetic material of eukaryotic cells is enclosed by the nuclear envelope, a double membrane consisting of an outer nuc...
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