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The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 inflammation and high mortality mechanism trigger
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) lasted from March 2020 to May...
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
A novel missense mutation in the AIRE gene underlying autoimmune polyglandular syndrome type 1
The immune regulator gene AIRE plays an essential role in the establishment of immune tolerance and the prevention of auto...
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Investigating associations between HLA DQA1 ~ DQB1 haplotypes, H. pylori infection, metaplasia, and anti-CagA IgA seropositivity in a Turkish gastritis cohort
Helicobacter pylori was reported as an important cause of gastritis, and gastric ulcers and CagA oncoprotein-producing H. ...
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania
Immunogenetics, sylvatic plague and its vectors: insights from the pathogen reservoir Mastomys natalensis in Tanzania
Yersinia pestis is a historically important vector-borne pathogen causing plague in humans and other mammals. Contemporary...
The KIR2DL1 intermediate upstream element participates in gene activation
The KIR2DL1 intermediate upstream element participates in gene activation
The human KIR genes encode a family of class I MHC receptors that are expressed on subsets of NK cells. The expression of ...
Macroevolution of avian T cell receptor C segments using genomic data
Macroevolution of avian T cell receptor C segments using genomic data
All jawed vertebrates have four T cell receptor (TCR) chains expressed by thymus-derived lymphocytes that play a significa...
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
Comparative genomics of the T cell receptor μ locus in marsupials and monotremes
T cells are a primary component of the vertebrate adaptive immune system. There are three mammalian T cell lineages based ...
Genomic view of the origins of cell-mediated immunity
Genomic view of the origins of cell-mediated immunity
NKp30 is an activating natural killer cell receptor (NKR) with a single-exon variable (VJ)–type immunoglobulin super...
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Correlation between human leukocyte antigen ligands and killer cell immunoglobulin-like receptors in aplastic anemia patients from Shaanxi Han
Regulating natural killer (NK) cell responses in hematological malignancies largely depend on molecular interactions betwe...
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Ancient fish lineages illuminate toll-like receptor diversification in early vertebrate evolution
Since its initial discovery over 50 years ago, understanding the evolution of the vertebrate RAG- mediated adapti...
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
Increased circulating Th17 cell populations in patients with pancreatic ductal adenocarcinoma
T-helper 17 (Th17) cells are a subset of CD4+ helper T cells that produce interleukin 17 (IL-17) and play a crucial role i...
Prof. Dr. Jan Klein (1936-2023)
Prof. Dr. Jan Klein (1936-2023)
Jan Klein was born in 1936 in Stemplovec, a small town in the Czech Republic. Quite f...
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier
Factors regulating the differences in frequency of infiltration of Th17 and Treg of the blood–brain barrier
Controlling CD4+ immune cell infiltration of the brain is a leading aim in designing therapeutic strategies for a range of...
The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The minor chicken class I gene BF1 is deleted between short imperfect direct repeats in the B14 and typical B15 major histocompatibility complex (MHC) haplotypes
The chicken major histocompatibility complex (MHC, also known as the BF-BL region of the B locus) is notably small and sim...
Dysregulated PD-L2 is correlated with disease activity and inflammation in rheumatoid arthritis
Dysregulated PD-L2 is correlated with disease activity and inflammation in rheumatoid arthritis
The programmed death-1 (PD-1) pathway has been shown to deliver an inhibitory signal, and aberrant expression of the PD-1 ...
Correction to: Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Correction to: Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
Prognostic value of the WT-1 gene combined with recurrent cytogenetic genes in acute myeloid leukemia
Prognostic value of the WT-1 gene combined with recurrent cytogenetic genes in acute myeloid leukemia
Wilms tumor gene 1 (WT-1 gene) is overexpressed in most patients with acute myeloid leukemia (AML) and is an indicator for...
Complement component C1q is an immunological rheostat that regulates Fc:Fc $$\gamma$$ R interactions
Complement component C1q is an immunological rheostat that regulates Fc:Fc $$\gamma$$ R interactions
Though binding sites for the complement factor C1q and the canonical fragment crystallizable (Fc) gamma receptors (Fc $$\g...
Immunological assessment of a patient with Omenn syndrome resulting from compound heterozygous mutations in the RAG1 gene
Immunological assessment of a patient with Omenn syndrome resulting from compound heterozygous mutations in the RAG1 gene
The recombination activating gene 1 (RAG1) is essential for V(D)J recombination during T- and B-cell development. In this ...
Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Evaluation of miRNA-16–2-3P, miRNA-618 levels and their diagnostic and prognostic value in the regulation of immune response during SARS Cov-2 infection
Following the announcement of the pandemic of COVID-19 in December 2019, several studies focused on how to early predict t...
Immunogenetics special issue 2023: Immunogenetics of infectious disease
Immunogenetics special issue 2023: Immunogenetics of infectious disease
The evolution of diversity in the face of pathogen challenge forms the very core of i...
Germline-enforced enrichment for charged amino acids in TCR beta chain (TCRβ) complementarity determining region 3 (CDR-B3) alters T cell development, repertoire content, and antigen recognition
Germline-enforced enrichment for charged amino acids in TCR beta chain (TCRβ) complementarity determining region 3 (CDR-B3) alters T cell development, repertoire content, and antigen recognition
T cell receptor beta chain (TCRβ) diversity (Dβ) gene segments are highly conserved across evolution, with trout...
Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine
Impact of high human genetic diversity in Africa on immunogenicity and efficacy of RTS,S/AS01 vaccine
In modern medicine, vaccination is one of the most effective public health strategies to prevent infectious diseases. Indi...
Evolution of immunogenetic components encoding ultralong CDR H3
Evolution of immunogenetic components encoding ultralong CDR H3
The genomes of most vertebrates contain many V, D, and J gene segments within their Ig loci to construct highly variable C...
Characterization and genetic diversity of MHC class II DRB genes in the Arabian camel (Camelus dromedarius)
Characterization and genetic diversity of MHC class II DRB genes in the Arabian camel (Camelus dromedarius)
This study investigated the MHC DRB genes in the Arabian camel (Camelus dromedarius). The results revealed the presence of...
Tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation
Tumor necrosis factor-α induces proliferation and reduces apoptosis of colorectal cancer cells through STAT3 activation
Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory factor that plays an important role in establishing ...
The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides
The + 3010/C single nucleotide polymorphism (rs1710) at the HLA-G 3′ untranslated region is associated with a short transcript exhibiting a deletion of 92 nucleotides
The physiological expression of HLA-G is mainly observed in the placenta, playing an essential role in maternal–feta...
Correction to: The immunogenetics of COVID-19
Correction to: The immunogenetics of COVID-19
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Expression analysis of Carassius auratus-leukocyte-immune-type receptors (CaLITRs) during goldfish kidney macrophage development and in activated kidney leukocyte cultures
Expression analysis of Carassius auratus-leukocyte-immune-type receptors (CaLITRs) during goldfish kidney macrophage development and in activated kidney leukocyte cultures
Carassius auratus leukocyte immune-type receptors (CaLITRs) were recently discovered immunoregulatory receptors in goldfis...
Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct
Correction to: Llama peripheral B-cell populations producing conventional and heavy chain-only IgG subtypes are phenotypically indistinguishable but immunogenetically distinct
Human Health Therapeutics Research Centre, National Research Council Canada, 100 Sussex Drive, Ottawa, ON, K1A 0R6, Canada...
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