Bayly-Jones C, Bubeck D, Dunstone MA (2017) The mystery behind membrane insertion: a review of the complement membrane attack complex. Philos Trans R Soc Lond B Biol Sci 372:20160221

Article  Google Scholar 

Bologna L, Gotti E, Da Roit F, Intermesoli T, Rambaldi A, Introna M, Golay J (2013) Ofatumumab is more efficient than rituximab in lysing B chronic lymphocytic leukemia cells in whole blood and in combination with chemotherapy. J Immunol 190:231–239

Article  CAS  PubMed  Google Scholar 

Botto M, Dell’Agnola C, Bygrave AE, Thompson EM, Cook HT, Petry F, Loos M, Pandolfi PP, Walport MJ (1998) Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies. Nat Genet 19:56–59

Article  CAS  PubMed  Google Scholar 

Botto M, Walport MJ (2002) C1q, Autoimmunity and Apoptosis. Immunobiology 205:395–406

Article  CAS  PubMed  Google Scholar 

Bruhns P (2012) Properties of mouse and human IgG receptors and their contribution to disease models 119:5640–5649

CAS  Google Scholar 

Bruhns P, Iannascoli B, England P, Mancardi DA, Fernandez N, Jorieux S, Daëron M (2009) Specificity and affinity of human Fcγ receptors and their polymorphic variants for human IgG subclasses. Blood 113:3716–3725

Article  CAS  PubMed  Google Scholar 

Calcott MA, Muller-Eberhard HJ (1972) C1q protein of human complement. Biochemistry 11:3443–3450

Article  CAS  PubMed  Google Scholar 

Carroll MC (2004) A protective role for innate immunity in systemic lupus erythematosus. Nat Rev Immunol 4:825–831

Article  CAS  PubMed  Google Scholar 

Clynes R (2005) Immune complexes as therapy for autoimmunity. J Clin Investig 115:25–27

Article  CAS  PubMed  PubMed Central  Google Scholar 

Diebolder CA, Beurskens FJ, de Jong RN, Koning RI, Strumane K, Lindorfer MA, Voorhorst M, Ugurlar D, Rosati S, Heck AJ, van de Winkel JG, Wilson IA, Koster AJ, Taylor RP, Saphire EO, Burton DR, Schuurman J, Gros P, Parren PW (2014) Complement is activated by IgG hexamers assembled at the cell surface. Science 343:1260–1263

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fitzpatrick EA, Wang J, Strome SE (2020) Engineering of Fc Multimers as a Protein Therapy for Autoimmune Disease. Front Immunol 11:496

Article  CAS  PubMed  PubMed Central  Google Scholar 

Flajnik MF, Kasahara M (2001) Comparative Genomics of the MHC: Glimpses into the Evolution of the Adaptive Immune System. Immunity 15:351–362

Article  CAS  PubMed  Google Scholar 

Fraser DA, Bohlson SS, Jasinskiene N, Rawal N, Palmarini G, Ruiz S, Rochford R, Tenner AJ (2006) C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J Leukoc Biol 80:107–116

Article  CAS  PubMed  Google Scholar 

Gaboriaud C, Frachet P, Thielens NM, Arlaud GJ (2012) The Human C1q Globular Domain: Structure and Recognition of Non-Immune Self Ligands. Front Immunol 2

Gadjeva MG, Rouseva MM, Zlatarova AS, Reid KBM, Kishore U, Kojouharova MS (2008) Interaction of Human C1q with IgG and IgM: Revisited. Biochemistry 47:13093–13102

Article  CAS  PubMed  Google Scholar 

Galeotti C, Kaveri SV, Bayry J (2017) IVIG-mediated effector functions in autoimmune and inflammatory diseases. Int Immunol 29:491–498

Article  CAS  PubMed  Google Scholar 

Ghebrehiwet B, Habicht GS, Beck G (1990) Interaction of C1q with its receptor on cultured cell lines induces an anti-proliferative response. Clin Immunol Immunopathol 54:148–160

Article  CAS  PubMed  Google Scholar 

Ghebrehiwet B, Hosszu KK, Valentino A, Peerschke EI (2012) The C1q family of proteins: insights into the emerging non-traditional functions. Front Immunol 3

Golan MD, Burger R, Loos M (1982) Conformational changes in C1q after binding to immune complexes: detection of neoantigens with monoclonal antibodies. J Immunol 129:445–447

Article  CAS  PubMed  Google Scholar 

Heinz HP (1989) Biological functions of C1q expressed by conformational changes. Behring Institute Mitteilungen 20–31

Holers VM (2014) Complement and its receptors: new insights into human disease. Annu Rev Immunol 32:433–459

Article  CAS  PubMed  Google Scholar 

Idusogie EE, Presta LG, Gazzano-Santoro H, Totpal K, Wong PY, Ultsch M, Meng YG, Mulkerrin MG (2000) Mapping of the C1q binding site on rituxan, a chimeric antibody with a human IgG1 Fc. J Immunol 164:4178–4184

Article  CAS  PubMed  Google Scholar 

Jain A, Poonia B, So EC, Vyzasatya R, Burch EE, Olsen HS, Merigeon EY, Block DS, Zhang X, Schulze DH, Hanna NN, Twadell WS, Yfantis HG, Chan SL, Cai L, Strome SE (2013) Tumour antigen targeted monoclonal antibodies incorporating a novel multimerisation domain significantly enhance antibody dependent cellular cytotoxicity against colon cancer. Eur J Cancer 49:3344–3352

Article  CAS  PubMed  Google Scholar 

Kirschfink M, Mollnes TE (2003) Modern complement analysis. Clin Diagn Lab Immunol 10:982–989

CAS  PubMed  PubMed Central  Google Scholar 

Klickstein LB, Barbashov SF, Liu T, Jack RM, Nicholson-Weller A (1997) Complement Receptor Type 1 (CR1, CD35) Is a Receptor for C1q. Immunity 7:345–355

Article  CAS  PubMed  Google Scholar 

Korb LC, Ahearn JM (1997) C1q binds directly and specifically to surface blebs of apoptotic human keratinocytes: complement deficiency and systemic lupus erythematosus revisited. J Immunol 158:4525–4528

Article  CAS  PubMed  Google Scholar 

Lanier LL, Ruitenberg JJ, Phillips JH (1988) Functional and biochemical analysis of CD16 antigen on natural killer cells and granulocytes. J Immunol 141:3478–3485

Article  CAS  PubMed  Google Scholar 

Liang M, Schwickart M, Schneider AK, Vainshtein I, Del Nagro C, Standifer N, Roskos LK (2016) Receptor occupancy assessment by flow cytometry as a pharmacodynamic biomarker in biopharmaceutical development. Cytometry B Clin Cytom 90:117–127

Article  PubMed  Google Scholar 

Lin W, Voskens CJ, Zhang X, Schindler DG, Wood A, Burch E, Wei Y, Chen L, Tian G, Tamada K, Wang LX et al (2008) Fc dependent expression of CD137 on human NK cells: insights into "agonistic" effects of anti-CD137 monoclonal antibodies. Blood blood-2007–2011–122465

Lood C, Gullstrand B, Truedsson L, Olin AI, Alm GV, Ronnblom L, Sturfelt G, Eloranta ML, Bengtsson AA (2009) C1q inhibits immune complex-induced interferon-alpha production in plasmacytoid dendritic cells: a novel link between C1q deficiency and systemic lupus erythematosus pathogenesis. Arthritis Rheum 60:3081–3090

Article  CAS  PubMed  Google Scholar 

Lyu X, Zhao Q, Hui J, Wang T, Lin M, Wang K, Zhang J, Shentu J, Dalby PA, Zhang H, Liu B (2022) The global landscape of approved antibody therapies. Antibody therapeutics 5:233–257

Article  CAS  PubMed  PubMed Central  Google Scholar 

Macedo AC, Isaac L (2016) Systemic Lupus Erythematosus and Deficiencies of Early Components of the Complement Classical Pathway. Front Immunol 7:55

Article  PubMed  PubMed Central  Google Scholar 

Mollnes TE, Garred P, Bergseth G (1988) Effect of time, temperature and anticoagulants on in vitro complement activation: consequences for collection and preservation of samples to be examined for complement activation. Clin Exp Immunol 73:484–488

CAS  PubMed  PubMed Central  Google Scholar 

Meyaard L, Adema GJ, Chang C, Woollatt E, Sutherland GR, Lanier LL, Phillips JH (1997) LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7:283–290

Article  CAS  PubMed  Google Scholar 

Nonaka M, Kimura A (2006) Genomic view of the evolution of the complement system. Immunogenetics 58:701–713

Article  CAS  PubMed  PubMed Central  Google Scholar 

Pickering MC, Walport MJ (2000) Links between complement abnormalities and systemic lupus erythematosus. Rheumatology 39:133–141

Article  CAS  PubMed  Google Scholar 

Pincetic A, Bournazos S, DiLillo DJ, Maamary J, Wang TT, Dahan R, Fiebiger BM, Ravetch JV (2014) Type I and type II Fc receptors regulate innate and adaptive immunity. Nat Immunol 15:707–716

Article  CAS  PubMed  PubMed Central  Google Scholar 

Psychogios N, Hau DD, Peng J, Guo AC, Mandal R, Bouatra S, Sinelnikov I, Krishnamurthy R, Eisner R, Gautam B, Young N, Xia J, Knox C, Dong E, Huang P, Hollander Z, Pedersen TL, Smith SR, Bamforth F, Greiner R, McManus B, Newman JW, Goodfriend T, Wishart DS (2011) The human serum metabolome PloS one 6:e16957

Article  CAS  PubMed  Google Scholar 

Reid KBM (2018) Complement Component C1q: Historical Perspective of a Functionally Versatile, and Structurally Unusual, Serum Protein. Front Immunol 9

Ricklin D, Reis ES, Lambris JD (2016) Complement in disease: a defence system turning offensive. Nat Rev Nephrol 12:383–401

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roumenina LT, Sene D, Radanova M, Blouin J, Halbwachs-Me