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Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq
Profiling the total transcriptome of single nuclei in archived samples with snRandom-seq
In this Tools of the Trade article, Ziye Xu and Yongcheng Wang describe snRandom-seq, a high-throughput, high-sensitivity ...
Diversity and consequences of structural variation in the human genome
Diversity and consequences of structural variation in the human genome
The biomedical community is increasingly invested in capturing all genetic variants across human genomes, interpreting the...
The hidden diversity of tumours
In this Journal Club, Mariana Boroni recalls a 2012 study by Gerlinger et al. that revealed the complex and branched evolu...
Cytoplasmic mRNA decay and quality control machineries in eukaryotes
Cytoplasmic mRNA decay and quality control machineries in eukaryotes
mRNA degradation pathways have key regulatory roles in gene expression. The intrinsic stability of mRNAs in the cytoplasm ...
The early days of transcriptome sequencing and functional genomics
Ayako Suzuki recalls two papers published in the early 2000s by the Functional Annotation of the Mammalian Genome (FANTOM)...
Spatial metabolomics to unravel cellular metabolism
Spatial metabolomics to unravel cellular metabolism
In this Tools of the Trade article, Arafath Najumudeen and Johan Vande Voorde showcase the potential of mass spectrometry ...
Integrating ELSI study teams in paediatric genomic research efforts
Addressing ethical, legal and social implications (ELSI) in genomics requires early integration of specialized teams to en...
Spatial miRNomics: towards the integration of microRNAs in spatial biology
Spatial transcriptomics tools enable the detection and localization of hundreds to thousands of transcripts in biological ...
Decoding human genetic variation using a synthetic paradigm
Aashiq Kachroo highlights a recent paper by van Loggerenberg et al. that demonstrates the experimental power of &...
Divergence and conservation of the meiotic recombination machinery
Divergence and conservation of the meiotic recombination machinery
Sexually reproducing eukaryotes use recombination between homologous chromosomes to promote chromosome segregation during ...
Including diverse populations enhances the discovery of type 2 diabetes loci
Segun Fatumo highlights a paper by Mahajan et al. that uses a multi-ancestry genome-wide association studies approach to u...
Mouse genome rewriting with human DNA for disease modelling
Mouse genome rewriting with human DNA for disease modelling
Zhang et al. describe mSwAP-In, a platform for large-scale, efficient, biallelic and ‘scarless’ genome editing...
Weaponized genomics: potential threats to international and human security
Genetic technologies are revolutionizing human health. In parallel, geopolitical instability has prompted renewed discussi...
Context-specific functions of chromatin remodellers in development and disease
Context-specific functions of chromatin remodellers in development and disease
Chromatin remodellers were once thought to be highly redundant and nonspecific in their actions. However, recent human gen...
SWI/SNF function compensated by another chromatin remodeller
SWI/SNF function compensated by another chromatin remodeller
Martin et al. report that the EP400/TIP60 complex can compensate for function of the SWI/SNF complex to remodel chromatin ...
Translating genomic advances into biodiversity conservation
Translating genomic advances into biodiversity conservation
A key action of the new Global Biodiversity Framework is the maintenance of genetic diversity in all species to safeguard ...
Interrogating epigenetic mechanisms with chemically customized chromatin
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and studying molecular players implicated i...
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs in disease: from mechanisms to therapeutics
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. S...
Controlling organoid gene expression with light
Controlling organoid gene expression with light
Legnini et al. report in Nature Methods their new optogenetic method for controlling gene expression in organoids that can...
De novo genes: from non-genic to genic
Li Zhao recalls a 2006 paper by Levine et al. that, by identifying a handful of de novo genes, outlined a potentially univ...
A genetic atlas of the human blood proteome
A genetic atlas of the human blood proteome
Three papers in Nature report on the largest open-access plasma proteomics dataset to date, a valuable resource for unders...
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Scrambling the genome in cancer: causes and consequences of complex chromosome rearrangements
Complex chromosome rearrangements, known as chromoanagenesis, are widespread in cancer. Based on large-scale DNA sequencin...
WNT regulator controls stripe patterning
WNT regulator controls stripe patterning
Johnson et al. identify a WNT regulator that underlies the development and evolution of distinct colour patterning in the ...
Genomics for monitoring and understanding species responses to global climate change
Genomics for monitoring and understanding species responses to global climate change
All life forms across the globe are experiencing drastic changes in environmental conditions as a result of global climate...
Inborn errors of immunity: an expanding universe of disease and genetic architecture
Inborn errors of immunity: an expanding universe of disease and genetic architecture
Inborn errors of immunity (IEIs) are generally considered to be rare monogenic disorders of the immune system that cause i...
Predicting variant pathogenicity with AlphaMissense
Predicting variant pathogenicity with AlphaMissense
Reporting in Science, a team from Google DeepMind describe AlphaMissense, a tool to predict the pathogenicity of missense ...
Nuclear genome influences mitochondrial DNA
Nuclear genome influences mitochondrial DNA
A paper in Nature finds that nuclear genetic variation can influence heteroplasmy and the human mitochondrial genome.
Author Correction: Transposable elements: McClintock’s legacy revisited
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Sequencing to save the Kākāpō
Sequencing to save the Kākāpō
Guhlin et al. sequenced the genomes of almost the entire extant population of the critically-endangered kākāp...
The evolutionary tale of lactase persistence in humans
Luis Barreiro highlights a 2007 paper by Tishkoff et al. that identified genetic variants associated with lactose persiste...
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