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PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway
PYCR2, induced by c-Myc, promotes the invasiveness and metastasis of breast cancer by activating AKT signalling pathway
BackgroundPyrroline-5-carboxylate reductase 2 (PYCR2) expression is aberrantly upregulated in colon cancer. However, the f...
Corrigendum to “GOLGI: cancer cell fate control” [Int. J. Biochem. Cell Biol. 145 (2022) 106174]
Corrigendum to “GOLGI: cancer cell fate control” [Int. J. Biochem. Cell Biol. 145 (2022) 106174]
Volume 166, January 2024, 106504Author links open overlay panelMarta Martins, Ana Sofia Fernandes, Nuno SaraivaShow morePr...
Hedgehog signalling in CD4+ T helper cell polarisation
Hedgehog signalling in CD4+ T helper cell polarisation
CD4+ T cells are part of the adaptive immune system and can polarise into different T helper (Th) cell subsets to orchestr...
BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease
BNIP3 in hypoxia-induced mitophagy: novel insights and promising target for non-alcoholic fatty liver disease
Non-alcoholic fatty liver disease (NAFLD) remains the most threatening liver disease worldwide. The incidence rate is incr...
THE ROLE OF α7 NICOTINIC ACETYLCHOLINE RECEPTORS IN POST-ACUTE SEQUELAE OF COVID-19
THE ROLE OF α7 NICOTINIC ACETYLCHOLINE RECEPTORS IN POST-ACUTE SEQUELAE OF COVID-19
SARS-Cov-2 infections have claimed nearly 7 million lives worldwide since 2019. While quarantines, non-pharmaceutical mand...
Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1
Molecular and cellular evidence of a direct interaction between the TRAF2 C-terminal domain and ganglioside GM1
AbbreviationsTRAF2TNF receptor-associated factor 2GM1monosialotetrahexosylgangliosideGUVsgiant unilamellar vesiclesPOPC1-p...
The role of zinc finger proteins in the fate determination of mesenchymal stem cells during osteogenic and adipogenic differentiation
The role of zinc finger proteins in the fate determination of mesenchymal stem cells during osteogenic and adipogenic differentiation
MSCs, with the potential for multidirectional differentiation into chondrocytes, osteoblasts, and adipocytes, play a pivot...
Corrigendum to “Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway” [Int. J. Biochem. Cell Biol. 116 (2019) 105620]
Corrigendum to “Diazepam enhances melanogenesis, melanocyte dendricity and melanosome transport via the PBR/cAMP/PKA pathway” [Int. J. Biochem. Cell Biol. 116 (2019) 105620]
Available online 5 December 2023, 106505Author links open overlay panelJinpeng Lv a b c, Ying Fu a, Rongyin Gao d, Jiawen ...
IL-22 Relieves Hepatic Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Apoptosis Based on the Activation of STAT3
IL-22 Relieves Hepatic Ischemia-Reperfusion Injury by Inhibiting Mitochondrial Apoptosis Based on the Activation of STAT3
Hepatic ischemia-reperfusion injury (HIRI) is a major complication of liver surgery, which causes a great threat to the li...
Epigenetic Modification of m6A Methylation: Regulatory Factors, Functions and Mechanism in Inflammatory Bowel Disease
Epigenetic Modification of m6A Methylation: Regulatory Factors, Functions and Mechanism in Inflammatory Bowel Disease
Chronic, recurrent inflammation that primarily affects the intestines but can also impact several organ systems is known a...
ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution
ER-mitochondria contact sites in mitochondrial DNA dynamics, maintenance, and distribution
Proper nucleoid distribution is necessary for the homogenous distribution of mitochondrial proteins, with defects that aff...
Tumor-derived microparticles promoted M2-like macrophages polarization to stimulate osteosarcoma progression
Tumor-derived microparticles promoted M2-like macrophages polarization to stimulate osteosarcoma progression
Osteosarcoma is a malignant bone tumor commonly found in adolescents aged 10-25. The underlying mechanism of osteosarcoma ...
UBC9 stabilizes PFKFB3 to promote aerobic glycolysis and proliferation of glioblastoma cells
UBC9 stabilizes PFKFB3 to promote aerobic glycolysis and proliferation of glioblastoma cells
Posttranslational modifications affect the structures and functions of proteins and play a crucial role in tumorigenesis (...
Tumor protein D52 (isoform 3) induces NF-κB – STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
Tumor protein D52 (isoform 3) induces NF-κB – STAT3 mediated EMT driving neuroendocrine differentiation of prostate cancer cells
Prostate cancer (PCa) is the second leading cause of cancer death in American men after lung cancer, and one in every 41 m...
CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma
CENPL accelerates cell proliferation, cell cycle, apoptosis, and glycolysis via the MEK1/2-ERK1/2 pathway in hepatocellular carcinoma
Centromere protein L (CENPL) is involved in the mitotic process of eukaryotic cells and the development of various types o...
Talin mechanotransduction in disease
Talin mechanotransduction in disease
Talin protein (Talin 1/2) is a mechanosensitive cytoskeleton protein. The unique structure of the Talin plays a vital role...
The bcl6 corepressor mutation regulates the progression and transformation of myelodysplastic syndromes by repressing the autophagy flux
The bcl6 corepressor mutation regulates the progression and transformation of myelodysplastic syndromes by repressing the autophagy flux
Myelodysplastic syndrome (MDS) encompasses a heterogeneous group of bone marrow tumors that have common features including...
Immunosenescence and macrophages: from basics to therapeutics
Immunosenescence and macrophages: from basics to therapeutics
Aging is a gradual process involving the decline of both physiological and psychological aspects in humans. This progressi...
Differential Regulation of Fibronectin Expression and Fibrillogenesis by Autocrine TGF-β1 Signaling in Malignant and Benign Mammary Epithelial Cells
Differential Regulation of Fibronectin Expression and Fibrillogenesis by Autocrine TGF-β1 Signaling in Malignant and Benign Mammary Epithelial Cells
During breast cancer progression, the extracellular matrix (ECM) undergoes extensive remodeling, characterized by disrupti...
DNA mismatch repair deficient cancer – Emerging biomarkers of resistance to immune checkpoint inhibition
DNA mismatch repair deficient cancer – Emerging biomarkers of resistance to immune checkpoint inhibition
The DNA mismatch repair pathway is involved in the identification, excision, and repair of base-base mismatches and indel ...
MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts
MMP13 promotes the osteogenic potential of BMP9 by enhancing Wnt/β-catenin signaling via HIF-1α upregulation in mouse embryonic fibroblasts
As a continuous, rigorous, and dynamic process, bone remodeling plays a critical role in maintaining bone mass and the int...
Wherefore Art Tau? Functional importance of site-specific tau phosphorylation in diverse subcellular domains
Wherefore Art Tau? Functional importance of site-specific tau phosphorylation in diverse subcellular domains
Tau was first identified as a protein encoded by the MAPT gene that promotes stabilization and formation of microtubules, ...
ROCK inhibition reduces the sensitivity of mutant p53 glioblastoma to genotoxic stress through a Rac1-driven ROS production
ROCK inhibition reduces the sensitivity of mutant p53 glioblastoma to genotoxic stress through a Rac1-driven ROS production
Available online 30 September 2023, 106474Author links open overlay panel, ABSTRACTResistance to radio and chemotherapy in...
Role of innate lymphoid cells in cancer metastasis
Role of innate lymphoid cells in cancer metastasis
Metastatic spread of cancer accounts for most cancer-related deaths. Cancer seeding in secondary organs requires reprogram...
CircABPD1 Alleviates Oxidative Lung Injury of Bronchopulmonary Dysplasia Through Regulating miR-330-3p /HIF1α Axis
CircABPD1 Alleviates Oxidative Lung Injury of Bronchopulmonary Dysplasia Through Regulating miR-330-3p /HIF1α Axis
Premature infant lungs, due to immature lung development, are easily damaged when the infants move from a relatively hypox...
Using Single Molecule Imaging to Explore Intracellular Heterogeneity
Using Single Molecule Imaging to Explore Intracellular Heterogeneity
The idea that interactions between individual members drive a collective output is fundamental to biology. It is how fish,...
Circadian Control of Cisplatin-DNA Adduct Repair and Apoptosis in Culture Cells
Circadian Control of Cisplatin-DNA Adduct Repair and Apoptosis in Culture Cells
Available online 12 August 2023, 106454Author links open overlay panel, , , , AbstractCisplatin, a widely prescribed chemo...
Cancer: Phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target
KeywordsPhosphodiesterase type 4 C (PDE4C)Cyclic Adenosine Monophosphate (cAMP)Post-translational modificationsBrain cance...
Development of a deep learning-based model to diagnose mixed-type gastric cancer accurately
Gastric cancer remains one of the leading causes of cancer and death worldwide. According to GLOBOCAN 2020 global cancer s...
Moonlighting functions of the ubiquitin-like protein, Hub1/UBL-5
Ubiquitin, a 76 amino acid protein (8.6 kDa), is conserved in eukaryotes but absent in bacteria and archaea. Ubiquitin con...
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