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The role of gut microbiota in infectious diseases
The role of gut microbiota in infectious diseases
Abstract The intestine, the largest immune organ in the human body, harbors approximately 1013 microorganisms, including b...
Systems biology of angiogenesis signaling: Computational models and omics
Systems biology of angiogenesis signaling: Computational models and omics
Abstract Angiogenesis is a highly regulated multiscale process that involves a plethora of cells, their cellular signal tr...
Modeling cholesterol metabolism and atherosclerosis
Modeling cholesterol metabolism and atherosclerosis
Abstract Atherosclerotic cardiovascular disease (ASCVD) is the leading cause of morbidity and mortality among Western popu...
Seven challenges in the multiscale modeling of multicellular tissues
Seven challenges in the multiscale modeling of multicellular tissues
Abstract The growth and dynamics of multicellular tissues involve tightly regulated and coordinated morphogenetic cell beh...
Tumor models in various Drosophila tissues
Tumor models in various Drosophila tissues
Abstract The development of cancer is a complex multistage process. Over the past few decades, the model organism Drosophi...
Computational anatomy and diffeomorphometry: A dynamical systems model of neuroanatomy in the soft condensed matter continuum
Computational anatomy and diffeomorphometry: A dynamical systems model of neuroanatomy in the soft condensed matter continuum
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Fluid mechanical modeling of the upper urinary tract
Fluid mechanical modeling of the upper urinary tract
Abstract The upper urinary tract (UUT) consists of kidneys and ureters, and is an integral part of the human urogenital sy...
Immunohistochemical evidence for adult human neurogenesis in health and disease
Immunohistochemical evidence for adult human neurogenesis in health and disease
Abstract Postnatal and adult neurogenesis in the subventricular zone and subgranular zone of animals such as rodents and n...
The sense of taste: Development, regeneration, and dysfunction
The sense of taste: Development, regeneration, and dysfunction
Abstract Gustation or the sense of taste is a primary sense, which functions as a gatekeeper for substances that enter the...
Complement and microglia dependent synapse elimination in brain development
Complement and microglia dependent synapse elimination in brain development
Abstract Synapse elimination, also known as synaptic pruning, is a critical step in the maturation of neural circuits duri...
Diversity of bet‐hedging strategies in microbial communities—Recent cases and insights
Diversity of bet‐hedging strategies in microbial communities—Recent cases and insights
Abstract Microbial communities are continuously exposed to unpredictable changes in their environment. To thrive in such d...
Trained immunity in the mucosal diseases
Trained immunity in the mucosal diseases
Abstract Immune memory is well known as a signature of the adaptive immune system. Recently, enhanced responses to subsequ...
Gut microbiota and inflammatory bowel disease
Gut microbiota and inflammatory bowel disease
Abstract Gut microbiota refers to the complex aggregation of microbes in gut, including bacteria, archaea, fungi, and viru...
The tumor immune microenvironments of HPV+ and HPV− head and neck cancers
The tumor immune microenvironments of HPV+ and HPV− head and neck cancers
Abstract Human papillomaviruses (HPVs) are the etiological agent of a significant, and increasing, fraction of head and ne...
Engineering extracellular vesicles for Alzheimer's disease: An emerging cell‐free approach for earlier diagnosis and treatment
Engineering extracellular vesicles for Alzheimer's disease: An emerging cell‐free approach for earlier diagnosis and treatment
Abstract Alzheimer's disease (AD) is a debilitating neurodegenerative disorder affecting over five million people globally...
The crucial role of model systems in understanding the complexity of cell signaling in human neurocristopathies
The crucial role of model systems in understanding the complexity of cell signaling in human neurocristopathies
Abstract Animal models are useful to study the molecular, cellular, and morphogenetic mechanisms underlying normal and pat...
Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family
Transferability of tigecycline resistance: Characterization of the expanding Tet(X) family
Abstract Tetracycline and its derivative tigecycline are clinical options against Gram-negative bacterial infections. The ...
Orexin, serotonin, and energy balance
Orexin, serotonin, and energy balance
Abstract The lateral hypothalamus is critical for the control of ingestive behavior and spontaneous physical activity (SPA...
An integrative multiscale view of early cardiac looping
An integrative multiscale view of early cardiac looping
Abstract The heart is the first organ to form and function during the development of an embryo. Heart development consists...
Cover Image, Volume 13, Issue 4
Cover Image, Volume 13, Issue 4
The cover image is based on the Advanced Review Cellular reprogramming: Mathematics meets medicine by Gabrielle A. Dotson ...
Thermoregulation: A journey from physiology to computational models and the intensive care unit
Thermoregulation: A journey from physiology to computational models and the intensive care unit
Abstract Thermoregulation plays a vital role in homeostasis. Many species of animals as well as humans have evolved variou...
Bioengineering tools for probing intracellular events in T lymphocytes
Bioengineering tools for probing intracellular events in T lymphocytes
Abstract T lymphocytes are the central coordinator and executor of many immune functions. The activation and function of T...
Circadian rhythms and the HPA axis: A systems view
Circadian rhythms and the HPA axis: A systems view
Abstract The circadian timing system comprises a network of time-keeping clocks distributed across a living host whose res...
Tools for computational analysis of moving boundary problems in cellular mechanobiology
Tools for computational analysis of moving boundary problems in cellular mechanobiology
Abstract A cell's ability to change shape is one of the most fundamental biological processes and is essential for maintai...
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