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Optogenetic engineering for ion channel modulation
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Lipid probes to study ion channels
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Stimuli-responsive synthetic ionophores for therapeutic applications
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Illuminating antifungal mode of action and resistance with fluorescent probes
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Recent advances in high-throughput screening methods for small molecule modulators in bacteria
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Corrigendum to “Enabling structural biological electron paramagnetic resonance spectroscopy in membrane proteins through spin labelling” Curr Opin Chem Biol 84 (2025) 102564
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Noncytotoxic catalytic enzyme functional mimics including cyanide poisoning antidotes
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Small-molecule tools for YEATS domain proteins
Small-molecule tools for YEATS domain proteins
Transcriptional co-regulatory proteins act on and through chromatin to control RNA polymerase activity [1]. These proteins...
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm
Recent advances in chemical synthesis of O-linked glycopeptides and glycoproteins: An advanced synthetic tool for exploring the biological realm
Post-translational modifications (PTMs) of proteins, such as methylation, phosphorylation, and glycosylation, have a profo...
Editorial overview: Glycobiology (2023)
Editorial overview: Glycobiology (2023)
Matthew Macauley is an associate professor within the Department of Chemistry at the University of Alberta and currently h...
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Strategies for quantifying the enzymatic activities of glycoside hydrolases within cells and in vivo
Enzymes mediate a great diversity of reactions that enable a wide range of cellular processes. The activities of enzymes w...
Nutritional metabolomics: Recent developments and future needs
Nutritional metabolomics: Recent developments and future needs
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Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Metabolic interventions to enhance immunotherapy and targeted therapy efficacy in advanced colorectal cancer
Current standard-of-care for metastatic colorectal cancer patients includes chemotherapy and anti-angiogenic or anti-epide...
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
Immunomodulatory roles of PARPs: Shaping the tumor microenvironment, one ADP-ribose at a time
PARPs encompass a small yet pervasive group of 17 enzymes that catalyze a post-translational modification known as ADP-rib...
Global approaches for protein thiol redox state detection
Global approaches for protein thiol redox state detection
Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence, cysteine often has important ...
Editorial overview: Imaging metal ions in biological systems
Editorial overview: Imaging metal ions in biological systems
Daniela Buccella. Dr. Buccella is a professor in the Department of Chemistry at New York University. She obtained her bach...
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation
Recent advances in mass spectrometry-based methods to investigate reversible cysteine oxidation
Within the past decade, the role of cysteine oxidation in organismal stress response has been established as a fundamental...
Recent chemical synthesis of plant polysaccharides
Recent chemical synthesis of plant polysaccharides
As the essential and most abundant biomolecules, carbohydrates are involved in the numerous biological processes with a va...
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Navigating the terrain of protein aggregation and phase separation - A chemical biology perspective
Cong Liu received his Ph.D. in Biochemistry from the Peking University, followed by a postdoc training at UCLA. He started...
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Recent advances in Zn2+ imaging: From organelles to in vivo applications
Zinc (Zn2+) is an important component of various proteins and plays important roles in many biological processes. It is bu...
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
A translational blueprint for developing intraoperative imaging agents via radiopharmaceutical-guided drug design
Curative oncologic surgery successfully removes all cancerous tissues from the body and is the most effective treatment mo...
Virus-assisted directed evolution of biomolecules
Billions of years of natural evolution has created an astounding variety of biomolecules with diverse structures and funct...
Advanced imaging techniques for studying protein phase separation in living cells and at single-molecule level
Proteins and nucleic acids undergo countless encounters in the cell. While some interactions exhibit well-defined stoichio...
Luminescent lanthanide probes for cations and anions: Promises, compromises, and caveats
Luminescent lanthanide probes, including those emitting in the visible (EuIII, TbIII, DyIII, and SmIII) and the infrared r...
Peptide-based molecules for the disruption of bacterial Hsp70 chaperones
The heat shock protein 70 (Hsp70) family aids in the maintenance of protein homeostasis, or proteostasis, across species. ...
Multimodal and multiscale correlative elemental imaging: From whole tissues down to organelles
‘Nature loves to hide’. These elegant words, written by Heraclitus of Ephesus about 2500 years ago, can be interpreted in ...
The redox riddle of selenium sulfide
There are quite a few movies which besides being highly entertaining also touch on real science. Apart from classics such ...
The influence of alkylating agents on sulfur–sulfur bonds in per- and polysulfides
Per- and polysulfides are sulfane sulfur species produced inside living cells, in organisms as diverse as bacteria, plants...
Highlights of bioinformatic tools and methods for validating bioinformatics derived hypotheses for microbial natural products research
Natural products (NPs) encompass various bioactive compounds originating from secondary metabolism in diverse organisms [1...
Recent advances towards mass spectrometry-based clinical lipidomics
The objective of this review is to provide a comprehensive summary of the latest methodological advancements and emerging ...
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