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Periprocedural Myocardial Injury in High‐Risk Patients With NSTEMI Pretreated With Ticagrelor for Less or More Than 6 Hours Before PCI
Periprocedural Myocardial Injury in High‐Risk Patients With NSTEMI Pretreated With Ticagrelor for Less or More Than 6 Hours Before PCI
Abstract We assessed the impact on periprocedural myocardial injury of a ticagrelor loading dose given <6 or >6 hour...
Association Between the Use of Sodium‐Glucose Cotransporter‐2 Inhibitors and Drug‐Induced Acute Kidney Injury: Analysis of 2 Databases
Association Between the Use of Sodium‐Glucose Cotransporter‐2 Inhibitors and Drug‐Induced Acute Kidney Injury: Analysis of 2 Databases
Abstract The association between the use of sodium-glucose cotransporter-2 (SGLT-2) inhibitors and the occurrence of drug-...
Efficacy and safety of adjunctive serotonin‐dopamine activity modulators in major depression: A meta‐analysis of randomized controlled trials
Efficacy and safety of adjunctive serotonin‐dopamine activity modulators in major depression: A meta‐analysis of randomized controlled trials
Abstract Serotonin dopamine activity modulators have been approved as an adjunctive treatment to antidepressants in patien...
An Empirical Analysis of Japan's Drug Development Lag Behind the United States
An Empirical Analysis of Japan's Drug Development Lag Behind the United States
Abstract The “Drug lag” (i.e., the approval lag for new drugs) hinders patients’ access to innovative...
Predictive Value of C‐Reactive Protein and Albumin for Temporal Within‐Individual Pharmacokinetic Variability of Voriconazole in Pediatric Hematopoietic Cell Transplant Patients
Predictive Value of C‐Reactive Protein and Albumin for Temporal Within‐Individual Pharmacokinetic Variability of Voriconazole in Pediatric Hematopoietic Cell Transplant Patients
Abstract Voriconazole is a widely used antifungal agent in immunocompromised patients, but its utility is limited by its v...
Population pharmacokinetics and exposure‐response relationships of astegolimab in patients with severe asthma
Population pharmacokinetics and exposure‐response relationships of astegolimab in patients with severe asthma
Abstract Astegolimab is a fully human immunoglobulin G2 monoclonal antibody (mAb) that binds to the ST2 receptor and block...
Heterogeneity in the identification of potential drug‐drug interactions in the intensive care unit: A systematic review, critical appraisal, and reporting recommendations
Heterogeneity in the identification of potential drug‐drug interactions in the intensive care unit: A systematic review, critical appraisal, and reporting recommendations
Abstract Patients admitted to the intensive care unit (ICU) are frequently exposed to potential drug-drug interactions (pD...
Clinical and pharmacological parameters determine relapse during clopidogrel treatment of acute coronary syndrome
Clinical and pharmacological parameters determine relapse during clopidogrel treatment of acute coronary syndrome
Abstract The therapeutic efficacy of clopidogrel as an anti-platelet drug varies among individuals, being the mainstream h...
Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function
Pharmacokinetics of Ipatasertib in Subjects With Hepatic Impairment Using 2 Methods of Classification of Hepatic Function
Abstract Ipatasertib is a highly selective small-molecule pan-Akt inhibitor in clinical development. Ipatasertib is predom...
A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure
A Population Pharmacokinetic Model of Vonoprazan: Evaluating the Effects of Race, Disease Status, and Other Covariates on Exposure
Abstract Vonoprazan, a potassium-competitive acid blocker, is under investigation in the US and Europe for the treatment o...
Neurological Immune Related Adverse Events Post‐COVID‐19 Vaccination: A Systematic Review
Neurological Immune Related Adverse Events Post‐COVID‐19 Vaccination: A Systematic Review
Abstract The COVID-19 pandemic has affected millions of individuals worldwide. The global scientific effort to design an e...
Different Kinetics of Activated Clotting Time among Uninterrupted Oral Anticoagulants during Catheter Ablation Procedure
Different Kinetics of Activated Clotting Time among Uninterrupted Oral Anticoagulants during Catheter Ablation Procedure
Abstract Activated clotting time (ACT) kinetics under uninterrupted oral anticoagulants (OACs) has not been fully evaluate...
Association between baseline use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers and death among patients tested for COVID‐19
Association between baseline use of angiotensin converting enzyme inhibitors and angiotensin receptor blockers and death among patients tested for COVID‐19
Abstract Angiotensin converting enzyme inhibitor (ACEI) and angiotensin receptor blocker (ARB) drugs may modify risk assoc...
Periprocedural Myocardial Injury in High‐Risk Patients with Non‐ST‐Elevation Myocardial Infarction Pre‐Treated with Ticagrelor for Less or More than 6 Hours Before PCI
Periprocedural Myocardial Injury in High‐Risk Patients with Non‐ST‐Elevation Myocardial Infarction Pre‐Treated with Ticagrelor for Less or More than 6 Hours Before PCI
Abstract We assessed the impact on periprocedural myocardial injury of a ticagrelor loading dose (LD) given less or more t...
Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment
Evaluation of the Pharmacokinetics and Safety of a Single Dose of Acalabrutinib in Subjects With Hepatic Impairment
Abstract Acalabrutinib received approval for treatment of adult patients with mantle cell lymphoma who received at least o...
Front‐Line Health Care Professionals Lack Critical Knowledge in Dietary Supplement and Nutraceutical Products: A Call to Action for Comprehensive Educational Opportunities
Front‐Line Health Care Professionals Lack Critical Knowledge in Dietary Supplement and Nutraceutical Products: A Call to Action for Comprehensive Educational Opportunities
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Infant dextromethorphan and dextrorphan exposure via breast milk from mothers who are CYP2D6 extensive metabolizers
Infant dextromethorphan and dextrorphan exposure via breast milk from mothers who are CYP2D6 extensive metabolizers
Abstract The risk of infant exposure to dextromethorphan (DM) and its active metabolite, dextrorphan (DX), through breast ...
Response to letter to the editor by Dr Robinson
Response to letter to the editor by Dr Robinson
Accepted Articles C. Michael White PharmD, FCP, FCCP, Corresponding Author ...
Conflation of Tuskegee Study with FDA Fiduciary Responsibilities Sensationally Ignores International Law
Conflation of Tuskegee Study with FDA Fiduciary Responsibilities Sensationally Ignores International Law
Accepted Articles PDF ShareShare ...
Pharmacological Arguments Against the Use of Ketamine in Nonmedical Settings
Pharmacological Arguments Against the Use of Ketamine in Nonmedical Settings
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MDMA‐Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta‐Analysis
MDMA‐Assisted Psychotherapy for Treatment of Posttraumatic Stress Disorder: A Systematic Review With Meta‐Analysis
Abstract This article discusses current literature on the use of 3,4-methylenedioxymethamphetamine (MDMA)-assisted psychot...
The effects of mannuronic acid on IL‐1β, IL‐17A, STAT1 and STAT3 gene expression and TLR2 and TLR4 molecules in multiple sclerosis
The effects of mannuronic acid on IL‐1β, IL‐17A, STAT1 and STAT3 gene expression and TLR2 and TLR4 molecules in multiple sclerosis
Abstract Multiple sclerosis (MS) is a chronic neurologic disease defined by inflammation and demyelination of the central ...
Risk of pregabalin‐induced hypoglycemia: Analysis of the Japanese Adverse Event Report database
Risk of pregabalin‐induced hypoglycemia: Analysis of the Japanese Adverse Event Report database
Abstract Pregabalin is a first-line treatment option for neuropathic pain. Recently, some cases of pregabalin-induced hypo...
Reassessing the Pediatric Dosing Recommendations for Unfractionated Heparin Using Real‐World Data: a Pharmacokinetic‐Pharmacodynamic Modeling Approach
Reassessing the Pediatric Dosing Recommendations for Unfractionated Heparin Using Real‐World Data: a Pharmacokinetic‐Pharmacodynamic Modeling Approach
Abstract Optimal pediatric dosing of unfractionated heparin (UFH) is challenging due to paucity of clinical outcome and ph...
Off‐label use of hydroxychloroquine in COVID‐19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance
Off‐label use of hydroxychloroquine in COVID‐19: analysis of reports of suspected adverse reactions from the Italian National Network of Pharmacovigilance
Abstract This study aimed to characterize adverse drug reactions (ADRs) to hydroxychloroquine in the setting of Covid-19, ...
Clearance of lormetazepam, midazolam, and their conjugated metabolites by continuous venovenous hemofiltration during prolonged sedation in critically ill patients with COVID‐19‐associated acute respiratory distress syndrome
Clearance of lormetazepam, midazolam, and their conjugated metabolites by continuous venovenous hemofiltration during prolonged sedation in critically ill patients with COVID‐19‐associated acute respiratory distress syndrome
Corresponding Author Department of Intensive Care, VieCuri Medical Center, Venlo, 5900 The ...
Pharmacokinetics and Concentration–Response of Dupilumab in Patients with Seasonal Allergic Rhinitis
Pharmacokinetics and Concentration–Response of Dupilumab in Patients with Seasonal Allergic Rhinitis
Abstract Patients with moderate to severe allergic rhinitis may benefit from subcutaneous immunotherapy (SCIT), despite th...
Risk of bleeding associated with nonsteroidal anti‐inflammatory drug use in patients exposed to antithrombotic therapy: a case‐crossover study
Risk of bleeding associated with nonsteroidal anti‐inflammatory drug use in patients exposed to antithrombotic therapy: a case‐crossover study
Abstract Concomitant nonsteroidal anti-inflammatory drug (NSAIDs) and antithrombotic drug use is associated with an increa...
Effect of Anti‐VEGF Therapy on the Disease Progression of Neovascular Age‐Related Macular Degeneration: A Systematic Review and Model‐Based Meta‐Analysis
Effect of Anti‐VEGF Therapy on the Disease Progression of Neovascular Age‐Related Macular Degeneration: A Systematic Review and Model‐Based Meta‐Analysis
Abstract Anti-vascular endothelial growth factor (VEGF) therapy is used to slow the disease progression of neovascular age...
Pain Management Considerations in Patients with Opioid Use Disorder Requiring Critical Care
Pain Management Considerations in Patients with Opioid Use Disorder Requiring Critical Care
Abstract The opioid epidemic has resulted in increased opioid-related critical care admissions, presenting challenges in a...
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