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Using estrogen and progesterone to treat premenstrual dysphoric disorder, postnatal depression and menopausal depression
1 IntroductionGonadal hormones–estrogen and progesterone–play critical roles in maintaining mental health across the lifes...
Disitamab vedotin combined with pyrotinib as salvage treatment in Her-2-amplified treatment refractory metastatic colorectal cancer: a case report
IntroductionColorectal cancer (CRC) is the second most lethal malignancy; it accounts for 9.4% of all cancer-related death...
Sesquiterpene lactones and cancer: new insight into antitumor and anti-inflammatory effects of parthenolide-derived Dimethylaminomicheliolide and Micheliolide
1 IntroductionMedicinal plants have long been revered for their therapeutic properties. These plants produce a wide variet...
The lower rate of bone and joint infection in patients with open extremity fractures associated with vaccination prior to injury: a propensity-matched cohort study
IntroductionBone and joint infections (BJIs) can lead to functional impairment and disability in patients and have a growi...
Synergistic effects of 6-shogaol and hyperthermia on ACHN renal cancer cells: modulation of ROS and heat shock pro-teins in cancer therapy
1 IntroductionThe incidence of kidney cancer has been steadily increasing worldwide, making it a major health concern in t...
Ginseng and Polygonum multiflorum formula protects brain function in Alzheimer’s disease
IntroductionAlzheimer’s disease (AD) is an age-related neurodegenerative disorder for which no effective treatments are cu...
Effect of hypoalbuminemia on drug pharmacokinetics
Highlights• Plasma concentration - amount of a drug present in the plasma, the liquid component of blood, at a given time....
Predicting new-onset stroke with machine learning: development of a model integrating traditional Chinese and western medicine
1 IntroductionStroke presents a significant global public health challenge, characterized by high incidence rates, substan...
Antibody-drug conjugate combinations in cancer treatment: clinical efficacy and clinical study perspectives
1 IntroductionCancer remains one of the leading causes of death worldwide, with millions of new diagnoses each year. Despi...
Elucidation of Callistemon lanceolatus-derived natural compounds in STAT 3 pathway against human cancer cells: in silico and in vitro studies
1 IntroductionCancer remains one of the most severe diseases globally, claiming more lives than any other disease (Chhikar...
Astragalus-containing Chinese herbal medicine used with Western medicine for lupus nephritis: a systematic review and meta-analysis of randomized controlled trials
IntroductionSystemic lupus erythematosus (SLE) is a chronic autoimmune disorder characterized by aberrant lymphocyte activ...
Exploration the therapeutic effects of sodium houttuyfonate combined with penicillin G on methicillin resistant staphylococcus aureus infected wounds
1 IntroductionStaphylococcus aureus, which can encode penicillin binding protein 2a (PBP2a) and cannot be inactivated by β...
Impacts of Chinese national centralized volume-based procurement policy targeting meropenem on prescription of designated antimicrobials for inpatients: an interrupted time series analysis
1 IntroductionIn China, a national centralized volume-based procurement policy (NCVBPP) targeting drugs has been issued an...
Treatment of pediatric central nervous system infection caused by carbapenem-resistant Klebsiella pneumoniae with ceftazidime/avibactam, two cases report and literature review
Treatment of pediatric central nervous system infection caused by carbapenem-resistant Klebsiella pneumoniae with ceftazidime/avibactam, two cases report and literature review
IntroductionBacterial resistance has become an increasingly serious problem in recent years, leading to a rapid rise in in...
MFAP4 is a novel prognostic biomarker in glioma correlating with immunotherapy resistance and ferroptosis
1 IntroductionGliomas are a diverse group of tumors that originate from the glial cells of the central nervous system and ...
Unveiling the therapeutic potential of berberine: its therapeutic role and molecular mechanisms in kidney diseases
1 IntroductionRenal damage is generally categorized into two main forms: acute kidney injury (AKI) and chronic kidney dise...
Adverse drug reactions to atezolizumab in combination with bevacizumab in hepatocellular carcinoma patients: an analysis of the food and drug administration adverse event reporting system database
The objective of the study is to systematically identify and evaluate the adverse drug reactions (ADRs) associated with th...
A narrative review on diagnosis and treatment of ifosfamide-induced encephalopathy, the perspective of a EURACAN reference center for sarcomas
Ifosfamide (IFO) is a nitrogen derivative used at different doses, alone or in combination, in the treatment of various ty...
The CYP2D6 phenotyping performance of single-point saliva metabolic ratio in a healthy Chinese Han population
1 IntroductionThe highly polymorphic gene CYP2D6 encodes the enzyme cytochrome P450 2D6, and the alleles can be classified...
Ehretia genus: a comprehensive review of its botany, ethnomedicinal values, phytochemistry, pharmacology, toxicology and clinical studies
1 IntroductionThe Ehretia genus, comprising 66 accepted species, belongs to the Boraginaceae family and is primarily distr...
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Editorial: Disease-on-a-chip: from point-of-care to personalized medicine
Miniaturization has played a pivotal role in driving innovation in microfluidic devices, particularly in their application...
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Phase-specific differential regulation of mechanical allodynia in a murine model of neuropathic pain by progesterone
Progesterone has been shown to have neuroprotective capabilities against a wide range of nervous system injuries, however ...
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Drug repositioning in thyroid cancer treatment: the intriguing case of anti-diabetic drugs
Cancer represents the main cause of death worldwide. Thyroid cancer (TC) shows an overall good rate of survival, however t...
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation the...
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
From the CONSORT to the ConPhyMP statement and beyond—how to ascertain best practice
With the implementation of the ConPhyMP reporting tool as an element of peer review in Frontiers in Pharmacology, Section ...
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
A phase I study to evaluate the safety, tolerability, and pharmacokinetics of a novel, potent GABA analog HSK16149 in healthy Chinese subjects
Purpose: HSK16149 is a novel, potent gamma-aminobutyric acid (GABA) analog for the treatment of neuropathic pain. This stu...
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis comorbid with atherosclerosis meets in lipid metabolism
Psoriasis (PSO) is a common skin disease affecting approximately 1%–3% of the population, and the incidence rate is increa...
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Case report: SAF-189s is a potent inhibitor in a lorlatinib-resistant NSCLC patient with acquired compound mutations ALK L1196M and D1203N
Acquired anaplastic lymphoma kinase (ALK) mutation is the major resistant mechanism to ALK tyrosine kinase inhibitors (TKI...
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Herbal formulas for detoxification and dredging collaterals in treating carotid atherosclerosis: a systematic review and meta-analysis
Objective: To systematically evaluate the efficacy and safety of the Chinese medicine detoxification and dredging collater...
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Physical activity influences adherence to pharmacological treatments in patients with severe mental disorders: results from the multicentric, randomized controlled LIFESTYLE trial
Introduction: Poor adherence to pharmacological treatment is frequent in people with severe mental disorders and it often ...
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