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Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
Neuro–bone tissue engineering: emerging mechanisms, potential strategies, and current challenges
The skeleton is a highly innervated organ in which nerve fibers interact with various skeletal cells. Peripheral nerve end...
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
Estradiol increases cortical and trabecular bone accrual and bone strength in an adolescent male-to-female mouse model of gender-affirming hormone therapy
The effects of gender-affirming hormone therapy on the skeletal integrity and fracture risk in transitioning adolescent tr...
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
MicroRNA-146a-loaded magnesium silicate nanospheres promote bone regeneration in an inflammatory microenvironment
Reconstruction of irregular oral-maxillofacial bone defects with an inflammatory microenvironment remains a challenge, as ...
A new perspective on intervertebral disc calcification—from bench to bedside
A new perspective on intervertebral disc calcification—from bench to bedside
Disc degeneration primarily contributes to chronic low back and neck pain. Consequently, there is an urgent need to unders...
The role and applications of extracellular vesicles in osteoporosis
The role and applications of extracellular vesicles in osteoporosis
Osteoporosis is a widely observed condition characterized by the systemic deterioration of bone mass and microarchitecture...
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Transcriptional reprogramming during human osteoclast differentiation identifies regulators of osteoclast activity
Enhanced osteoclastogenesis and osteoclast activity contribute to the development of osteoporosis, which is characterized ...
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Age-related secretion of grancalcin by macrophages induces skeletal stem/progenitor cell senescence during fracture healing
Skeletal stem/progenitor cell (SSPC) senescence is a major cause of decreased bone regenerative potential with aging, but ...
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Spatial analysis of the osteoarthritis microenvironment: techniques, insights, and applications
Osteoarthritis (OA) is a debilitating degenerative disease affecting multiple joint tissues, including cartilage, bone, sy...
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Risk of metabolic abnormalities in osteoarthritis: a new perspective to understand its pathological mechanisms
Although aging has traditionally been viewed as the most important risk factor for osteoarthritis (OA), an increasing amou...
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Lipolysis supports bone formation by providing osteoblasts with endogenous fatty acid substrates to maintain bioenergetic status
Bone formation is a highly energy-demanding process that can be impacted by metabolic disorders. Glucose has been consider...
Structure and function of the membrane microdomains in osteoclasts
Structure and function of the membrane microdomains in osteoclasts
The cell membrane structure is closely related to the occurrence and progression of many metabolic bone diseases observed ...
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Combining single-cell RNA sequencing and population-based studies reveals hand osteoarthritis-associated chondrocyte subpopulations and pathways
Hand osteoarthritis is a common heterogeneous joint disorder with unclear molecular mechanisms and no disease-modifying dr...
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Spatial transcriptomic interrogation of the murine bone marrow signaling landscape
Self-renewal and differentiation of skeletal stem and progenitor cells (SSPCs) are tightly regulated processes, with SSPC ...
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Annexin A5 derived from matrix vesicles protects against osteoporotic bone loss via mineralization
Matrix vesicles (MVs) have shown strong effects in diseases such as vascular ectopic calcification and pathological calcif...
Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice
Genetic interactions between polycystin-1 and Wwtr1 in osteoblasts define a novel mechanosensing mechanism regulating bone formation in mice
Molecular mechanisms transducing physical forces in the bone microenvironment to regulate bone mass are poorly understood....
Glycobiology in osteoclast differentiation and function
Glycobiology in osteoclast differentiation and function
Glycans, either alone or in complex with glycan-binding proteins, are essential structures that can regulate cell biology ...
Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling
Trim21 depletion alleviates bone loss in osteoporosis via activation of YAP1/β-catenin signaling
Despite the diverse roles of tripartite motif (Trim)-containing proteins in the regulation of autophagy, the innate immune...
Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort
Association of mineral and bone biomarkers with adverse cardiovascular outcomes and mortality in the German Chronic Kidney Disease (GCKD) cohort
Mineral and bone disorder (MBD) in chronic kidney disease (CKD) is tightly linked to cardiovascular disease (CVD). In this...
HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation
HuR-mediated nucleocytoplasmic translocation of HOTAIR relieves its inhibition of osteogenic differentiation and promotes bone formation
Bone marrow mesenchymal stem cell (BMSC) osteogenic differentiation and osteoblast function play critical roles in bone fo...
Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells
Prim-O-glucosylcimifugin ameliorates aging-impaired endogenous tendon regeneration by rejuvenating senescent tendon stem/progenitor cells
Adult tendon stem/progenitor cells (TSPCs) are essential for tendon maintenance, regeneration, and repair, yet they become...
Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis
Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S. aureus infection with osseointegration in murine models of implant-associated osteomyelitis
Eradication of MRSA osteomyelitis requires elimination of distinct biofilms. To overcome this, we developed bisphosphonate...
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Loss of Notch signaling in skeletal stem cells enhances bone formation with aging
Skeletal stem and progenitor cells (SSPCs) perform bone maintenance and repair. With age, they produce fewer osteoblasts a...
Osteomodulin downregulation is associated with osteoarthritis development
Osteomodulin downregulation is associated with osteoarthritis development
Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis (OA), and osteomodulin (OMD)...
Interoceptive regulation of skeletal tissue homeostasis and repair
Interoceptive regulation of skeletal tissue homeostasis and repair
Recent studies have determined that the nervous system can sense and respond to signals from skeletal tissue, a process kn...
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
Inhibiting WNT secretion reduces high bone mass caused by Sost loss-of-function or gain-of-function mutations in Lrp5
Proper regulation of Wnt signaling is critical for normal bone development and homeostasis. Mutations in several Wnt signa...
α-parvin controls chondrocyte column formation and regulates long bone development
α-parvin controls chondrocyte column formation and regulates long bone development
Endochondral ossification requires proper control of chondrocyte proliferation, differentiation, survival, and organizatio...
Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms
Phylobone: a comprehensive database of bone extracellular matrix proteins in human and model organisms
The bone extracellular matrix (ECM) contains minerals deposited on highly crosslinked collagen fibrils and hundreds of non...
Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression
Metformin accelerates bone fracture healing by promoting type H vessel formation through inhibition of YAP1/TAZ expression
Due to increasing morbidity worldwide, fractures are becoming an emerging public health concern. This study aimed to inves...
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
Identification of an intronic enhancer regulating RANKL expression in osteocytic cells
The bony skeleton is continuously renewed throughout adult life by the bone remodeling process, in which old or damaged bo...
Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain and osteoarthritis pain: a perspective of estrogen
Low back pain (LBP) is the world’s leading cause of disability and is increasing in prevalence more rapidly than any...
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