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Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
Quantitative Modelling in Stem Cell Biology and Beyond: How to Make Best Use of It
This article gives a broad overview of quantitative modelling approaches in biology and provides guidance on how to employ...
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
First Clinical Experiences Using Preconditioning Approaches to Improve MSC-Based Therapies
Describe the rationale for preconditioning MSCs prior to use as therapy and the state-of-the-art of using preconditioning ...
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
MSC-Based Cell Therapy for COVID-19-Associated ARDS and Classical ARDS: Comparative Perspectives
Despite no general conclusions regarding the therapeutic effect of MSCs on virus-induced acute lung injury in pre-clinical...
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
Human Stem Cells for Ophthalmology: Recent Advances in Diagnostic Image Analysis and Computational Modelling
To explore the advances and future research directions in image analysis and computational modelling of human stem cells (...
Machine Learning Approaches for Stem Cells
Machine Learning Approaches for Stem Cells
Machine learning (ML) enables high-throughput analysis of multimodal data generated from stem cell experiments such as gen...
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
Transcription Factors and Splice Factors—Interconnected Regulators of Stem Cell Differentiation
The underlying molecular mechanisms that direct stem cell differentiation into fully functional, mature cells remain an ar...
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Understanding Hematopoietic Stem Cell Dynamics—Insights from Mathematical Modelling
Hematopoietic stem cells (HSCs) drive blood-cell production (hematopoiesis). Out-competition of HSCs by malignant cells oc...
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review
The Efficacy of Intra-articular Umbilical Cord-Mesenchymal Stem Cell Injection for Knee Osteoarthritis: a Systematic Review
Previous studies involving various mesenchymal stem cell (MSC) sources have reported osteoarthritis (OA) attenuation benef...
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
A Review of Stochastic and Deterministic Modeling of Stem Cell Dynamics
This paper briefly describes recent mathematical models that use stochastic and deterministic approaches to understand ste...
Stem Cell Banking of Adipose Tissue
Stem Cell Banking of Adipose Tissue
Adult stem cells such as adipose tissue derived cells (ASCs) are often preferred for autologous cellular therapies. Nevert...
Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
Immune Editing: Overcoming Immune Barriers in Stem Cell Transplantation
Human pluripotent stem cells have the potential to revolutionize the treatment of inborn and degenerative diseases, includ...
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
Applying the Cytocentric Principles to Regenerative Medicine for Reproducibility
Cell and tissue products do not just reflect their present conditions; they are the culmination of all they have encounter...
Organoid Technologies for SARS-CoV-2 Research
Organoid Technologies for SARS-CoV-2 Research
Organoids are an emerging technology utilizing three-dimensional (3D), multi-cellular in vitro models to represent the fun...
The Effects of Different Regenerative Treatments after Tooth Avulsion
The Effects of Different Regenerative Treatments after Tooth Avulsion
Traumatic injury to the teeth can cause dental avulsion. There is little time to return the tooth to its socket. Also, aft...
Advances in Biomaterials for Promoting Vascularization
Advances in Biomaterials for Promoting Vascularization
Tissue engineered constructs (TECs)—commonly developed using natural or synthetic biomaterials—are crucially n...
Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine
Cardiovascular Imaging Databases: Building Machine Learning Algorithms for Regenerative Medicine
Myocardial regeneration is a promising alternative to heart transplantation, but the ideal stem cell type remains unknown ...
Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview
Interaction of Radiotherapy and Hyperthermia with the Immune System: a Brief Current Overview
This review focuses on the opposing effects on the immune system of radiotherapy (RT) and the consequences for combined ca...
Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE)
Impact of Age, Sex, and Genetic Diversity in Murine Models of the Hematopoietic Acute Radiation Syndrome (H-ARS) and the Delayed Effects of Acute Radiation Exposure (DEARE)
Malicious or accidental radiation exposure increases risk for the hematopoietic acute radiation syndrome (H-ARS) and the d...
Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis
Utilizing Carbon Ions to Treat Medulloblastomas that Exhibit Chromothripsis
Novel radiation therapies with accelerated charged particles such as protons and carbon ions have shown encouraging result...
Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics
Impact of Cryopreservation and Freeze-Thawing on Therapeutic Properties of Mesenchymal Stromal/Stem Cells and Other Common Cellular Therapeutics
Cryopreservation and its associated freezing and thawing procedures–short “freeze-thawing”–are amo...
Decoding Human Hematopoietic Stem Cell Self-Renewal
Decoding Human Hematopoietic Stem Cell Self-Renewal
Hematopoietic stem cells (HSCs) maintain blood and immune cell homeostasis by balancing quiescence, self-renewal, and diff...
Creation and Development of Patient-Derived Organoids for Therapeutic Screening in Solid Cancer
Creation and Development of Patient-Derived Organoids for Therapeutic Screening in Solid Cancer
Clinical implementation of personalized cancer therapy necessitates translational cancer models that faithfully represent ...
Are Mesenchymal Stem Cells Fibroblasts with Benefits?
Are Mesenchymal Stem Cells Fibroblasts with Benefits?
Mesenchymal stem or stromal cells (MSCs) are a heterogeneous group of non-hematopoietic, multipotent progenitor cells that...
Clinical Manufacturing of Human Mesenchymal Stromal Cells using a Potency-Driven Paradigm
Clinical Manufacturing of Human Mesenchymal Stromal Cells using a Potency-Driven Paradigm
In this review, we discuss the current state of scalable manufacturing of a reproducible and potent allogeneic MSC product...
Hypoxia and Hematopoiesis
Hypoxia and Hematopoiesis
Hematopoietic stem and progenitor cells (HSC/HSPCs) originate in bone marrow (BM) niches and facilitate immune cell produc...
In Utero Gene Editing for Inherited Lung Diseases
In Utero Gene Editing for Inherited Lung Diseases
In utero gene editing has unique potential to treat monogenic lung diseases efficiently and before the need for lung funct...
MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel
MSCs in Space: Mesenchymal Stromal Cell Therapeutics as Enabling Technology for Long-Distance Manned Space Travel
Advancements in space travel, such as space tourism into Earth’s orbit, but also the prospect of long-distance manne...
The Fetal Hematopoietic Niche: Components and Mechanisms for Hematopoietic Stem Cell Emergence and Expansion
The Fetal Hematopoietic Niche: Components and Mechanisms for Hematopoietic Stem Cell Emergence and Expansion
Hematopoiesis is the process of generating all blood and immune cells, which is fueled at the root by self-renewing multip...
Role of the Hematopoietic Stem Cells in Immunological Memory
Role of the Hematopoietic Stem Cells in Immunological Memory
Immunological memory is an important evolutionary adaptation of the immune system. Previously restricted to the adaptive i...
Integration of Mechanical and ECM Microenvironment Signals in the Determination of Cancer Stem Cell States
Integration of Mechanical and ECM Microenvironment Signals in the Determination of Cancer Stem Cell States
Cancer stem cells (CSCs) are increasingly understood to play a central role in tumor progression. Growing evidence implica...
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