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Pricey sickle cell gene therapies primed for change
Bluebird Bio and Vertex Pharmaceuticals are the first to participate in a scheme to enable people with sickle cell disease...
Mushroom makes tasty eco-asphalt
Mushroom makes tasty eco-asphalt
Bicycle lanes, car parks and roads in Denmark will soon sport earth-friendly...
Liver-avoiding capsids draw $1.1 billion
Novartis is shoring up its portfolio on gene therapies for inherited neuromuscular diseases by acquiring Kate Therapeutics...
Fresh from the biotech pipeline: FDA approvals settle in 2024, but what next?
Fresh from the biotech pipeline: FDA approvals settle in 2024, but what next?
After two volatile years, FDA approvals in 2024 settled closer to their 10-year average. Will nominated commissioner Marty...
A platform for the biomedical application of large language models
A platform for the biomedical application of large language models
Heidelberg University, Faculty of Medicine and Heidelberg University Hospital, Institute for Computational Biomedicine, He...
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors
Quantum-computing-enhanced algorithm unveils potential KRAS inhibitors
We introduce a quantum–classical generative model for small-molecule design, specifically targeting KRAS inhibitors ...
Uniform volumetric single-cell processing for organ-scale molecular phenotyping
Uniform volumetric single-cell processing for organ-scale molecular phenotyping
Extending single-cell analysis to intact tissues while maintaining organ-scale spatial information poses a major challenge...
A monomeric StayGold fluorescent protein
A monomeric StayGold fluorescent protein
StayGold is an exceptionally bright and stable fluorescent protein that is highly resistant to photobleaching. Despite fav...
From AI to the Y chromosome (and everything in between)
Nature Biotechnology editors pick their favorite research articles from 2023.
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s academic spinouts 2022
Nature Biotechnology’s annual survey highlights academic start ups that are, among other things, correcting misfolde...
The world’s first CRISPR therapy is approved: who will receive it?
The go-ahead for Vertex’s gene editing therapy in sickle cell disease and β-thalassemia is a historic milestone, but this ...
Tracing the fate of AAV vectors in the body
Tracing the fate of AAV vectors in the body
A study of AAV gene therapy in monkeys proposes that integrated vectors may drive long-term transgene expression.
DNA nanodevices map intracellular ions
DNA nanodevices map intracellular ions
Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium acti...
Top ten news stories in 2023
Our ranking is out, and it has a few surprises. In pole position — predictably — is Wegovy, the weight-slashin...
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Encapsulated stem cell–derived β cells exert glucose control in patients with type 1 diabetes
Clinical studies on the treatment of type 1 diabetes with device-encapsulated pancreatic precursor cells derived from huma...
Spatial methods for microbiome–host interactions
Spatial methods for microbiome–host interactions
Spatial transcriptomics offers a glimpse of how microbiomes interact with their hosts.
Spatial host–microbiome sequencing reveals niches in the mouse gut
Spatial host–microbiome sequencing reveals niches in the mouse gut
Mucosal and barrier tissues, such as the gut, lung or skin, are composed of a complex network of cells and microbes formin...
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
Spatial metatranscriptomics resolves host–bacteria–fungi interactomes
The interactions of microorganisms among themselves and with their multicellular host take place at the microscale, formin...
Modeling human trunk development
Modeling human trunk development
A model of the embryonic human trunk attains a more mature developmental stage than previous models.
Antibiotic nanoparticles boost antitumor immunity
Antibiotic nanoparticles boost antitumor immunity
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T ce...
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Generation of locus coeruleus norepinephrine neurons from human pluripotent stem cells
Central norepinephrine (NE) neurons, located mainly in the locus coeruleus (LC), are implicated in diverse psychiatric and...
A bacterial assist for CAR-T cells
Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obta...
Precise intraoperative brain tumor classification
Central nervous system (CNS) tumors are a leading cause of cancer-related deaths, particularly among children, and the pri...
Antibody engineering
Recent patents relating to the manufacture and design of engineered immunoglobulin polypeptides.
NKs for lupus poised for trial
Nkarta is charting a course for its allogeneic chimeric antigen receptor (CAR) natural killer cell (NK) therapy in autoimm...
Chan Zuckerberg hubs multiply
In October, the Chan Zuckerberg Initiative (CZI) launched two new biohubs: one in New York and another in Chicago. The bio...
Most effective malaria vaccine yet
A new malaria vaccine for children is the first to meet the World Health Organization’s (WHO) 75% protection target. The v...
Brain imaging turned inside out
Brain imaging turned inside out
Neural connectivity in brain tissue is imaged by labeling the extracellular space.
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
Systematic discovery of neoepitope–HLA pairs for neoantigens shared among patients and tumor types
The broad application of precision cancer immunotherapies is limited by the number of validated neoepitopes that are commo...
Imaging glycosylated RNAs at the subcellular scale
Imaging glycosylated RNAs at the subcellular scale
A recently discovered RNA species on the cell surface is studied by proximity ligation.
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