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Exome analyses unravel the genetic architecture of Mendelian dominant nonsyndromic orofacial clefts
Nonsyndromic orofacial clefts (NSOFC) represents a prevalent congenital anomalies, the etiology of which likely involves a...
Identification of potential modulators of intrauterine adhesion pathogenesis with RNA sequencing, histology and in vitro assays
Intrauterine adhesion (IUA), also referred to as intrauterine stenosis or synechiae, is a prevalent gynecological issue, w...
Molecular insights into temperature-driven color variation in Stropharia rugosoannulata mushrooms
The data generated for the current study was submitted to the public domain. Current study data is available on NCBI platf...
16S rDNA sequencing reveal synergistic effects of silkworm feces and earthworms on nutrient-poor soil microbial community structure and function in Guangxi
Author links open overlay panel, , , , , Highlights•Silkworm feces and earthworms synergistically enhance soil microbial d...
Comprehensive expression genome-wide association study of long non-coding RNAs in four porcine tissues
BackgroundLong non-coding RNAs (lncRNAs), a type of non-coding RNA molecules, are known to play critical regulatory roles ...
Identification of blacklist regions in cattle and pig genomes
Cattle and pigs are important farm animals and biomedical models for studying human development and diseases. Accurate ann...
Gap-free genome assembly and comparative analysis reveal the evolution and lignin degradation mechanisms of Cylindrobasidium torrendii
The Physalacriaceae family comprises numerous saprophytic edible and medicinal fungi with significant ecological and econo...
Integrated analysis of single-cell and bulk RNA sequencing identifies APOC1 as a biomarker and therapeutic target for G0/G1 cell cycle arrest in cholangiocarcinoma
Cholangiocarcinoma is characterized by its high malignancy, frequent recurrence and insensitivity to conventional radiothe...
Genomic insights and phylogenetics of the mitochondrial genome of Cryptocarya
The tropical genus Cryptocarya is known for its valuable timber and the constituents in these trees show potential for med...
METTL14 facilitates the process of sexual reversal via m6A RNA methylation in Pelodiscus sinensis
The Chinese soft-shelled turtle (Pelodiscus sinensis, P. sinensis) demonstrates noteworthy sexual dimorphism, where the ma...
Integrated analysis of lipid metabolism and differentially expressed genes reveal seed oil accumulation in field muskmelon
Field muskmelon (Cucumis melo L. var. agrestis Naud.), a novel oil crop, contains a high amount of lipids in seeds. Howeve...
Deep sequencing of Korean Jindo dog reveals evolutionary trajectory of coat color variations
The inherent diversity of canines is closely intertwined with the unique color patterns of each dog population. These vari...
Transcriptome and metabolome reveal the mechanism of neuroendocrine regulation in ovarian development of broiler breeders
The long-term selection for meat has led to the poor egg production efficiency in broiler. In this study, we analyzed the ...
Transcriptome analysis reveals that the injection of mesenchymal stem cells remodels extracellular matrix and complement components of the brain through PI3K/AKT/FOXO1 signaling pathway in a neuroinflammation mouse model
Author links open overlay panel, , , , , , , Highlights•The brains of mice that received injections of LPS and MSCs were s...
Insights for variant clinical interpretation based on a benchmark of 65 variant effect predictors
Single amino acid substitutions in protein sequences are generally harmless, but a certain number of these changes can lea...
The noncausal association between a loss-of-function CLCN2 variant and childhood absence epilepsy
The datasets generated during the current study are available in the ClinVar repository with the primary accession codes S...
Feadm5C: Enhancing prediction of RNA 5-Methylcytosine modification sites with physicochemical molecular graph features
One common post-transcriptional modification that is essential to biological activities is RNA 5-methylcytosine (m5C). A l...
Heterogeneity of fibroblasts from different anatomical sites in healthy human knee ligaments revealed by single-cell RNA sequencing
Knee ligaments are important structures that determine the locomotor function of the knee. In this paper, we identified an...
Resveratrol-stimulated macrophage exosomes delivering lncRNA Snhg6 inhibit liver fibrosis by modulating the NF-κB pathway
ObjectiveTo investigate the role of lncRNA Snhg6 in liver fibrosis, delivered by resveratrol-stimulated macrophage exosome...
Maternal genetic architecture of Guizhou's Hmong-Mien populations via whole mitogenome
Author links open overlay panel, , , , , , , , , , , , , Highlights•The B4a5 might be the maternal founding lineage of the...
DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition
DOT1L decelerates the development of osteoporosis by inhibiting SRSF1 transcriptional activity via microRNA-181-mediated KAT2B inhibition
KeywordsOsteoporosisDOT1LMicroRNA-181Lysine acetyltransferase 2BSerine and arginine rich splicing factor 1Osteogenic diffe...
Expression profiles of lncRNAs, miRNAs, and mRNAs and interaction analysis indicates their potential involvment during testicular fusion in Spodoptera litura
Expression profiles of lncRNAs, miRNAs, and mRNAs and interaction analysis indicates their potential involvment during testicular fusion in Spodoptera litura
KeywordsTesticular fusionNon-coding RNAscAMP signal pathwayECM remodelingInducible metalloproteinase inhibitor protein (IM...
Using two self-developed InDel panels to explore forensic feature and population genetic structure in the Hui group
Using two self-developed InDel panels to explore forensic feature and population genetic structure in the Hui group
To address the challenges faced by forensic examiners in degraded DNA analysis, we have developed two different panels for...
RNA-Seq profiling of circular RNAs in mice with lipopolysaccharide-induced acute lung injury
RNA-Seq profiling of circular RNAs in mice with lipopolysaccharide-induced acute lung injury
KeywordsHigh-throughput RNA sequencingAcute lung injuryCircular RNAscircRNA-miRNA-mRNA networkCompeting endogenous RNAAbbr...
Whole genome sequencing of Crassostrea ariakensis (Mollusca: Ostreidae) and C. hongkongensis expands understandings of stress resistance in sessile oysters
Whole genome sequencing of Crassostrea ariakensis (Mollusca: Ostreidae) and C. hongkongensis expands understandings of stress resistance in sessile oysters
To understand the environmental adaptations among sessile bivalves lacking adaptive immunity, a series of analyses were co...
Sex-specific transcriptome of the chicken chorioallantoic membrane
Sex-specific transcriptome of the chicken chorioallantoic membrane
Dimorphism between male and female embryos has been demonstrated in many animal species, including chicken species. Likewi...
Transcriptomic and metabolomic analyses reveal that lemon extract prolongs Drosophila lifespan by affecting metabolism
Transcriptomic and metabolomic analyses reveal that lemon extract prolongs Drosophila lifespan by affecting metabolism
Ageing is an evolutionarily conserved and irreversible biological process in different species. Numerous studies have repo...
LncRNA FIRRE regulated endometrial cancer radiotherapy sensitivity via the miR-199b-5p/SIRT1/BECN1 axis-mediated autophagy
LncRNA FIRRE regulated endometrial cancer radiotherapy sensitivity via the miR-199b-5p/SIRT1/BECN1 axis-mediated autophagy
BackgroundEndometrial cancer (EC) poses a serious threat to women's health. Radiotherapy has been widely used for EC treat...
MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks
MetaAc4C: A multi-module deep learning framework for accurate prediction of N4-acetylcytidine sites based on pre-trained bidirectional encoder representation and generative adversarial networks
MotivationN4-acetylcytidine (ac4C) is a highly conserved RNA modification that plays a crucial role in various biological ...
Multi-omics network analysis on samples from sequential biopsies reveals vital role of proliferation arrest for Macrosteatosis related graft failure in rats after liver transplantation
Multi-omics network analysis on samples from sequential biopsies reveals vital role of proliferation arrest for Macrosteatosis related graft failure in rats after liver transplantation
DEGsdifferentially expressed genesDEMsdifferentially expressed metabolitesEdU5-Ethynyl-2′-deoxyuridineIRIischemia/reperfus...
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