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TASK inhibition by mild acidosis increases Ca2+ oscillations to mediate pH sensing in rat carotid body chemoreceptor cells
TASK inhibition by mild acidosis increases Ca2+ oscillations to mediate pH sensing in rat carotid body chemoreceptor cells
Severe levels of acidosis (pH<6.8) have been shown to cause a sustained rise in cytosolic Ca2+ concentration in carotid...
Menthol Flavoring in E-Cigarette Condensate Causes Pulmonary Dysfunction and Cytotoxicity in Precision Cut Lung Slices
Menthol Flavoring in E-Cigarette Condensate Causes Pulmonary Dysfunction and Cytotoxicity in Precision Cut Lung Slices
E-cigarette consumption is under scrutiny by regulatory authorities due to concerns about product toxicity, lack of manufa...
Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)
Magnetic resonance imaging-based scoring of the diseased lung in the preterm infant with bronchopulmonary dysplasia: UNiforme Scoring of the disEAsed Lung in BPD (UNSEAL BPD)
Neonatal chronic lung disease lacks standardized assessment of lung structural changes. We addressed this clinical need by...
α1 adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with IPF
α1 adrenoreceptor antagonism mitigates extracellular mitochondrial DNA accumulation in lung fibrosis models and in patients with IPF
Idiopathic Pulmonary Fibrosis is increasingly associated with nerve-driven processes and endogenous innate immune ligands ...
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS
Plasma metabolic profiling implicates dysregulated lipid metabolism and glycolytic shift in hyperinflammatory ARDS
Using latent class analysis (LCA) of clinical and protein biomarkers, researchers have identified two phenotypes of the ac...
Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema
Indocyanine-enhanced mouse model of bleomycin-induced lung fibrosis with hallmarks of progressive emphysema
The development of new drugs for Idiopathic Pulmonary Fibrosis strongly relies on preclinical experimentation, which requi...
Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity
Transcriptomic and proteomic profiling of young and old mice in the bleomycin model reveals high similarity
The most common preclinical, in vivo model to study lung fibrosis is the bleomycin-induced lung fibrosis model in 2-3-mont...
Myofibroblast-Specific Inhibition of the Rho Kinase-MRTF-SRF Pathway Using Nanotechnology for the Prevention of Pulmonary Fibrosis
Myofibroblast-Specific Inhibition of the Rho Kinase-MRTF-SRF Pathway Using Nanotechnology for the Prevention of Pulmonary Fibrosis
Pulmonary fibrosis is characterized by the accumulation of myofibroblasts in the lung and progressive tissue scarring. Fib...
Diet-Induced Obesity Worsens Allergen-Induced Type 2/Type 17 Inflammation in Airways by Enhancing DUOX1 Activation
Diet-Induced Obesity Worsens Allergen-Induced Type 2/Type 17 Inflammation in Airways by Enhancing DUOX1 Activation
More than 50% of people with asthma in the US are obese, and obesity often worsens symptoms of allergic asthma and impairs...
Complex roles of TGF-beta signaling pathways in lung development and bronchopulmonary dysplasia
Complex roles of TGF-beta signaling pathways in lung development and bronchopulmonary dysplasia
As survival of extremely preterm infants continues to improve, there is also an associated increase in bronchopulmonary dy...
Call for Papers: “Targeting Airway Immunity in Lung Disease”
Call for Papers: “Targeting Airway Immunity in Lung Disease”
Received 17 November 2022 ...
The diversity of neuroimmune circuits controlling lung inflammation
The diversity of neuroimmune circuits controlling lung inflammation
It is becoming increasingly appreciated that the nervous and immune systems communicate bidirectionally to regulate immuno...
Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis
Differential remodelling in small and large murine airways revealed by novel whole lung airway analysis
Airway remodelling occurs in chronic asthma leading to increased airway smooth muscle (ASM) mass and extra-cellular matrix...
Comparison of Different Methods of Initiating Lung Inflammation and the Sex-Specific Effects on Inflammatory Parameters
Comparison of Different Methods of Initiating Lung Inflammation and the Sex-Specific Effects on Inflammatory Parameters
Sex as a biological variable is an essential element of preclinical research. Sex-specific differences in lung volume, alv...
The ultimate trade-off: How red cell adaptations to malaria may alter the host response during critical illness
The ultimate trade-off: How red cell adaptations to malaria may alter the host response during critical illness
The human immune system evolved in response to pathogens. Amongst these pathogens, malaria has proven to be one of the dea...
The matricellular protein CCN3 supports lung endothelial homeostasis and function
The matricellular protein CCN3 supports lung endothelial homeostasis and function
Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmon...
Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasia
Neonatal hyperoxia induces activated pulmonary cellular states and sex-dependent transcriptomic changes in a model of experimental bronchopulmonary dysplasia
Hyperoxia disrupts lung development in mice and causes bronchopulmonary dysplasia (BPD) in neonates. To investigate sex-de...
Integral Assessment of Gas Exchange During Veno-Arterial ECMO - Accuracy and Precision of a Modified Fick Principle in a Porcine Model
Integral Assessment of Gas Exchange During Veno-Arterial ECMO - Accuracy and Precision of a Modified Fick Principle in a Porcine Model
Assessment of native cardiac output during extracorporeal circulation is challenging. We assessed a modified Fick principl...
Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice
Mitoquinone mesylate attenuates pathologic features of lean and obese allergic asthma in mice
Obesity is associated with severe, difficult to control asthma, and increased airway oxidative stress. Mitochondrial react...
Microvascular lung injury and endoplasmic reticulum stress in systemic lupus erythematosus-associated alveolar hemorrhage and pulmonary vasculitis
Microvascular lung injury and endoplasmic reticulum stress in systemic lupus erythematosus-associated alveolar hemorrhage and pulmonary vasculitis
Human COPA mutations affecting retrograde Golgi-to-endoplasmic reticulum (ER) protein transport cause diffuse alveolar hem...
Call for Papers: “In It for the Long Haul: Understanding the Lasting Impact of COVID-19 on Lung Health and Disease”
Call for Papers: “In It for the Long Haul: Understanding the Lasting Impact of COVID-19 on Lung Health and Disease”
Received 20 October 2022 ...
Noncanonical JAK1/STAT3 interactions with TGF-β modulate myofibroblast transdifferentiation and fibrosis
Noncanonical JAK1/STAT3 interactions with TGF-β modulate myofibroblast transdifferentiation and fibrosis
Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease with limited survival. Janus kinases (JAKs), tyrosine ki...
Congenital heart disease-associated pulmonary dysplasia and its underlying mechanisms
Congenital heart disease-associated pulmonary dysplasia and its underlying mechanisms
Clinical observation indicates that exercise capacity, an important determinant of survival in patients with congenital he...
Development of a Peripheral Blood Transcriptomic Gene Signature to Predict Bronchopulmonary Dysplasia
Development of a Peripheral Blood Transcriptomic Gene Signature to Predict Bronchopulmonary Dysplasia
Background: Bronchopulmonary dysplasia (BPD) is the most common lung disease of extreme prematurity, yet mechanisms that a...
Distribution, composition and activity of airway-associated adipose tissue in the porcine lung
Distribution, composition and activity of airway-associated adipose tissue in the porcine lung
Patients with comorbid asthma-obesity experience greater disease severity and are less responsive to therapy. We have prev...
Understanding the role of placental pathophysiology in the development of bronchopulmonary dysplasia
Understanding the role of placental pathophysiology in the development of bronchopulmonary dysplasia
The associations between bronchopulmonary dysplasia (BPD) and the gestational pathologies of chorioamnionitis (CA) and hyp...
Post-hoc survival analyses using RNAseq data: handle with care
Post-hoc survival analyses using RNAseq data: handle with care
With the advent of next-generation sequencing technologies, there has been an dramatic increase in the avilability of pair...
Activation of TREK-1 (K2P2.1) Potassium Channels Protects Against Influenza A-Induced Lung Injury
Activation of TREK-1 (K2P2.1) Potassium Channels Protects Against Influenza A-Induced Lung Injury
Influenza-A virus (IAV) infects yearly an estimated one billion people worldwide, resulting in 300,000-650,000 deaths. Pre...
The diversity of neuro-immune circuits controlling lung inflammation
The diversity of neuro-immune circuits controlling lung inflammation
It is becoming increasingly appreciated that the nervous and immune systems communicate bidirectionally to regulate immuno...
MRI based scoring of the diseased lung in the preterm infant with BPD
MRI based scoring of the diseased lung in the preterm infant with BPD
Objective: Neonatal chronic lung disease lacks standardised assessment of lung structural changes. Method and Results: We ...
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