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Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Mucus Transpiration as the Basis for Chronic Cough and Cough Hypersensitivity
Chronic cough is characterized by a state of cough hypersensitivity. We analyze the process of transpiration, by which wat...
Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)
Efficacy and Safety of Re-administration of Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor (EGFR-TKI) After EGFR-TKI-Induced Interstitial Lung Disease (CS-Lung-005)
This study investigated the safety and efficacy of epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitor (TKI)...
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
Predictors of Early and Late Lung Function Improvement in Severe Eosinophilic Asthma on Type2-Biologics in the PRISM Study
The determinants linked to the short- and long-term improvement in lung function in patients with severe eosinophilic asth...
The Therapeutic Landscape in Chronic Cough
The Therapeutic Landscape in Chronic Cough
In recent years, there has been a substantial increase in the development of antitussive therapies and the first new&n...
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Elevated Eosinophil Counts in Acute Exacerbations of Bronchiectasis: Unveiling a Distinct Clinical Phenotype
Non-cystic fibrosis bronchiectasis is a chronic respiratory disease characterized by bronchial dilation. However, the sign...
Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
Cardiovascular Events with the Use of Long-Acting Muscarinic Receptor Antagonists: An Analysis of the FAERS Database 2020–2023
This study aimed to examine reports of cardiovascular adverse events (CV AEs) observed in the real-world during treatment ...
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
Missing Nuts and Bolts: Translating Pulmonary Fibrosis from Preclinical Murine Models to Human Clinical Trials
IKS is supported in part by the National Institutes of Health NIH R01HL142543, the National Institute of General Medical S...
Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
Identification of Idiopathic Pulmonary Fibrosis and Prediction of Disease Severity via Machine Learning Analysis of Comprehensive Metabolic Panel and Complete Blood Count Data
Diagnosis of idiopathic pulmonary fibrosis (IPF) typically relies on high-resolution computed tomography imaging (HRCT) or...
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Characterization of Codeine Treatment Responders Among Patients with Refractory or Unexplained Chronic Cough: A Prospective Real-World Cohort Study
Codeine is a narcotic antitussive often considered for managing patients with refractory or unexplained chronic cough. Thi...
Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
Genetic Testing Goes Beyond Imaging and Histological Evaluation in Pleuroparenchymal Fibroelastosis
Lung biopsy remains the gold standard in the diagnosis of fibrotic interstitial lung disease (F-ILD), but there is a growi...
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Pressure Support Ventilation Versus T-piece as Spontaneous Breathing Trials for Extubation of Patients with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Weaning patients with COPD from mechanical ventilation (MV) presents a challenge, as literature on this topic is limited. ...
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Circulating Osteopontin Predicts Clinical and Radiological Response in First-Line Treatment of Advanced Non-Small Cell Lung Cancer
Pembrolizumab-based regimens are conditioned by the expression of PD-L1, but durable response rate is limited by innate an...
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
Human Bronchial Epithelial Cell Transcriptome Changes in Response to Serum from Patients with Different Status of Inflammation
To investigate the transcriptome of human bronchial epithelial cells (HBEC) in response to serum from patients with differ...
Asymptomatic Dysphagia and Aspiration in Patients with Idiopathic Bronchiectasis
Asymptomatic Dysphagia and Aspiration in Patients with Idiopathic Bronchiectasis
Although considered contributors to idiopathic bronchiectasis (IB), neither dysphagia nor silent aspiration have been syst...
Osteopontin: A Novel Therapeutic Target for Respiratory Diseases
Osteopontin: A Novel Therapeutic Target for Respiratory Diseases
Osteopontin (OPN) is a multifunctional phosphorylated protein that is involved in physiological and pathological events. E...
Diaphragm Ultrasonography: Reference Values and Influencing Factors for Thickness, Thickening Fraction, and Excursion in the Seated Position
Diaphragm Ultrasonography: Reference Values and Influencing Factors for Thickness, Thickening Fraction, and Excursion in the Seated Position
Measurements of diaphragm function by ultrasonography are affected by body position, but reference values in the seated po...
Predictors of Initial CPAP Prescription and Subsequent Course with CPAP in Patients with Central Sleep Apneas at a Single Center
Predictors of Initial CPAP Prescription and Subsequent Course with CPAP in Patients with Central Sleep Apneas at a Single Center
Guidelines recommend considering an initial trial of continuous positive airway pressure (CPAP) to treat central sleep apn...
Illuminating Airway Nerve Structure and Function in Chronic Cough
Illuminating Airway Nerve Structure and Function in Chronic Cough
Airway nerves regulate vital airway functions including bronchoconstriction, cough, and control of respiration. Dysregulat...
Chronic Cough as a Genetic Neurological Disorder? Insights from Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)
Chronic Cough as a Genetic Neurological Disorder? Insights from Cerebellar Ataxia with Neuropathy and Vestibular Areflexia Syndrome (CANVAS)
Chronic cough is common, and in many cases unexplained or refractory to otherwise effective treatment of associated medica...
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis
Gene variants have been identified in patients with familial or sporadic idiopathic pulmonary fibrosis (IPF). These varian...
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis
People living with cystic fibrosis (CF) experience impaired quality of life, but the extent to which pulmonary function is...
Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis: A Pilot Study
Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis: A Pilot Study
Methotrexate (MTX), a folate antagonist, is often used as second-line treatment in patients with sarcoidosis. Effectivenes...
Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening
Lung Cancer in Never Smokers: Delving into Epidemiology, Genomic and Immune Landscape, Prognosis, Treatment, and Screening
Lung cancer in never smokers (LCINS) represents a growing and distinct entity within the broader landscape of lung maligna...
Prognostic Impact of Cancer Inflammation Prognostic Index for Non-small Cell Lung Cancer
Prognostic Impact of Cancer Inflammation Prognostic Index for Non-small Cell Lung Cancer
Cancer-inflammation prognostic index (CIPI) is calculated by multiplying the concentration of carcinoembryonic antigen by ...
Predictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population
Predictive Value of CT Biomarkers in Lung Transplantation Survival: Preliminary Investigation in a Diverse, Underserved, Urban Population
Survival following lung transplant is low. With limited donor lung availability, predicting post-transplant survival is ke...
Assessment and Management of Cough in Idiopathic Pulmonary Fibrosis: A Narrative Review
Assessment and Management of Cough in Idiopathic Pulmonary Fibrosis: A Narrative Review
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal disease with an unknown cause. It is characterize...
Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection
Inhibition of Prostaglandin-Degrading Enzyme 15-PGDH Mitigates Acute Murine Lung Allograft Rejection
Acute rejection is a frequent complication among lung transplant recipients and poses substantial therapeutic challenges. ...
A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension
A Clinical Decision Tool for Risk Stratifying Patients with Systemic Sclerosis-Related Pulmonary Hypertension
We devised a scoring system to identify patients with systemic sclerosis (SSc) at risk for pulmonary hypertension (PH) and...
An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan
An Artificial Intelligence Platform for the Radiologic Diagnosis of Pulmonary Sarcoidosis: An Initial Pilot Study of Chest Computed Tomography Analysis to Distinguish Pulmonary Sarcoidosis from a Negative Lung Cancer Screening Scan
To determine the reliability of an artificial intelligence, deep learning (AI/DL)-based method of chest computer tomograph...
Recurrent Cough in the Elderly: A Forgotten Entity
Recurrent Cough in the Elderly: A Forgotten Entity
Recurrent cough is little researched in adults. We investigated the prevalence, risk factors, and consequences of recurren...
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