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Is a one-size-fits-all '12-month rule appropriate when it comes to the last search date in systematic reviews?
Is a one-size-fits-all '12-month rule appropriate when it comes to the last search date in systematic reviews?
SRs are a recognised research approach for identifying, synthesising and analysing published evidence on topics of interes...
Expanding the measurement of overdiagnosis in the context of disease precursors and risk factors
Expanding the measurement of overdiagnosis in the context of disease precursors and risk factors
Because individual patients weigh benefits and harms differently, it is important to provide quantitative information abou...
Living health technology assessments: how close to living reality?
Living health technology assessments: how close to living reality?
IntroductionHealthcare decision-makers are exploring more responsive, innovative processes in the wake of the COVID-19 pan...
Detection bias in open-label trials of anticancer drugs: a meta-epidemiological study
Detection bias in open-label trials of anticancer drugs: a meta-epidemiological study
are validated by studies that overcome this limitation, it is desirable to establish central reviewers in oncological open...
Piloting a new method to estimate action thresholds in medicine through intuitive weighing
Piloting a new method to estimate action thresholds in medicine through intuitive weighing
IntroductionThe threshold approach in clinical decision-makingWhen confronted with diagnostic uncertainty clinicians will ...
Re-evaluating the role of pilot trials in informing effect and sample size estimates for full-scale trials: a meta-epidemiological study
Re-evaluating the role of pilot trials in informing effect and sample size estimates for full-scale trials: a meta-epidemiological study
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Bias, quality and reporting in health research: differences and tools for appraisal
Bias, quality and reporting in health research: differences and tools for appraisal
Bias is generally defined as a systematic error or deviation from the truth in research results, which leads to underestim...
Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial
Curcumin and proton pump inhibitors for functional dyspepsia: a randomised, double blind controlled trial
IntroductionFunctional dyspepsia is a frequently occurring disorder that can be caused by a variety of factors, with no ev...
Rapid reviews methods series: Guidance on literature search
Rapid reviews methods series: Guidance on literature search
WHAT IS ALREADY KNOWN ON THIS TOPICCompared with systematic reviews, rapid reviews (RR) often abbreviate or limit the lite...
Catalogue of bias: novelty bias
Catalogue of bias: novelty bias
Novelty bias is the tendency for an intervention to appear better when it is new. It is also known as the ‘novel agent eff...
How caring for my child with cancer changed my approach to clinical care and research
How caring for my child with cancer changed my approach to clinical care and research
I am a clinical psychologist who specialises in helping children with medical illnesses and their families. I am also a mo...
Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment
Rapid reviews methods series: Guidance on team considerations, study selection, data extraction and risk of bias assessment
WHAT IS ALREADY KNOWN ON THIS TOPICCompared with full systematic reviews, rapid reviews (RRs) often omit dual processes or...
Relationship between the conflicts of interest and the results of meta-analyses of homoeopathy trials
Relationship between the conflicts of interest and the results of meta-analyses of homoeopathy trials
In the absence of robust trials supporting the efficacy of homoeopathy, people who criticise or, on the contrary, defend h...
Exploring advanced methods for network meta-analysis
Exploring advanced methods for network meta-analysis
High-quality systematic reviews (SRs) of both new and existing health technologies are vital to inform clinical practices ...
What is the place in therapy for nirmatrelvir/ritonavir?
What is the place in therapy for nirmatrelvir/ritonavir?
The COVID-19 pandemic presents substantial challenges for governments and providers keen to provide effective treatments. ...
Metro Mapping: development of an innovative methodology to co-design care paths to support shared decision making in oncology
Metro Mapping: development of an innovative methodology to co-design care paths to support shared decision making in oncology
Shared decision making and service designTreatment decision-making can be complex, notably when there are multiple treatme...
Challenges to delivering evidence-based management for long COVID
Challenges to delivering evidence-based management for long COVID
Early on in the COVID-19 pandemic, scientists forewarned of a potential medium to long-term post-acute sequelae in patient...
Plain language summaries: enhancing patient-centred care and improving accessibility of health research
Plain language summaries: enhancing patient-centred care and improving accessibility of health research
As part of the Open Science movement, plain language summaries (PLSs) could make scientific research more understandable a...
Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives?
Interpreting the results from the first randomised controlled trial of colonoscopy: does it save lives?
In screening for colorectal cancer (CRC), colonoscopy is generally referred to as the ‘gold standard’, as it examines both...
Indias latest essential medicines list: gaps, strengths and opportunities in evidence-based decision-making
Indias latest essential medicines list: gaps, strengths and opportunities in evidence-based decision-making
Essential medicines—defined by the WHO as ‘those that satisfy the priority health care needs of the population’—are meant ...
Smartphone apps for point-of-care information summaries: systematic assessment of the quality and content
Smartphone apps for point-of-care information summaries: systematic assessment of the quality and content
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Decision Analysis in SHared decision making for Thromboprophylaxis during Pregnancy (DASH-TOP): a sequential explanatory mixed-methods pilot study
Decision Analysis in SHared decision making for Thromboprophylaxis during Pregnancy (DASH-TOP): a sequential explanatory mixed-methods pilot study
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Implementing hierarchical network meta-analysis incorporating exchangeable dose effects compared to standard hierarchical network meta-analysis
Implementing hierarchical network meta-analysis incorporating exchangeable dose effects compared to standard hierarchical network meta-analysis
IntroductionNetwork meta-analysis (NMA) compares the efficacy or safety of more than two treatments or treatment doses tha...
Digitally enabled decentralised research: opportunities to improve the efficiency of clinical trials and observational studies
Digitally enabled decentralised research: opportunities to improve the efficiency of clinical trials and observational studies
Data collection for site-centric study approaches can guarantee standardised approaches to measurement. Furthermore, certa...
Mindfulness for academic performance in health professions students: a systematic review
Mindfulness for academic performance in health professions students: a systematic review
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Ten resources for understanding bias in health research: EBM live workshop 2022
Ten resources for understanding bias in health research: EBM live workshop 2022
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Best way not to misuse p values is not to draw definitive conclusions about hypotheses
Best way not to misuse p values is not to draw definitive conclusions about hypotheses
A recent article in BMJ Evidence-Based Medicine asserted the following1, ‘We begin by saying that p values themselves are ...
Proposed triggers for retiring a living systematic review
Proposed triggers for retiring a living systematic review
One LSR investigated the effect of adjuvant tyrosine kinase inhibitors (TKIs) on the risk of cancer recurrence and progres...
Applying the time needed to treat to NICE guidelines on lifestyle interventions
Applying the time needed to treat to NICE guidelines on lifestyle interventions
There is a growing emphasis on interventions where clinicians identify and aim to change unhealthy habits in individuals, ...
Shared decision-making as a method of care
Shared decision-making as a method of care
Care happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover...
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