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Mutation Patterns of Integrase Gene Affect Antiretroviral Resistance in Various non-B Subtypes of Human Immunodeficiency Virus Type-1 and Their Implications for Patients’ Therapy
Although primary integrase strand transfer inhibitor resistance mutations are currently uncommon, the increasing use of in...
Chemical composition, mineral profile, anti-bacterial, and wound healing properties of snail slime of Helix aspersa Müller
Mucus is a substance made by snails that serves a variety of purposes and is increasingly employed in the medical and cosm...
Efficacy of HMJ-38, a new quinazolinone analogue, against the gemcitabine-resistant MIA-PaCa-2 pancreatic cancer cells
Gemcitabine is frequently utilized to treat pancreatic cancer. The purpose of our study was to create a gemcitabine-resist...
Hematological Biomarkers of Troponin, Neutrophil-to-Lymphocyte Ratio, and Monocyte-toLymphocyte Ratio Serve as Effective Predictive Indicators of High-Risk Mortality in Acute
Background: Assessing high-risk mortality in acute coronary syndrome (ACS) patients, encompassing ST-Elevation Myocardial ...
Celastrol restricts experimental periodontitis related alveolar bone loss by suppressing inflammatory cytokine response
Introduction: Periodontitis is a common chronic inflammatory disease characterized by the destruction of the supporting st...
Continuous Intrathecal Saline Infusion for Treating Refractory Spontaneous Intracranial Hypotension: A Case Report
Spontaneous intracranial hypotension (SIH) is a poorly understood condition that presents with a wide variety of symptoms,...
Endometrial Fluid Biomarkers And Their Potential As Predictors Of Successful Embryo Implantation
Background: Embryo implantation is a complex biological process which requires synchronized dialogue between the receptive...
Age-Specific Percentile-based Prostate-Specific Antigen Cutoff Values Predict the Risk of Prostate Cancer: a single hospital observation
Background Testing for prostate-specific antigen (PSA) is often recommended for men with a potential risk of prostate canc...
Evaluation of antibacterial efficacy of Lawsonia inermis Linn (henna) on periodontal pathogens using agar well diffusion and broth microdilution methods: an in-vitro study
Background: Although widely explored in medicine, limited evidence exists in the literature regarding the efficacy of Laws...
Evaluation of SARS-CoV-2 infection risks after primary vaccination with BNT162b2, BBIBP-CorV, or ChAdOx1-nCOV-19 and after homologous and heterologous booster vaccinations with these vaccines and evaluation of SARS-CoV-2 reinfection profiles
Background: The emergence of SARS-CoV-2 variants has significantly increased the number of cases of COVID-19 among vaccina...
Hipoxia modulates the secretion of growth factors in of human umbilical cord-derived mesenchymal stem cells
Background: Mesenchymal stem cell (MSC) has great potential as therapies due its ability to regenerate tissue damage and p...
Combination treatment of pembrolizumab with DC-CIK cell therapy for Advanced hepatocellular carcinoma: a case report
Background: Recently, immunotherapy has emerged as a promising method for advanced HCC treatment. There are several clinic...
Precision Medicine Advancements in Glioblastoma: A Systematic Review
Background. Glioblastoma multiforme, commonly known as GBM or glioblastoma is a grade IV astrocytoma. Brain tumors are dif...
Metformin induces autophagy of cisplatin-resistant human gastric cancer cells in addition to apoptosis
Metformin has been used to treat cases of type 2 diabetes mellitus, and mounting studies have shown that metformin can act...
Effects of Anti-Retroviral Therapy on Baseline Serum Interleukin-18 levels in HIV-I Infected Patients Relative to Viral Suppression and CD4+ Gain: a prospective pilot study
Background: In HIV infection, dysregulation of cytokines, including interleukin 18 (IL-18), has been linked to poor clinic...
Red cell distribution width, neutrophil lymphocyte ratio and interleukin 10 are good prognostic markers in multiple myeloma
Multiple myeloma (MM) is still an incurable disease so we need to continue developing new diagnostic and prognostic option...
Toxicological Evaluation of a Polyherbal Formulation on Testicular Function and Gonadal Histomorphology in Exposed Wistar Rats
Introduction: Dr Iguedo Goko Cleanser® is a herbal formulation (HF) widely marketed in southern Nigeria and purported to b...
Radial arterial waves for chemotherapy- and radiotherapy-related myocardial damage identification in patients with breast cancer
Introduction Chemotherapy and radiation therapy for breast cancer cause side effects, such as cardiovascular changes, whic...
The intensity of free radical processes and chaperone activity in the saliva of patients with type 2 diabetes
Introduction: Saliva is a clinically informative biological fluid that contains many biomarkers, allowing multiple analyse...
Beyond mental stress-induced myocardial ischemia following the COVID-19 vaccine
By Chih-Cheng Lai and Po-Ren Hsueh, Published on 02/22/23
New-onset diabetes in COVID-19: The molecular pathogenesis
Diabetes mellitus (DM) is still a challenging metabolic disease worldwide. In the current situation, the world is facing a...
Effects of Hepatocyte Growth Factor on Porcine Mammary Cell Growth and Senescence
Background: The porcine mammary glands share morphological and physiological similarities with human ones, making primary ...
High levels of Histone H3 K27 acetylation and tri-methylation are associated with shorter survival in Oral Squamous Cell Carcinoma patients
Background: Acetylation and trimethylation of histone H3 lysine 27 (H3K27ac and H3K27me3) generally activate and repress t...
The Impact of Procalcitonin in Assessing Outcomes in Pediatrics Severe Trauma Cases: A Three-Year Experience from a Tertiary Hospital
Background Although procalcitonin levels are raised in patients with systemic inflammation, its usage in pediatric patient...
Jugular Foramen versus Hypoglossal Canal in Axial CT scan
Background: Differentiating jugular foramen from hypoglossal canal in computed tomography (CT) scan is vital for correct d...
A1 adenosine receptor antagonist induces cell apoptosis in KYSE-30 and YM-1 esophageal cancer cell lines
Background and Aim: Adenosine A1 receptor (AA1R) has been shown to have an inhibitory effect on cell growth in several can...
Can multidetector CT scan replace MRI for evaluation of mesorectal fasca in rectal cancer?
Abstract Background Colorectal cancer is the 4th leading cause of cancer mortality. Aim This study aimed to can multidetec...
Is autologous platelet activation the key step in ovarian therapy for fertility recovery and menopause reversal?
Platelets are a uniquely mammalian physiologic feature. As the only non-marine vertebrates to experience menopause, humans...
Crosstalk between Fatty Acid Metabolism and Tumour-Associated Macrophages in Cancer Progression
Over the last few decades, cancer has been regarded as an independent and selfsustaining progression. The earliest hallmar...
Analysis of Antiquorum-Sensing and Antibiofilm Activity by Pomelo Peel Extract (Citrus maxima) on Multidrug-Resistance Pseudomonas aeruginosa
Pseudomonas aeruginosa is gram-negative bacteria with high adaptability by forming biofilms and quorum-sensing mechanisms ...
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