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The protective role of gamma zone peripapillary atrophy in diabetic retinopathy: insights from deep learning and SS-OCT angiography
1 IntroductionDiabetes mellitus is a major public health issue that projected to affect 693 million adults by 2045 (Cho et...
Factors, mechanisms and improvement methods of muscle strength loss
1 IntroductionThe decline in organ function is an inevitable part of aging. The global population aged 65 and older is pro...
Low-input CUT&Tag for efficient epigenomic profiling of zebrafish stage I oocytes
IntroductionEpigenetics, including DNA methylation, histone modification, and non-coding RNA, regulate gene expression by ...
Molecular and metabolomic characterization of hiPSC-derived cardiac fibroblasts transitioning to myofibroblasts
Highlights• Passaging promotes the activation of fibroblasts to myofibroblasts.• TGFβ1 treatment activates the fibroblasts...
Genipin cross-linked gelatin hydrogel for encapsulating wharton jelly mesenchymal stem cells and basic fibroblast growth factor delivery in vocal fold regeneration
Approaches to regenerate vocal fold in glottic insufficiency remains to be a focus for exploration. This is attributed to ...
miR-185-5p regulates the proliferation and differentiation of neural stem/progenitor cells
IntroductionDuring the development of the vertebrate central nervous system (CNS), multipotent neural stem/progenitor cell...
Advances and prospects of precision nanomedicine in personalized tumor theranostics
1 IntroductionTumor, or cancer, is a disease characterized by abnormal proliferation and growth of cells, which can occur ...
Erratum: Embryonic temperature has long-term effects on muscle circRNA expression and somatic growth in Nile tilapia
An erratum on: Rbbani G, Murshed R, Siriyappagouder P, Sharko F, Nedoluzhko A, Joshi R, Galindo-Villegas J, Raeymaekers JA...
Editorial: Proceedings of the 9th international symposium on the biology of vertebrate sex determination 2023
al., 2021). In most mammals, sex determination is genetically dictated, initiated by the expression of the testis-promotin...
Impact of galectin-3 on neurotrophic factor expression by PCR array: potential implications for the human cornea
IntroductionThe cornea is highly innervated, containing a dense network of sensory nerve fibers primarily originating from...
Applications of artificial intelligence in regenerative dentistry: promoting stem cell therapy and the scaffold development
1 IntroductionRecently, AI has grown in a number of ways thanks to developments in needs of computer hardware, software, a...
Paternal impact on the developmental programming of sexual dimorphism
IntroductionSexual dimorphism (SDM) refers to the phenotypic variations between males and females within the same species....
Transcriptional regulation in the absence of inositol trisphosphate receptor calcium signaling
1 IntroductionCalcium is viewed as a vital signaling molecule that regulates many important physiological processes includ...
The role of ferroptosis-related non-coding RNA in liver fibrosis
Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte...
Deciphering hematopoietic stem cell development: key signaling pathways and mechanisms
IntroductionVarious types of blood cells, such as lymphoid and myeloid cells, are produced from hematopoietic stem cells (...
Editorial: Genetic and cellular heterogeneity in tumors
occupying 10%-20% of invasive breast cancer cases, is the subtype with the worst prognosis caused by the absence of target...
T-cadherin modulates adipogenic differentiation in mesenchymal stem cells: insights into ligand interactions
1 IntroductionAdipose tissue, a subtype of connective tissue, encompasses a diverse array of cell types, including stem/pr...
Somatic piRNA and PIWI-mediated post-transcriptional gene regulation in stem cells and disease
PIWI-interacting RNAs (piRNAs) are small non-coding RNAs that bind to the PIWI subclass of the Argonaute protein family an...
An improved method for whole-mount in situ hybridization in regenerating tails of Xenopus laevis tadpoles
1 IntroductionOne of the most frequently used methods in the concept of “seeing is believing” is in situ hybridization, wh...
Progress in the pathogenic mechanism, histological characteristics of hereditary dentine disorders and clinical management strategies
Hereditary dentine disorders are autosomal dominant diseases that affect the development and structure of dentine, leading...
New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy
New insight of the pathogenesis in osteoarthritis: the intricate interplay of ferroptosis and autophagy mediated by mitophagy/chaperone-mediated autophagy
Ferroptosis, characterized by iron accumulation and lipid peroxidation, is a form of iron-driven cell death. Mitophagy is ...
An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations
An optimized protocol for expression and purification of monomeric full-length BAX protein for functional interrogations
Diverse developmental signals and pro-death stresses converge on the regulation of the mitochondrial pathway of apoptosis....
ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells
ACE2 knockout hinders SARS-CoV-2 propagation in iPS cell-derived airway and alveolar epithelial cells
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, continues to spread around ...
Signaling plasticity in the integrated stress response
Signaling plasticity in the integrated stress response
The Integrated Stress Response (ISR) is an essential homeostatic signaling network that controls the cell’s biosynthetic c...
Editorial: Artificial intelligence applications in chronic ocular diseases
Editorial: Artificial intelligence applications in chronic ocular diseases
Editorial: Artificial Intelligence Applications in Chronic Ocular DiseasesYanwu Xu1,2, Weihua Yang31School of Future Techn...
Gene expression in mice with endothelium-specific telomerase knockout
Gene expression in mice with endothelium-specific telomerase knockout
Endothelial cells (EC), lining the vasculature, serve essential functions fundamental for normal physiology of every organ...
Extracellular molecular signals shaping dendrite architecture during brain development
Extracellular molecular signals shaping dendrite architecture during brain development
Proper growth and branching of dendrites are crucial for adequate central nervous system (CNS) functioning. The neuronal d...
Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review
Application and development of hydrogel biomaterials for the treatment of intervertebral disc degeneration: a literature review
Low back pain caused by disc herniation and spinal stenosis imposes an enormous medical burden on society due to its high ...
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
Functional specialization of Aurora kinase homologs during oogenic meiosis in the tunicate Oikopleura dioica
A single Aurora kinase found in non-vertebrate deuterostomes is assumed to represent the ancestor of vertebrate Auroras A/...
Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy
Plasminogen activator inhibitor 1 is associated with high-grade serous ovarian cancer metastasis and is reduced in patients who have received neoadjuvant chemotherapy
Introduction: High-grade serous ovarian cancer (HGSOC) is the most prevalent and deadliest subtype of epithelial ovarian c...
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