Front. Cell Dev. Biol.

Sec. Cancer Cell Biology

Volume 12 - 2024 | doi: 10.3389/fcell.2024.1517401

This article is part of the Research Topic Clinical Advances and Practice of Digestive System Cancer Progression and Metastasis Induced by Immune Factors View all articles

Provisionally accepted

Guozhu Zhang 1 Kejia Wu 2 Xiaobo Jiang 3 YUAN GAO 4 Dong Ding 4 Hao Wang 1 Chongyuan Yu 2 Xiaozhong Wang 5 Naixin Jia 6 Li Zhu 1* 1 Department of Emergency Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China 2 Department of Hepatobiliary and Pancreatic Surgery, Third Affiliated Hospital of Soochow University, Changzhou, China 3 Kunshan Zhenchuan Community Health Service Center, Kunshan, China 4 Department of Hepato-biliary-pancreatic Surgery, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou, China 5 Department of General Surgery, Wujin Affiliated Hospital of Jiangsu University and The Wujin clinical college of Xuzhou Medical University, Changzhou, China 6 Department of Hepatobiliary Surgery, Kunshan First People's Hospital affiliated to jiangsu University, Kunshan, China

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Liver fibrosis represents a reversible pathophysiological process, caused by chronic inflammation stemming from hepatocyte damage. It delineates the initial stage in the progression of chronic liver disease. This pathological progression is characterized by the excessive accumulation of the extracellular matrix (ECM), which leads to significant structural disruption and ultimately impairs liver function. To date, no specific antifibrotic drugs have been developed, and advanced liver fibrosis remains largely incurable. Liver transplantation remains the sole efficacious intervention for advanced liver fibrosis; nevertheless, it is constrained by exorbitant costs and the risk of postoperative immune rejection, underscoring the imperative for novel therapeutic strategies. Ferroptosis, an emergent form of regulated cell death, has been identified as a pivotal regulatory mechanism in the development of liver fibrosis and is intricately linked with the progression of liver diseases. Recent investigations have elucidated that a diverse array of non-coding RNAs (ncRNAs), including microRNAs, long non-coding RNAs, and circular RNAs, are involved in the ferroptosis pathway, thereby modulating the progression of various diseases, including liver fibrosis. In recent years, the roles of ferroptosis and ferroptosis-related ncRNAs in liver fibrosis have attracted escalating scholarly attention. This paper elucidates the pathophysiology of liver fibrosis, explores the mechanisms underlying ferroptosis, and delineates the involvement of ncRNA-mediated ferroptosis pathways in the pathology of liver fibrosis. It aims to propose novel strategies for the prevention and therapeutic intervention of liver fibrosis.

Keywords: liver fibrosis, ferroptosis, miRNA, lncRNA, circRNA

Received: 26 Oct 2024; Accepted: 25 Nov 2024.

Copyright: © 2024 Zhang, Wu, Jiang, GAO, Ding, Wang, Yu, Wang, Jia and Zhu. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

* Correspondence: Li Zhu, Department of Emergency Medicine, Third Affiliated Hospital of Soochow University, Changzhou, China

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