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Systematic review and meta-analysis of randomized controlled trials of ketamine in the treatment of refractory anxiety spectrum disorders
Systematic review and meta-analysis of randomized controlled trials of ketamine in the treatment of refractory anxiety spectrum disorders
Background:Anxiety disorders are common, associated with significant burden of disease, and have high levels of treatment ...
Comparison of psychiatric symptoms between patients with major depression with higher and lower levels of high-sensitivity C-reactive protein in the serum: a preliminary study
Comparison of psychiatric symptoms between patients with major depression with higher and lower levels of high-sensitivity C-reactive protein in the serum: a preliminary study
1. Beurel, E, Toups, M, Nemeroff, CB. The bidirectional relationship of depression and inflammation: double trouble. Neuro...
Transcranial magnetic stimulation for post-traumatic stress disorder
Transcranial magnetic stimulation for post-traumatic stress disorder
Post-traumatic stress disorder (PTSD) is a debilitating psychiatric disorder. While current treatment options are effectiv...
MTORC1 signaling as a biomarker in major depressive disorder and its pharmacological modulation by novel rapid-acting antidepressants
MTORC1 signaling as a biomarker in major depressive disorder and its pharmacological modulation by novel rapid-acting antidepressants
Major depressive disorder (MDD) is a multifactorial psychiatric disorder with obscure pathophysiology. A biomarker-based a...
Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations
Outcomes in treatment-resistant schizophrenia: symptoms, function and clozapine plasma concentrations
Background:Clozapine is the only medication licenced for treating patients with treatment-refractory schizophrenia. Howeve...
CoMET: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine
CoMET: a randomised controlled trial of co-commencement of metformin versus placebo as an adjunctive treatment to attenuate weight gain in patients with schizophrenia newly commenced on clozapine
Background:There is limited evidence on interventions to minimise weight gain at clozapine commencement. We compared the e...
Effect of aripiprazole as an adjunct to atypical antipsychotics on weight and metabolic profile: a 12-week open-label trial
Effect of aripiprazole as an adjunct to atypical antipsychotics on weight and metabolic profile: a 12-week open-label trial
Background:Atypical antipsychotics are widely prescribed, yet have been associated with weight gain and metabolic syndrome...
Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review
Efficacy and safety of lamotrigine in the treatment of bipolar disorder across the lifespan: a systematic review
Background:Bipolar disorder (BD) is a cyclic mood disorder characterised by alternating episodes of mania/hypomania and de...
Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions
Repetitive transcranial magnetic stimulation for major depressive disorder: basic principles and future directions
Repetitive transcranial magnetic stimulation (rTMS) is a safe and well-tolerated intervention for major depressive disorde...
Clozapine discontinuation withdrawal symptoms in schizophrenia
Clozapine discontinuation withdrawal symptoms in schizophrenia
Clozapine is an atypical antipsychotic used in treatment-resistant schizophrenia. Whilst clozapine is highly effective, th...
Asenapine: an atypical antipsychotic with atypical formulations
Asenapine: an atypical antipsychotic with atypical formulations
Asenapine is a second-generation (atypical) antipsychotic medication not available in a pill that can be swallowed; rather...
Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update
Vortioxetine as a new frontier in the treatment of chronic neuropathic pain: a review and update
Chronic neuropathic pain (CNP) is a disabling medical condition that impairs the health-related quality-of-life of affecte...
Successful use of tapering strips for hyperbolic reduction of antidepressant dose: a cohort study
Successful use of tapering strips for hyperbolic reduction of antidepressant dose: a cohort study
Background:Tapering strips facilitate antidepressant discontinuation, allowing for personalised titration of discontinuati...
Prophylactic effects or withdrawal reactions? An analysis of time-to-event data from antidepressant relapse prevention trials submitted to the FDA
Prophylactic effects or withdrawal reactions? An analysis of time-to-event data from antidepressant relapse prevention trials submitted to the FDA
Background:Relapse prevention trials build the scientific foundation for recommendation of antidepressant continuation and...
The role of lumateperone in the treatment of schizophrenia
The role of lumateperone in the treatment of schizophrenia
Schizophrenia is a devastating mental disorder resulting in marked morbidity and mortality despite the optimal use of all ...
Possible pharmacogenetic factors in clozapine treatment failure: a case report
Possible pharmacogenetic factors in clozapine treatment failure: a case report
There is still much to learn about the predictors of therapeutic response in psychiatry, but progress is gradually being m...
Cognitive effects of vortioxetine in older adults: a systematic review
Cognitive effects of vortioxetine in older adults: a systematic review
Many older adults experience a deterioration in cognitive function with aging, and this can have a negative impact on qual...
Effectiveness of 2-year treatment with aripiprazole long-acting injectable and comparison with paliperidone palmitate
Effectiveness of 2-year treatment with aripiprazole long-acting injectable and comparison with paliperidone palmitate
Background:The pragmatic management of psychotic disorders is more complex than that delivered in a controlled trial envir...
Liquorice for pain?
Liquorice for pain?
Liquorice has a long history of use in traditional Chinese, Ayurvedic and herbal medicine. The liquorice plant contains nu...
Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective
Vitamin D in the time of the coronavirus (COVID-19) pandemic – a clinical review from a public health and public mental health perspective
Individuals with serious mental disorders (SMD) may have a higher risk of vitamin D (VIT-D) deficiency. They also experien...
A description of antipsychotic prescribing patterns based on race in the inpatient behavioral health setting
A description of antipsychotic prescribing patterns based on race in the inpatient behavioral health setting
Background and aims:A growing body of research shows that race contributes to disparities in mental health services utiliz...
The effect of non-adherence to antipsychotic treatment on rehospitalization in patients with psychotic disorders
The effect of non-adherence to antipsychotic treatment on rehospitalization in patients with psychotic disorders
Background and Aims:Many patients with psychotic disorders are non-adherent to antipsychotic (AP) medication(s), potential...
Clozapine re-challenge and initiation following neutropenia: a review and case series of 14 patients in a high-secure forensic hospital
Clozapine re-challenge and initiation following neutropenia: a review and case series of 14 patients in a high-secure forensic hospital
Objective:Clozapine remains the most effective intervention for treatment resistant schizophrenia; however, its use is pro...
Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study
Comprehensive assessment of exposure to clozapine in association with side effects among patients with treatment-resistant schizophrenia: a population pharmacokinetic study
Background:There have been scarce data on the distribution of clozapine concentrations in comparison with the recommended ...
Central nervous system-related safety and tolerability of add-on ketamine to antidepressant medication in treatment-resistant depression: focus on the unique safety profile of bipolar depression
Central nervous system-related safety and tolerability of add-on ketamine to antidepressant medication in treatment-resistant depression: focus on the unique safety profile of bipolar depression
Background:There is evidence supporting the use of ketamine in treatment-resistant depression (TRD). However, there are so...
Trends in benzodiazepine receptor agonists use and associated factors in the Belgian general older population: analysis of the Belgian health interview survey data
Trends in benzodiazepine receptor agonists use and associated factors in the Belgian general older population: analysis of the Belgian health interview survey data
Background:Benzodiazepine receptor agonists (BZRA), which include benzodiazepines and z-drugs, are commonly prescribed for...
Prescription attitudes and practices regarding clozapine among Serbian psychiatrists: results of a nationwide survey
Prescription attitudes and practices regarding clozapine among Serbian psychiatrists: results of a nationwide survey
Objective:Despite clozapine being the most effective treatment for treatment-resistant schizophrenia (TRS), a clear explan...
Agomelatine for postpartum depression and breastfeeding
Agomelatine for postpartum depression and breastfeeding
Postpartum depression (PPD) is a common and serious mental health problem that is associated with maternal suffering and n...
Improvement of functional neurological disorder after administration of esketamine nasal spray: a case report
Improvement of functional neurological disorder after administration of esketamine nasal spray: a case report
Functional neurological disorder (FND) is a complex neuropsychiatric condition characterized by the presence of neurologic...
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