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Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
Abundance of the Membrane Proteome in Yeast Cells Lacking Spc1, a Non-catalytic Subunit of the Signal Peptidase Complex
The signal peptidase complex (SPC) mediates processing of signal peptides of secretory precursors. But, recent studies sho...
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs
A Critical Review of Short Antimicrobial Peptides from Scorpion Venoms, Their Physicochemical Attributes, and Potential for the Development of New Drugs
Scorpion venoms have proven to be excellent sources of antimicrobial agents. However, although many of them have been func...
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Sperm-Specific CatSper is Not Conserved in All Vertebrates and May Not be the Only Progesterone-Responsive Ion Channel Present in Sperm
Progesterone (P4) acts as a key conserved signalling molecule in vertebrate reproduction. P4 is especially important for m...
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma
Beyond Hormones: Investigating the Impact of Progesterone Receptor Membrane Component 1 in Lung Adenocarcinoma
Progesterone Receptor Membrane Component 1 (PGRMC1) is a candidate oncogene with a prominent involvement in the pathogenes...
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Aggregation Behavior of Amyloid Beta Peptide Depends Upon the Membrane Lipid Composition
Protein aggregation plays a crucial role in the development of several neurodegenerative diseases. It is important to unde...
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
N-Glycosylation Deficiency in Transgene α7 nAChR and RIC3 Expressing CHO Cells Without NACHO
The human neuronal nicotinic acetylcholine receptor α7 (nAChR) is an important target implicated in diseases like Alz...
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
Sphingomyelin Inhibits Hydrolytic Activity of Heterodimeric PLA2 in Model Myelin Membranes: Pharmacological Relevance
In this work, the heterodimeric phospholipase A2, HDP-2, from viper venom was investigated for its hydrolytic activity in ...
The Role of the Swollen State in Cell Proliferation
The Role of the Swollen State in Cell Proliferation
Cell swelling is known to be involved in various stages of the growth of plant cells and microorganisms but in mammalian c...
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Postsynaptic Density Proteins and Their Role in the Trafficking of Group I Metabotropic Glutamate Receptors
Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system that regulates multiple differe...
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches
G-Protein-Coupled Receptors (GPCRs) make up around 3–4% of the human genome and are the targets of one-third of FDA-...
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
Enhancing Anti-Cancer Immune Response by Acidosis-Sensitive Nanobody Display
One of the main challenges with many cancer immunotherapies is that biomarkers are needed for targeting. These biomarkers ...
Voltage Gated Ion Channels and Sleep
Voltage Gated Ion Channels and Sleep
Ion channels are integral components of the nervous system, playing a pivotal role in shaping membrane potential, neuronal...
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects
Correlation Between Antimicrobial Structural Classes and Membrane Partitioning: Role of Emerging Lipid Packing Defects
In this study, a combination of bioinformatics and molecular dynamics simulations is employed to investigate the partition...
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines
Feasibility Study for the Use of Gene Electrotransfer and Cell Electrofusion as a Single-Step Technique for the Generation of Activated Cancer Cell Vaccines
Cell-based therapies hold great potential for cancer immunotherapy. This approach is based on manipulation of dendritic ce...
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
Evolution of Bioelectric Membrane Potentials: Implications in Cancer Pathogenesis and Therapeutic Strategies
Electrophysiology typically deals with the electrical properties of excitable cells like neurons and muscles. However, all...
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders
Residues of TRPM8 at the Lipid-Water-Interface have Coevolved with Cholesterol Interaction and are Relevant for Diverse Health Disorders
TRPM8 is a non-selective cation channel that is expressed in several tissues and cells and also has a unique property to b...
A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues
A Model for Reversible Electroporation to Deliver Drugs into Diseased Tissues
Drug delivery through electroporation could be highly beneficial for the treatment of different types of diseased tissues ...
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
Effect of Triterpenoids Betulin and Betulinic Acid on Pulmonary Surfactant Membranes
The purpose of this work is to examine how triterpenoids betulin (BE) and betulinic acid (BA) affect the thermotropic phas...
Correction to: Forces and Flows at Cell Surfaces
Correction to: Forces and Flows at Cell Surfaces
I am delighted and honored to introduce the following essay by Dr. Aurelia Honerkamp-Smith, an Assistant Professor in the ...
Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion
Host Lipid Manipulation by Intracellular Bacteria: Moonlighting for Immune Evasion
Lipids are complex organic molecules that fulfill energy demands and sometimes act as signaling molecules. They are mostly...
Track and Field of the Journal of Membrane Biology
Track and Field of the Journal of Membrane Biology
As my 5-year tenure as Editor-in-Chief of the Journal of Membrane Biology reaches the...
Exploration of the Catalytic Cycle Dynamics of Vigna Radiata H+–Translocating Pyrophosphatases Through Hydrogen–Deuterium Exchange Mass Spectrometry
Exploration of the Catalytic Cycle Dynamics of Vigna Radiata H+–Translocating Pyrophosphatases Through Hydrogen–Deuterium Exchange Mass Spectrometry
Vigna radiata H+–translocating pyrophosphatases (VrH+-PPases, EC 3.6.1.1) are present in various endomembranes of pl...
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity
Role of Hydrophobic Amino-Acid Side-Chains in the Narrow Selectivity Filter of the CFTR Chloride Channel Pore in Conductance and Selectivity
Cystic fibrosis is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) anion channel. St...
Forces and Flows at Cell Surfaces
Forces and Flows at Cell Surfaces
Flow is an important physiological signal and modulates a variety of cell functions. However, the molecular mechanisms tha...
The Effect of Benzyl Alcohol on the Voltage-Current Characteristics of Tethered Lipid Bilayers
The Effect of Benzyl Alcohol on the Voltage-Current Characteristics of Tethered Lipid Bilayers
In this study a lipid bilayer membrane model was used in which the bilayer is tethered to a solid substrate with molecular...
Cationic Proteins Rich in Lysine Residue Trigger Formation of Non-bilayer Lipid Phases in Model and Biological Membranes: Biophysical Methods of Study
Cationic Proteins Rich in Lysine Residue Trigger Formation of Non-bilayer Lipid Phases in Model and Biological Membranes: Biophysical Methods of Study
Cationic membrane-active toxins are the most abundant group of proteins in the venom of snakes and insects. Cationic prote...
The Functionality of Membrane-Inserting Proteins and Peptides: Curvature Sensing, Generation, and Pore Formation
The Functionality of Membrane-Inserting Proteins and Peptides: Curvature Sensing, Generation, and Pore Formation
Proteins and peptides with hydrophobic and amphiphilic segments are responsible for many biological functions. The sensing...
Correction: Hans Ussing Memorial Issue: Epithelial Membrane Transport
Correction: Hans Ussing Memorial Issue: Epithelial Membrane Transport
Share this articleAnyone you share the following link with will be able to read this content:Get shareable linkSorry, a sh...
Effect of γ-Oryzanol on the LE–LC Phase Coexistence Region of DPPC Langmuir Monolayer
Effect of γ-Oryzanol on the LE–LC Phase Coexistence Region of DPPC Langmuir Monolayer
We have studied the effect of relative composition of γ-Oryzanol (γ-Or) on the liquid expanded–liquid cond...
Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue
Computational Study on Effect of KCNQ1 P535T Mutation in a Cardiac Ventricular Tissue
Heart diseases such as arrhythmia are the main causes of sudden death. Arrhythmias are typically caused by mutations in sp...
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