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2E‐Decene‐4,6‐diyn‐1‐ol‐acetate inhibits osteoclastogenesis through mitogen‐activated protein kinase‐c‐Fos‐NFATc1 signalling pathways
2E‐Decene‐4,6‐diyn‐1‐ol‐acetate inhibits osteoclastogenesis through mitogen‐activated protein kinase‐c‐Fos‐NFATc1 signalling pathways
Abstract An imbalance of osteoclasts and osteoblasts can result in a variety of bone-related diseases, including osteoporo...
Role of Ang1‐7 in renal haemodynamics and excretion in streptozotocin diabetic rats
Role of Ang1‐7 in renal haemodynamics and excretion in streptozotocin diabetic rats
ABSTRACT Contribution of angiotensin (1-7) (Ang1-7) to control of extrarenal and renal function may be modified in diabete...
Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression
Thymoquinone attenuates isoproterenol‐induced myocardial infarction by inhibiting cytochrome C and matrix metalloproteinase‐9 expression
Abstract Thymoquinone (TQ) is the main active constituent of Nigella sativa. The present study aimed to investigate the ef...
Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative
Evaluation of the systemic and spinal antinociceptive effect of a new hybrid NSAID tetrahydropyran derivative
Abstract Pain is responsible for inducing physical and mental stress, interfering negatively in patients' quality of life....
Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic‐Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats
Pretreatment with Nicotinamide Mononucleotide Increases the Effect of Ischemic‐Postconditioning on Cardioprotection and Mitochondrial Function Following ex vivo Myocardial Reperfusion Injury in Aged Rats
Abstract The present study aims to evaluate the combined effect of ischemic-postconditioning (IPostC) and nicotinamide mon...
Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma
Hsp90 regulates the tumorigenic function of tyrosine protein kinase in osteosarcoma
Abstract Despite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in childr...
PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14–3‐3zeta/Akt signalling pathway
PRDM5 suppresses oesophageal squamous carcinoma cells and modulates 14–3‐3zeta/Akt signalling pathway
Abstract Dysregulation of PR (PRDI-BF1 and RIZ) domain protein 5 (PRDM5) expression has been shown to be associated with t...
Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin‐resistant sodium currents
Prefrontal cortex pyramidal neurons express functional Nav1.8 tetrodotoxin‐resistant sodium currents
Abstract It has been repeatedly proved that Nav1.8 tetrodotoxin (TTX)-resistant sodium currents are expressed in peri...
Cardioprotective effects of Amiodarone in a rat model of epilepsy‐induced cardiac dysfunction
Cardioprotective effects of Amiodarone in a rat model of epilepsy‐induced cardiac dysfunction
Abstract Cardiac dysfunction is one of the leading causes of death in epilepsy. The antiarrhythmic drug amiodarone, is und...
Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Hsp90 regulates the tumorigenic function of TTK in osteosarcoma
Abstract Despite recent advances in diagnosis and treatment, osteosarcoma remains as the most common bone cancer in childr...
Thymoquinone Attenuates Isoproterenol‐Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase‐9 Expression
Thymoquinone Attenuates Isoproterenol‐Induced Myocardial Infarction by 1Inhibiting Cytochrome C and Matrix Metalloproteinase‐9 Expression
Abstract Thymoquinone (TQ) is the main active constituent of Nigella Sativa. The present study aimed to investigate the ef...
Effects of food on the pharmacokinetics of ensartinib in healthy Chinese subjects
Effects of food on the pharmacokinetics of ensartinib in healthy Chinese subjects
Abstract Ensartinib is a promising, aminopyridazine-based small molecule that potently inhibits anaplastic lymphoma kinase...
PRDM5 suppresses esophageal squamous carcinoma cells and modulates 14‐3‐3zeta/Akt signaling pathway
PRDM5 suppresses esophageal squamous carcinoma cells and modulates 14‐3‐3zeta/Akt signaling pathway
Abstract Dysregulation of PR (PRDI-BF1 and RIZ) domain protein 5 (PRDM5) expression has been shown to be associated with t...
Prefrontal cortex pyramidal neurons express functional Nav1.8 TTX‐resistant sodium currents.
Prefrontal cortex pyramidal neurons express functional Nav1.8 TTX‐resistant sodium currents.
Abstract It has been repeatedly proved that Nav1.8 TTX-resistant sodium currents are expressed in peripheral sensory neuro...
2E‐Decene‐4,6‐diyn‐1‐ol‐acetate inhibits osteoclastogenesis through mitogen‐activated protein kinase‐c‐Fos‐NFATc1 signaling pathways
2E‐Decene‐4,6‐diyn‐1‐ol‐acetate inhibits osteoclastogenesis through mitogen‐activated protein kinase‐c‐Fos‐NFATc1 signaling pathways
Abstract An imbalance of osteoclasts and osteoblasts can result in a variety of bone-related diseases, including osteoporo...
Oral immunotherapy in children with a food allergy – where do we stand? ‐ review
Oral immunotherapy in children with a food allergy – where do we stand? ‐ review
Abstract The number of hospitalizations due to an anaphylactic reaction to food is continuously increasing. Therefore, the...
The RNA N6‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer
The RNA N6‐methyladenosine modulator HNRNPA2B1 is involved in the development of non‐small cell lung cancer
ABSTRACT The key N6 methyladenosine (m6A) RNA methylation regulator is associated with multiple tumor progression. However...
Resolvin D1 prevents cadmium chloride‐induced memory loss and hippocampal damage in rats by activation/upregulation of PTEN‐induced suppression of PI3K/Akt/mTOR signaling pathway
Resolvin D1 prevents cadmium chloride‐induced memory loss and hippocampal damage in rats by activation/upregulation of PTEN‐induced suppression of PI3K/Akt/mTOR signaling pathway
Abstract This study evaluated the protective effect of resolvin D1 (RVD1) against cadmium chloride (CdCl2)-induced hippoca...
Electrical modelling of tissue experiments confirms precise locations of resistance and compliance in systemic arterial tree ‐ they are mutually exclusive
Electrical modelling of tissue experiments confirms precise locations of resistance and compliance in systemic arterial tree ‐ they are mutually exclusive
Abstract The study presents electrical modelling of the arterial system to understand the effect of adrenaline on aortae a...
Glucagon‐like peptide‐1 receptor agonist treatment of high carbohydrate intake‐induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and intracellular Ca2+ abnormalities and mitochondrial dysfunction
Glucagon‐like peptide‐1 receptor agonist treatment of high carbohydrate intake‐induced metabolic syndrome provides pleiotropic effects on cardiac dysfunction through alleviations in electrical and intracellular Ca2+ abnormalities and mitochondrial dysfunction
Abstract The pleiotropic effects of glucagon-like peptide-1 receptor (GLP-1R) agonists on the heart have been recognised i...
Evaluation of G2013 (α‐L‐Guluronic Acid) efficacy on PC‐3 cells through inhibiting the expression of inflammatory factors
Evaluation of G2013 (α‐L‐Guluronic Acid) efficacy on PC‐3 cells through inhibiting the expression of inflammatory factors
Abstract Given multiple treatment strategies for prostate cancer, its mortality rate is still high; therefore, novel treat...
Roxadustat (FG‐4592) protects against ischaemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice
Roxadustat (FG‐4592) protects against ischaemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice
Abstract Ischaemia–reperfusion (I/R) is one of the main factors of acute kidney injury (AKI). mitochondrial damage ...
Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations
Allele and genotype frequencies of CYP3A4, CYP3A5, CYP3A7, and GSTP1 gene polymorphisms among mainland Tibetan, Mongolian, Uyghur, and Han Chinese populations
Abstract Over 50% prescribed drugs are metabolized by cytochrome P450 3A (CYP3A) and glutathione S-transferase pi (GSTP1) ...
Intra‐operative and early post‐operative prediction of cardiac surgery‐associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers
Intra‐operative and early post‐operative prediction of cardiac surgery‐associated acute kidney injury: Urinary oxygen tension compared with plasma and urinary biomarkers
Abstract Acute kidney injury (AKI) is a common and serious post-operative complication of cardiac surgery. The value of a ...
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling
Naringin promotes osteogenesis and ameliorates osteoporosis development by targeting JAK2/STAT3 signalling
Abstract Osteoporosis is a systemic bone metabolism disorder, which increases the risk of fractures, and in severe cases i...
Activation of Peripheral Group III Metabotropic Glutamate Receptors Suppressed Formalin‐induced Nociception
Activation of Peripheral Group III Metabotropic Glutamate Receptors Suppressed Formalin‐induced Nociception
Abstract Intraplantar injection of formalin produces persistent spontaneous nociception and hyperalgesia. The underlying m...
Roxadustat (FG‐4592) protects against ischemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice
Roxadustat (FG‐4592) protects against ischemia/reperfusion‐induced acute kidney injury through inhibiting the mitochondrial damage pathway in mice
Abstract Ischemia-reperfusion(I/R)is one of the main factors of acute renal injury (AKI). mitochondrial damage pathway are...
Transcription factor EB enhances autophagy and ameliorates palmitate‐induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells
Transcription factor EB enhances autophagy and ameliorates palmitate‐induced insulin resistance at least partly via upregulating AMPK activity in skeletal muscle cells
Abstract This study aims to elucidate the role of Transcription factor EB (TFEB) in protecting C2C12 myotubes against palm...
Effect of NPC1L1 Polymorphism on Warfarin Stable Dose in Chinese Patients Under Heart Valve Replacement Surgery
Effect of NPC1L1 Polymorphism on Warfarin Stable Dose in Chinese Patients Under Heart Valve Replacement Surgery
Abstract Warfarin is the most often anticoagulant choice for preventable thromboembolism. Notably, vitamin K plays a vital...
The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin‐6 and tumour necrosis factor‐α among post‐menopausal women? A systematic review and meta‐analysis of randomized controlled trials
The efficacy of soy isoflavones combined with soy protein on serum concentration of interleukin‐6 and tumour necrosis factor‐α among post‐menopausal women? A systematic review and meta‐analysis of randomized controlled trials
Abstract The post-menopausal stage in women’s life is associated with the enhancement of inflammation that may be r...
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