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LRP1 in the Vascular Wall
LRP1 in the Vascular Wall
Hemostasis plays a central role in maintaining a normal physiological vasculature, especially during and after vascular in...
Dynamics and Sensitivity of Signaling Pathways
Dynamics and Sensitivity of Signaling Pathways
Signaling pathways serve to communicate information about extracellular conditions into the cell, to both the nucleus and ...
Platelet-Neutrophil Interactions and Thrombo-inflammatory Complications in Type 2 Diabetes Mellitus
Platelet-Neutrophil Interactions and Thrombo-inflammatory Complications in Type 2 Diabetes Mellitus
This review recapitulates the complex pathophysiology of type 2 diabetes mellitus associated with a prothrombotic and proi...
The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature
The Pathobiological Basis for Thrombotic Complications in COVID-19: a Review of the Literature
COVID-19 has rapidly evolved into a global pandemic infecting over two hundred and forty-four million individuals to date....
Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19
Chemokine-Based Therapeutics for the Treatment of Inflammatory and Fibrotic Convergent Pathways in COVID-19
Coronavirus disease 2019 (COVID-19) is an infectious disease caused by the SARS-CoV-2 betacoronavirus and has taken over 7...
The Regulatory Role of miRNAs in Ethanol-induced TLR4 Activation and Neuroinflammation
The Regulatory Role of miRNAs in Ethanol-induced TLR4 Activation and Neuroinflammation
Alcohol is a neurotoxic compound and its abuse can induce brain damage and neurodegeneration. Evidence from the last decad...
Harnessing the Proteostasis Network in Alcohol-associated Liver Disease
Harnessing the Proteostasis Network in Alcohol-associated Liver Disease
Alcohol-associated liver disease (ALD) accounts for significant mortality and morbidity in the USA. Prolonged alcohol expo...
Impact of Alcohol on Bone Health, Homeostasis, and Fracture Repair
Impact of Alcohol on Bone Health, Homeostasis, and Fracture Repair
Alcohol use continues to rise globally. We review the current literature on the effect of alcohol on bone health, homeosta...
Epigenetic Mechanisms Underlying Pathobiology of Alcohol Use Disorder
Epigenetic Mechanisms Underlying Pathobiology of Alcohol Use Disorder
Chronic alcohol use is a worldwide problem with multifaceted consequences including multiplying medical costs and sequelae...
Beyond Growth Factors: Macrophage-Centric Strategies for Angiogenesis
Beyond Growth Factors: Macrophage-Centric Strategies for Angiogenesis
Functional angiogenesis is a critical therapeutic goal in many pathological conditions. Logically, the use of pro-angiogen...
Characterizing Immune Responses in Whole Slide Images of Cancer With Digital Pathology and Pathomics
Characterizing Immune Responses in Whole Slide Images of Cancer With Digital Pathology and Pathomics
Our goal is to show how readily available Pathomics tissue analytics can be used to study tumor immune interactions in can...
Leveraging Computational Modeling to Understand Infectious Diseases
Leveraging Computational Modeling to Understand Infectious Diseases
Computational and mathematical modeling have become a critical part of understanding in-host infectious disease dynamics a...
Acceleration of PDE-Based Biological Simulation Through the Development of Neural Network Metamodels
Acceleration of PDE-Based Biological Simulation Through the Development of Neural Network Metamodels
Partial differential equation (PDE) mathematical models of biological systems are widely used to test hypotheses and infer...
Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options
Alcohol-Induced Neuropathy in Chronic Alcoholism: Causes, Pathophysiology, Diagnosis, and Treatment Options
Alcohol abuse causes a wide range of disorders that affect the nervous system. These include confusion, cerebellar ataxia,...
Angiogenesis in Wound Healing following Pharmacological and Toxicological Exposures
Angiogenesis in Wound Healing following Pharmacological and Toxicological Exposures
Toxicological and pharmacological exposures may accelerate or impede wound healing and tissue repair. These exposures impa...
Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?
Apprehending Ulcerative Colitis Management With Springing Up Therapeutic Approaches: Can Nanotechnology Play a Nascent Role?
Ulcerative colitis (UC) is a chronic inflammatory bowel disorder that causes inflammation in the colon and rectum and can ...
Mathematical Modeling and Simulations for Developing Nanoparticle-Based Cancer Drug Delivery Systems: A Review
Mathematical Modeling and Simulations for Developing Nanoparticle-Based Cancer Drug Delivery Systems: A Review
Nanoparticles are crucial for developing patient-/target-specific drug delivery systems. In recent days, mathematical mode...
Nanomedicine in Cancer Clinics: Are We There Yet?
Nanomedicine in Cancer Clinics: Are We There Yet?
Despite preclinical success of nanomedicine for anticancer activity, the clinical success of the same has been very limite...
Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery
Understanding Physico-chemical Interactions of Dendrimers with Guest Molecules for Efficient Drug and Gene Delivery
Drug and gene deliveries are crucial aspects in biomedical application as they stimulate biological response of the body t...
A Reflection on the Mechanism of the Role of Nanoparticles in Increasing the Efficacy of Anti-tumour Properties of Docetaxel
A Reflection on the Mechanism of the Role of Nanoparticles in Increasing the Efficacy of Anti-tumour Properties of Docetaxel
Docetaxel is an important cancer therapeutic drug that targets microtubules. As a taxane, it has high cytotoxic potential ...
Current Pathobiology Reports
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Toxicology of Nanoparticles in Drug Delivery
Toxicology of Nanoparticles in Drug Delivery
Nanoparticles have revolutionized biomedicine especially in the field of drug delivery due to their intriguing properties ...
Role of Nanoscale Delivery Systems in Tissue Engineering
Role of Nanoscale Delivery Systems in Tissue Engineering
Nanotechnology offers enormous opportunities in regulation of the physical, mechanical, electrical, and biological propert...
Magnetic Nanostructures for Cancer Theranostic Applications
Magnetic Nanostructures for Cancer Theranostic Applications
Cancer is a life-threatening disease and one of the leading causes of death globally. Currently a good number therapeutic ...
The Role of Gold Nanoclusters as Emerging Theranostic Agents for Cancer Management
The Role of Gold Nanoclusters as Emerging Theranostic Agents for Cancer Management
This review focuses on introducing the role of luminescent gold nanoclusters (AuNCs) as promising combinatorial agents for...
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