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Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
Targeting MEK/COX-2 axis improve immunotherapy efficacy in dMMR colorectal cancer with PIK3CA overexpression
PIK3CA mutation or overexpression is associated with immunotherapy resistance in multiple cancer types, but is also parado...
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
OTUB1 accelerates hepatocellular carcinoma by stabilizing RACK1 via its non-canonical ubiquitination
Dysregulated ubiquitination modification occupies a pivotal role in hepatocellular carcinoma (HCC) tumorigenesis and progr...
A novel risk score system based on immune subtypes for identifying optimal mRNA vaccination population in hepatocellular carcinoma
A novel risk score system based on immune subtypes for identifying optimal mRNA vaccination population in hepatocellular carcinoma
Although mRNA vaccines have shown certain clinical benefits in multiple malignancies, their therapeutic efficacies against...
DNA-methylome-derived epigenetic fingerprint as an immunophenotype indicator of durable clinical immunotherapeutic benefits in head and neck squamous cell carcinoma
DNA-methylome-derived epigenetic fingerprint as an immunophenotype indicator of durable clinical immunotherapeutic benefits in head and neck squamous cell carcinoma
Cancer immunotherapy provides durable response and improves survival in a subset of head and neck squamous cell carcinoma ...
Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Microbial metabolite trimethylamine-N-oxide induces intestinal carcinogenesis through inhibiting farnesoid X receptor signaling
Microbial dysbiosis is considered as a hallmark of colorectal cancer (CRC). Trimethylamine-N-oxide (TMAO) as a gut microbi...
Pathological response and tumor stroma immunogenic features predict long-term survival in non-small cell lung cancer after neoadjuvant chemotherapy
Pathological response and tumor stroma immunogenic features predict long-term survival in non-small cell lung cancer after neoadjuvant chemotherapy
Major pathological response (MPR) has become a surrogate endpoint for overall survival (OS) in non-small cell lung cancer ...
Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
Emerging roles of deubiquitinating enzymes in actin cytoskeleton and tumor metastasis
Metastasis accounts for the majority of cancer-related deaths. Actin dynamics and actin-based cell migration and invasion ...
Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
Repaglinide restrains HCC development and progression by targeting FOXO3/lumican/p53 axis
The recent focus on the roles of N-linked glycoproteins in carcinogenesis across various malignancies has prompted our exp...
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
O-GlcNAcylation of TRIM29 and OGT translation forms a feedback loop to promote adaptive response of PDAC cells to glucose deficiency
Glucose not only provides energy for tumor cells, but also provides various biomolecules that are essential for their surv...
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
PIN1 promotes the metastasis of cholangiocarcinoma cells by RACK1-mediated phosphorylation of ANXA2
Cholangiocarcinoma (CCA), a primary hepatobiliary malignancy, is characterized by a poor prognosis and a lack of effective...
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
GDF15 induces chemoresistance to oxaliplatin by forming a reciprocal feedback loop with Nrf2 to maintain redox homeostasis in colorectal cancer
Growth differentiating Factor 15 (GDF15) is linked to several cancers, but its effect on chemoresistance in colorectal can...
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Nilotinib in combination with sunitinib renders MCL-1 for degradation and activates autophagy that overcomes sunitinib resistance in renal cell carcinoma
Sunitinib is a recommended drug for metastatic renal cell carcinoma (RCC). However, the therapeutic potential of sunitinib...
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
The prognostic effect of tumor-associated macrophages in stage I-III colorectal cancer depends on T cell infiltration
Tumor-associated macrophages (TAMs) are associated with unfavorable patient prognosis in many cancer types. However, TAMs ...
The predictive significance of chromobox family members in prostate cancer in humans
The predictive significance of chromobox family members in prostate cancer in humans
The Chromobox (CBX) family proteins are crucial elements of the epigenetic regulatory machinery and play a significant rol...
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
STK3 kinase activation inhibits tumor proliferation through FOXO1-TP53INP1/P21 pathway in esophageal squamous cell carcinoma
Esophageal squamous cell carcinoma (ESCC) is an aggressive disease with a poor prognosis, caused by the inactivation of cr...
CAFs vs. TECs: when blood feuds fuel cancer progression, dissemination and therapeutic resistance
CAFs vs. TECs: when blood feuds fuel cancer progression, dissemination and therapeutic resistance
Neoplastic progression involves complex interactions between cancer cells and the surrounding stromal milieu, fostering mi...
Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Identification of a novel gene signature related to prognosis and metastasis in gastric cancer
Gastric Cancer (GC) presents poor outcome, which is consequence of the high incidence of recurrence and metastasis at earl...
Mapping the immune terrain in lung adenocarcinoma progression: Tfh-like cells in tertiary lymphoid structures
Mapping the immune terrain in lung adenocarcinoma progression: Tfh-like cells in tertiary lymphoid structures
R.S. Herbst, D. Morgensztern, C. Boshoff, The biology and management of non-small cell lung cancer. Nature 553, 446–454 (2...
The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
The development of in vitro organotypic 3D vulvar models to study tumor-stroma interaction and drug efficacy
Vulvar squamous cell carcinoma (VSCC) is a rare disease with a poor prognosis. To date, there’s no proper in vitro m...
TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
TGF-β-p-STAT1-LAIR2 axis has a “self-rescue” role for exhausted CD8+ T cells in hepatocellular carcinoma
TGF-β is related to the function of T cells in the tumor microenvironment. However, the characteristics of TGF-β...
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
Predictive genomic biomarkers of therapeutic effects in renal cell carcinoma
In recent years, there have been great improvements in the therapy of renal cell carcinoma. Nevertheless, the therapeutic ...
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
Targeting TRIM24 promotes neuroblastoma differentiation and decreases tumorigenicity via LSD1/CoREST complex
High-risk neuroblastoma (NB) still has an unfavorable prognosis and inducing NB differentiation is a potential strategy in...
miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
miR-4739 promotes epithelial-mesenchymal transition and angiogenesis in “driver gene-negative” non-small cell lung cancer via activating the Wnt/β-catenin signaling
“Driver gene-negative” non-small cell lung cancer (NSCLC) currently has no approved targeted drug, due to the ...
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
SUMOylation inhibitors activate anti-tumor immunity by reshaping the immune microenvironment in a preclinical model of hepatocellular carcinoma
High levels of heterogeneity and immunosuppression characterize the HCC immune microenvironment (TME). Unfortunately, the ...
Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN
Publisher Correction to: RETRACTED ARTICLE: Human bone marrow-derived mesenchymal stem cell-secreted exosomes overexpressing microRNA-34a ameliorate glioblastoma development via down-regulating MYCN
Department of Neurosurgery, Henan Province People’s Hospital, Zhengzhou University, No. 7, Weiwu Road, Zhengzhou, 450003, ...
HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
HPV16 E6/E7-mediated regulation of PiwiL1 expression induces tumorigenesis in cervical cancer cells
PiwiL1 has been reported to be over-expressed in many cancers. However, the molecular mechanism by which these proteins co...
TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
TIPRL1 and its ATM-dependent phosphorylation promote radiotherapy resistance in head and neck cancer
TIPRL1 (target of rapamycin signaling pathway regulator-like 1) is a known interactor and inhibitor of protein phosphatase...
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
Stiffened tumor microenvironment enhances perineural invasion in breast cancer via integrin signaling
Accumulating studies have shown that tumors are regulated by nerves, and there is abundant nerve infiltration in the tumor...
CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
CHIP promotes CAD ubiquitination and degradation to suppress the proliferation and colony formation of glioblastoma cells
Cancer cells are characterized as the uncontrolled proliferation, which demands high levels of nucleotides that are buildi...
Retraction Note: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling
Retraction Note: IFIT1 modulates the proliferation, migration and invasion of pancreatic cancer cells via Wnt/β-catenin signaling
Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which...
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