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Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury
Interdependent Nuclear Co-Trafficking of ASPP1 and p53 Aggravates Cardiac Ischemia/Reperfusion Injury
OBJECTIVE: ASPP1 (apoptosis stimulating of p53 protein 1) is critical in regulating cell apoptosis as a cofactor of p53 to...
Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency
Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency
BACKGROUND: NOTCH1 pathogenic variants are implicated in multiple types of congenital heart defects including hypoplastic ...
RyR2 Serine-2030 PKA Site Governs Ca2+ Release Termination and Ca2+ Alternans
RyR2 Serine-2030 PKA Site Governs Ca2+ Release Termination and Ca2+ Alternans
Background: PKA (protein kinase A)–mediated phosphorylation of cardiac RyR2 (ryanodine receptor 2) has been extensively st...
Flavonifractor plautii Protects Against Elevated Arterial Stiffness
Flavonifractor plautii Protects Against Elevated Arterial Stiffness
BACKGROUND: Dysbiosis of gut microbiota plays a pivotal role in vascular dysfunction and microbial diversity was reported ...
Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure
Hydrogen Sulfide Modulates Endothelial–Mesenchymal Transition in Heart Failure
BACKGROUND: Hydrogen sulfide is a critical endogenous signaling molecule that exerts protective effects in the setting of ...
NDRG1 Signaling is Essential for Endothelial Inflammation and Vascular Remodeling
NDRG1 Signaling is Essential for Endothelial Inflammation and Vascular Remodeling
BACKGROUND: NDRG-1 (N-myc downstream-regulated gene 1) is a member of NDRG family that plays essential roles in cell diffe...
LLPS of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening
LLPS of DDR1 Counteracts the Hippo Pathway to Orchestrate Arterial Stiffening
BACKGROUND: The Hippo-YAP (yes-associated protein) signaling pathway is modulated in response to various environmental cue...
Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart
Inhibition of Eicosanoid Degradation Mitigates Fibrosis of the Heart
BACKGROUND: Organ fibrosis due to excessive production of extracellular matrix by resident fibroblasts is estimated to con...
Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes
Maintenance of Enteral ACE2 Prevents Diabetic Retinopathy in Type 1 Diabetes
BACKGROUND: We examined components of systemic and intestinal renin-angiotensin system on gut barrier permeability, glucos...
Late-Breaking Basic Science Abstracts From the American Heart Association’s Scientific Sessions 2022
© American Heart Association, Inc. All rights reserved. Unauthorized ...
Fishing Out the Role of RBPMS2 in Cardiac Splicing
Neil C. Chi Correspondence to: Neil C. Chi, MD, PhD, Department of Medicine, Division of Cardiology, University of Califor...
Peering into the Molecular Machinery for Regulation of Cav1.2 Channel Clusters
Peering into the Molecular Machinery for Regulation of Cav1.2 Channel Clusters
Thomas J. Hund Correspondence to: Thomas J. Hund, PhD, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio St...
Prohibiting MG53 Phosphorylation Optimizes its Therapeutic Potential in Diabetes
Prohibiting MG53 Phosphorylation Optimizes its Therapeutic Potential in Diabetes
Long-Sheng Song Correspondence to: Long-Sheng Song, MD, FAHA, FISHR Department of Internal Medicine, Carver College of Med...
Tropoelastin Improves Post-Infarct Cardiac Function by Increasing Scar Elastin
Tropoelastin Improves Post-Infarct Cardiac Function by Increasing Scar Elastin
BACKGROUND: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocyt...
Divergent Actions of Myofibroblast and Myocyte β2-Adrenoceptor in Heart Failure and Fibrotic Remodeling
Yang K. Xiang Correspondence to: Yang K. Xiang. Email E-mail Address: [email protected] https://orcid.org/0000-0003-1786...
TXNIP Suppresses the Osteochondrogenic Switch of VSMCs in Atherosclerosis
TXNIP Suppresses the Osteochondrogenic Switch of VSMCs in Atherosclerosis
BACKGROUND: The osteochondrogenic switch of vascular smooth muscle cells (VSMCs) is a pivotal cellular process in atherosc...
Praliciguat Promotes Ischemic Leg Reperfusion on Leptin Receptor-Deficient Mice
Praliciguat Promotes Ischemic Leg Reperfusion on Leptin Receptor-Deficient Mice
BACKGROUND: Lower-limb peripheral artery disease is one of the major complications of diabetes. Peripheral artery disease ...
Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression
Epsin Nanotherapy Regulates Cholesterol Transport to Fortify Atheroma Regression
BACKGROUND: Excess cholesterol accumulation in lesional macrophages elicits complex responses in atherosclerosis. Epsins, ...
RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function
RBPMS2 Is a Myocardial-Enriched Splicing Regulator Required for Cardiac Function
Background: RBPs (RNA-binding proteins) perform indispensable functions in the post-transcriptional regulation of gene exp...
Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms
Background: Activated macrophages contribute to the pathogenesis of vascular disease. Vein graft failure is a major clinic...
Persisting Platelet Activation and Hyperactivity in COVID-19 Survivors
Persisting Platelet Activation and Hyperactivity in COVID-19 Survivors
Jairo Ramos Temerozo https://orcid.org/0000-0002-8092-2149 Laboratory of Immunopharmacology, Oswaldo Cruz Institute, FIOC...
Correction to: Gut dysbiosis promotes preeclampsia by regulating macrophages and trophoblasts
© American Heart Association, Inc. All rights reserved. Unauthorized ...
In Memoriam Tribute to Jeffrey Robbins, PhD (1950–2022)
In Memoriam Tribute to Jeffrey Robbins, PhD (1950–2022)
Sakthivel Sadayappan Correspondence to: Sakthivel Sadayappan, PhD, MBA, Department of Internal Medicine, Division of Cardi...
PCSK9 Pleiotropism: In the Same Vein as Statins
PCSK9 Pleiotropism: In the Same Vein as Statins
Babak Razani Correspondence to: Babak Razani, MD, PhD, University of Pittsburgh School of Medicine and University of Pitts...
Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification
Nidogen-2 is a Novel Endogenous Ligand of LGR4 to Inhibit Vascular Calcification
BACKGROUND Vascular calcification is closely related to the all-cause mortality of cardiovascular events. Basement membran...
Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation
Spatiotemporal Control of Vascular CaV1.2 by α1C S1928 Phosphorylation
BACKGROUND: L-type CaV1.2 channels undergo cooperative gating to regulate cell function, although mechanisms are unclear. ...
The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans
The Effect of a Neuronal Nitric Oxide Synthase Inhibitor on Neurovascular Regulation in Humans
BACKGROUND: Neurovascular coupling (NVC) is a key process in cerebral blood flow regulation. NVC ensures adequate brain pe...
Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury
Blocking MG53S255 Phosphorylation Protects Diabetic Heart From Ischemic Injury
BACKGROUND: As an integral component of cell membrane repair machinery, MG53 (mitsugumin 53) is important for cardioprotec...
The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis
The FES Gene at the 15q26 Coronary-Artery-Disease Locus Inhibits Atherosclerosis
BACKGROUND: Genome-wide association studies have discovered a link between genetic variants on human chromosome 15q26.1 an...
Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling
Sox17 Deficiency Promotes Pulmonary Arterial Hypertension via HGF/c-Met Signaling
Background: In large-scale genomic studies, Sox17, an endothelial-specific transcription factor, has been suggested as a p...
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