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A 3D culture system for evaluating the combined effects of cisplatin and anti-fibrotic drugs on the growth and invasion of lung cancer cells co-cultured with fibroblasts
A 3D culture system for evaluating the combined effects of cisplatin and anti-fibrotic drugs on the growth and invasion of lung cancer cells co-cultured with fibroblasts
Fibrosis and fibroblast activation usually occur in the tissues surrounding a malignant tumor; therefore, anti-fibrotic dr...
Optimal low-intensity pulsed ultrasound stimulation for promoting anti-inflammatory effects in macrophages
Optimal low-intensity pulsed ultrasound stimulation for promoting anti-inflammatory effects in macrophages
In this paper, we stimulated M1-like macrophages (obtained from U937 cells) with low-intensity pulsed ultrasound (LIPUS) t...
pH/thermal dual-responsive multifunctional drug delivery system for effective photoacoustic imaging-guided tumor chemo/photothermal therapy
pH/thermal dual-responsive multifunctional drug delivery system for effective photoacoustic imaging-guided tumor chemo/photothermal therapy
The development of a combination of chemo/photothermal therapy could overcome the limitations of single-modality therapy a...
Biosafety risk assessment of gold and aluminum nanoparticles in tumor-bearing mice
Biosafety risk assessment of gold and aluminum nanoparticles in tumor-bearing mice
To improve the biosafety of the nanodelivery system, this study developed novel monodisperse spherical aluminum nanopartic...
Surface physical cues mediate the uptake of foreign particles by cancer cells
Surface physical cues mediate the uptake of foreign particles by cancer cells
Cancer phenotypes are often associated with changes in the mechanical states of cells and their microenvironments. Numerou...
Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues
Fibroblast clearance of damaged tissue following laser ablation in engineered microtissues
Although the mechanisms underlying wound healing are largely preserved across wound types, the method of injury can affect...
Memory in repetitive protein–protein interaction series
Memory in repetitive protein–protein interaction series
Interactions between proteins coordinate biological processes in an organism and may impact its responses to changing envi...
Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing
Black phosphorus-enhanced injectable hydrogel for infected soft tissue healing
The misuse of antibiotics makes clinical treatment of soft tissue infection a huge challenge in prosthesis replacement. In...
Tailoring inkjet-printed PEDOT:PSS composition toward green, wearable device fabrication
Tailoring inkjet-printed PEDOT:PSS composition toward green, wearable device fabrication
Inkjet printing remains one of the most cost-efficient techniques for device prototyping and manufacturing, offering consi...
Opto-electromechanical quantification of epithelial barrier function in injured and healthy airway tissues
Opto-electromechanical quantification of epithelial barrier function in injured and healthy airway tissues
The airway epithelium lining the luminal surface of the respiratory tract creates a protective barrier that ensures mainte...
Synergistic prevention and reparative effects of sesquiterpene farnesol in a rabbit model of surgical resection-induced osteoarthritis
Synergistic prevention and reparative effects of sesquiterpene farnesol in a rabbit model of surgical resection-induced osteoarthritis
Articular cartilage may regenerate poorly after injury or during aging. In vitro, farnesol can modulate extracellular matr...
Injectable heat-sensitive nanocomposite hydrogel for regulating gene expression in the treatment of alcohol-induced osteonecrosis of the femoral head
Injectable heat-sensitive nanocomposite hydrogel for regulating gene expression in the treatment of alcohol-induced osteonecrosis of the femoral head
For repairing lesions, it is important to recover physiological and cellular activities. Gene therapy can restore these ac...
Mechanosensitive miR-99b mediates the regulatory effect of matrix stiffness on bone marrow mesenchymal stem cell fate both in vitro and in vivo
Mechanosensitive miR-99b mediates the regulatory effect of matrix stiffness on bone marrow mesenchymal stem cell fate both in vitro and in vivo
Mechanical signals from extracellular matrix stiffness are important cues that regulate the proliferation and differentiat...
Highly stretchable and sensitive silicone composites with positive piezoconductivity using nickel powder and ionic liquid
Highly stretchable and sensitive silicone composites with positive piezoconductivity using nickel powder and ionic liquid
Conductive rubber composites are mixtures of stretchable rubber and conductive materials. They can achieve conductivity an...
Skin wound healing improvement in diabetic mice through FTIR microspectroscopy after implanting pluripotent stem cells
Skin wound healing improvement in diabetic mice through FTIR microspectroscopy after implanting pluripotent stem cells
Diabetes is a chronic degenerative disease that carries multiple complications. One of the most important complications is...
Extended preconditioning on soft matrices directs human mesenchymal stem cell fate via YAP transcriptional activity and chromatin organization
Extended preconditioning on soft matrices directs human mesenchymal stem cell fate via YAP transcriptional activity and chromatin organization
Dynamic extracellular matrix (ECM) mechanics plays a crucial role in tissue development and disease progression through re...
Nanosized drug delivery strategies in osteosarcoma chemotherapy
Nanosized drug delivery strategies in osteosarcoma chemotherapy
Despite recent developments worldwide in the therapeutic care of osteosarcoma (OS), the ongoing challenges in overcoming l...
Model of collective detachment in high-grade serous ovarian cancer demonstrates that tumor spheroids produce ECM to support metastatic processes
Model of collective detachment in high-grade serous ovarian cancer demonstrates that tumor spheroids produce ECM to support metastatic processes
High-grade serous ovarian cancer (HGSOC) metastasizes through transcoelomic spread, with both single cells and spheroids o...
Gut-on-a-chip models for dissecting the gut microbiology and physiology
Gut-on-a-chip models for dissecting the gut microbiology and physiology
Microfluidic technologies have been extensively investigated in recent years for developing organ-on-a-chip-devices as rob...
Cardiovascular patient-specific modeling: Where are we now and what does the future look like?
Cardiovascular patient-specific modeling: Where are we now and what does the future look like?
THE RISE OF PATIENT-SPECIFIC COMPUTATIONAL MODELS: FROM 3D RECONSTRUCTIONS TO DIGITAL TWINSSection:ChooseTop of pageTHE RI...
Implantable biorobotic organs
Implantable biorobotic organs
INTRODUCTIONSection:ChooseTop of pageINTRODUCTION <<TECHNICAL CHALLENGES FOR ...CONCLUSIONS AND PERSPECTI...A few ye...
Molecular wayfinding: Mapping transport dynamics
Molecular wayfinding: Mapping transport dynamics
In a world where online shopping and same-day delivery are now the norm, smart freight, transportation, and logistics are ...
Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts
Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts
The myocardium is a mechanically active tissue typified by anisotropy of the resident cells [cardiomyocytes (CMs) and card...
Mechanobiology of the cell nucleus
Mechanobiology of the cell nucleus
Nuclear mechanobiology plays key roles in regulating cell responses1–31. A. Kumar, J. K. Placone, and A....
Biomaterials for enhanced immunotherapy
Biomaterials for enhanced immunotherapy
Cancer immunotherapies have revolutionized the treatment of numerous cancers, with exciting results often superior to conv...
Interacting with tumor cells weakens the intrinsic clockwise chirality of endothelial cells
Interacting with tumor cells weakens the intrinsic clockwise chirality of endothelial cells
Endothelial cells (ECs) possess a strong intrinsic clockwise (CW, or rightward) chirality under normal conditions. Enervat...
Advances in imaging and treatment of atherosclerosis based on organic nanoparticles
Advances in imaging and treatment of atherosclerosis based on organic nanoparticles
Atherosclerosis, a systemic chronic inflammatory disease, can lead to thrombosis and vascular occlusion, thereby inducing ...
Long-acting acid-sensitive ketal-linked dexamethasone microcrystals for treating experimental autoimmune uveitis
Long-acting acid-sensitive ketal-linked dexamethasone microcrystals for treating experimental autoimmune uveitis
Corticosteroids have for some time been used as first-line drugs for the topical treatment of noninfectious uveitis, but p...
Thermosensitive hydrogel carrying extracellular vesicles from adipose-derived stem cells promotes peripheral nerve regeneration after microsurgical repair
Thermosensitive hydrogel carrying extracellular vesicles from adipose-derived stem cells promotes peripheral nerve regeneration after microsurgical repair
Peripheral nerve injuries are commonly occurring traumas of the extremities; functional recovery is hindered by slow nerve...
Engineered matrix microenvironments reveal the heterogeneity of liver sinusoidal endothelial cell phenotypic responses
Engineered matrix microenvironments reveal the heterogeneity of liver sinusoidal endothelial cell phenotypic responses
Fibrosis is one of the hallmarks of chronic liver disease and is associated with aberrant wound healing. Changes in the co...
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