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Real-world data on direct oral anticoagulants in BCR::ABL1-negative myeloproliferative neoplasms (MPNs): a multicenter retrospective study on behalf of scientific subcommittee on MPNs for Turkish society of hematology
Real-world data on direct oral anticoagulants in BCR::ABL1-negative myeloproliferative neoplasms (MPNs): a multicenter retrospective study on behalf of scientific subcommittee on MPNs for Turkish society of hematology
BCR::ABL1-negative myeloproliferative neoplasms (MPNs) pose a substantial risk of thrombosis, leading to significant morbi...
Incidence and risk factors for venous thromboembolism in gynecological cancer: the GOTIC-VTE trial
Incidence and risk factors for venous thromboembolism in gynecological cancer: the GOTIC-VTE trial
Real-world data on venous thromboembolism (VTE) in Japanese patients with gynecological cancer are lacking. The GOTIC-VTE ...
The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease
The foundation for investigating factor XI as a target for inhibition in human cardiovascular disease
Anticoagulant therapy is a mainstay in the management of patients with cardiovascular disease and related conditions chara...
Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors
Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors
Factor XIIa (FXIIa) is a plasma serine protease within the contact activation pathway. Inhibiting FXIIa could offer a viab...
The factor XI/XIa antibody abelacimab combined with enoxaparin inhibits filter clotting in hemodialysis circuits ex vivo
The factor XI/XIa antibody abelacimab combined with enoxaparin inhibits filter clotting in hemodialysis circuits ex vivo
Drugs targeting factor XI may offer an alternative to heparin for preventing blood clotting in extracorporeal circulation....
Heparin-like effect of a dual antiplatelet and anticoagulant (APAC) agent on red blood cell deformability and aggregation in an experimental model
Heparin-like effect of a dual antiplatelet and anticoagulant (APAC) agent on red blood cell deformability and aggregation in an experimental model
Treatments with different antithrombotic agents can affect micro-rheological variables, such as red blood cell (RBC) defor...
Factor XI: structure, function and therapeutic inhibition
Factor XI: structure, function and therapeutic inhibition
Arterial and venous thromboembolism is a major medical concern that requires therapeutic anticoagulation in various medica...
RNAi targeting LMAN1-MCFD2 complex promotes anticoagulation in mice
RNAi targeting LMAN1-MCFD2 complex promotes anticoagulation in mice
Combined deficiency of coagulation factor V (FV) and factor VIII (FVIII) is a rare bleeding disease caused by variants in ...
Evaluation of unfractionated heparin therapy for venous thromboembolism using adjusted body weight in elderly or higher weight patients
Evaluation of unfractionated heparin therapy for venous thromboembolism using adjusted body weight in elderly or higher weight patients
The use of weight-based unfractionated heparin (UFH) infusions is the standard of care in hospital management of venous th...
Assessment of anticoagulant safety and coagulation analysis in mice using the VETSCAN® VSpro analyzer
Assessment of anticoagulant safety and coagulation analysis in mice using the VETSCAN® VSpro analyzer
Animal models of thrombosis play a critical role in research, helping us understand the mechanisms of hemostasis and throm...
Exploring the causal inference of inflammatory bowel disease and ischemic stroke: a bidirectional two-sample Mendelian randomization study
Exploring the causal inference of inflammatory bowel disease and ischemic stroke: a bidirectional two-sample Mendelian randomization study
Growing evidence suggests inflammatory bowel disease (IBD) is linked to ischemic stroke (IS); however, the results are inc...
The association of tumor-expressed REG4, SPINK4 and alpha-1 antitrypsin with cancer-associated thrombosis in colorectal cancer
The association of tumor-expressed REG4, SPINK4 and alpha-1 antitrypsin with cancer-associated thrombosis in colorectal cancer
Novel biomarkers are needed to improve current imperfect risk prediction models for cancer-associated thrombosis (CAT). We...
Early assessment of the pharmacokinetic and pharmacodynamic effects following acetylsalicylic acid loading: toward a definition for acute therapeutic response
Early assessment of the pharmacokinetic and pharmacodynamic effects following acetylsalicylic acid loading: toward a definition for acute therapeutic response
Despite decades of investigations, the optimal assessment of the “therapeutic response” to early after loading...
Prevalence of portal vein thrombosis in non-alcoholic fatty liver disease: a meta-analysis of observational studies
Prevalence of portal vein thrombosis in non-alcoholic fatty liver disease: a meta-analysis of observational studies
Portal vein thrombosis (PVT) is a common complication of cirrhosis as a result of portal hypertension and modification in ...
Real-world effectiveness and safety of evolocumab in very high-risk atherosclerotic cardiovascular disease patients with acute ischemic stroke
Real-world effectiveness and safety of evolocumab in very high-risk atherosclerotic cardiovascular disease patients with acute ischemic stroke
We investigated evolocumab’s real-world effectiveness and safety on a background of statin therapy in the acute phas...
Association between aortic thrombi detected using non-obstructive general angioscopy and atrial fibrillation
Association between aortic thrombi detected using non-obstructive general angioscopy and atrial fibrillation
Atrial fibrillation (AF) is an independent risk factor for stroke and systemic embolism. Cardiogenic and aortogenic emboli...
Incidence and risk factors of venous thromboembolism in kidney transplantation patients: a prospective cohort study
Incidence and risk factors of venous thromboembolism in kidney transplantation patients: a prospective cohort study
To investigate the incidence and explore the risk factors of venous thromboembolism (VTE) within 6 months after k...
EML4-ALK fusion protein in Lung cancer cells enhances venous thrombogenicity through the pERK1/2-AP-1-tissue factor axis
EML4-ALK fusion protein in Lung cancer cells enhances venous thrombogenicity through the pERK1/2-AP-1-tissue factor axis
Accumulating evidence links the echinoderm microtubule-associated protein-like 4 (EML4)-anaplastic lymphoma kinase (ALK) r...
Rural-urban differences in pulmonary embolism mortality by race-ethnicity and sex in the United States, 1999–2020
Rural-urban differences in pulmonary embolism mortality by race-ethnicity and sex in the United States, 1999–2020
Introduction: Racial and ethnic differences in pulmonary embolism (PE) mortality within rural and urban regions in the U.S...
HMG-CoA reductase inhibitors and the attenuation of risk for disseminated intravascular coagulation in patients with sepsis
HMG-CoA reductase inhibitors and the attenuation of risk for disseminated intravascular coagulation in patients with sepsis
Disseminated Intravascular Coagulation (DIC) is a syndrome of dysregulated coagulation. Patients with sepsis are at increa...
Estimated glomerular filtration rate and the risk of stroke in individuals with diabetes mellitus and atrial fibrillation insight from a large contemporary population study
Estimated glomerular filtration rate and the risk of stroke in individuals with diabetes mellitus and atrial fibrillation insight from a large contemporary population study
Diabetes mellitus (DM) is associated with increased risk of embolic complications in non-valvular atrial fibrillation (NVA...
The effects of tranexamic acid on platelets in patients undergoing cardiac surgery: a systematic review and meta-analysis
The effects of tranexamic acid on platelets in patients undergoing cardiac surgery: a systematic review and meta-analysis
This meta-analysis was designed to evaluate the effects of tranexamic acid (TXA) on platelets in patients undergoing cardi...
Reduced fibrin clot permeability on admission and elevated E-selectin at 3 months as novel risk factors of residual pulmonary vascular obstruction in patients with acute pulmonary embolism
Reduced fibrin clot permeability on admission and elevated E-selectin at 3 months as novel risk factors of residual pulmonary vascular obstruction in patients with acute pulmonary embolism
Residual pulmonary vascular obstruction (RPVO) is common following pulmonary embolism (PE) but its association with fibrin...
Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry
Incidence and predictors of post-thrombotic syndrome in patients with proximal DVT in a real-world setting: findings from the GARFIELD-VTE registry
Although substantial progress has been made in the pathophysiology and management of the post-thrombotic syndrome (PTS), s...
Characterization of direct oral anticoagulants use in adult hematopoietic stem cell transplant recipients
Characterization of direct oral anticoagulants use in adult hematopoietic stem cell transplant recipients
Direct oral anticoagulants (DOACs) for venous thromboembolism (VTE) treatment are of interest in oncology due to ease of a...
Mesoglycan for the secondary prevention of superficial vein thrombosis: a randomized, controlled, double-blind study (METRO Study)—rationale and protocol
Mesoglycan for the secondary prevention of superficial vein thrombosis: a randomized, controlled, double-blind study (METRO Study)—rationale and protocol
No data is available about pharmacological secondary prevention of superficial vein thrombosis (SVT) despite 10–15% ...
Characterization of an andexanet alfa administration protocol guided by drug-specific quantitative anti-Xa assays
Characterization of an andexanet alfa administration protocol guided by drug-specific quantitative anti-Xa assays
Following FDA approval in 2018, consensus guidelines recommend andexanet alfa as first-line therapy for the management of ...
The calcium-clot connection: investigating the association between primary hyperparathyroidism and acute venous thromboembolism
The calcium-clot connection: investigating the association between primary hyperparathyroidism and acute venous thromboembolism
Primary hyperthyroidism (PHPT) is a relatively uncommon disease and leads to increased calcium levels. Ionized calcium, kn...
Possible effect of the early administration of tranexamic acid on myocardial injury in patients with severe trauma
Possible effect of the early administration of tranexamic acid on myocardial injury in patients with severe trauma
Hemodynamic stabilization plays a crucial role in the treatment of patients suffering from severe trauma. Current guidelin...
In-Hospital and readmission outcomes of patients with myeloproliferative neoplasms and atrial fibrillation: insights from the National Readmissions Database
In-Hospital and readmission outcomes of patients with myeloproliferative neoplasms and atrial fibrillation: insights from the National Readmissions Database
Patients with myeloproliferative neoplasms (MPNs) and atrial fibrillation (AF) are at increased risk of thrombosis and ble...
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