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CD4 T cell–activating neoantigens enhance personalized cancer vaccine efficacy
Mice and study approval. Five- to 6-week-old male C57BL/6 mice were purchased from The Jackson Laboratory and were allowe...
Vaccines based on the fusion protein consensus sequence protect Syrian hamsters from Nipah virus infection
Research ArticleVaccinesVirology Open Access | 10.1172/jci.insight.175461 Mingqing Lu,1,2 Y...
Diabetes-associated breast cancer is molecularly distinct and shows a DNA damage repair deficiency
Research ArticleMetabolismOncology Open Access | 10.1172/jci.insight.170105 Gatikrushna Panigra...
Intestinal transit-amplifying cells require METTL3 for growth factor signaling and cell survival
Research ArticleGastroenterology Open Access | 10.1172/jci.insight.171657 Charles H. Danan,1,2,...
Single-cell transcriptomics reveals variations in monocytes and Tregs between gout flare and remission
Single-cell transcriptome profiling of peripheral blood mononuclear cells (PBMCs) from gout flare and remission. Peripher...
A CD6-targeted antibody-drug conjugate as a potential therapy for T cell–mediated disorders
Research Article Open Access | 10.1172/jci.insight.172914 Lingjun Zhang,1 Liping Luo,1 ...
Validation of a murine proteome-wide phage display library for identification of autoantibody specificities
Technical AdvanceImmunology Open Access | 10.1172/jci.insight.174976 Elze Rackaityte,1 Irin...
Synergistic roles of DYRK1A and GATA1 in trisomy 21 megakaryopoiesis
DYRK1A is overexpressed in human T21 cells. To assess the role of DYRK1A in the pathogenesis of ML-DS arising from fetal ...
Gut mucosal cells transfer α-synuclein to the vagus nerve
Mice. Mice expressing EGFP in CCK cells [Tg(Cck-EGFP)BJ203Gsat/Mmmh], referred to as Cck-eGFP, were obtained from Mutant ...
Intratumoral aluminum hydroxide–anchored IL-12 drives potent antitumor activity by remodeling the tumor microenvironment
IL-12-ABP protein forms a stable complex with Alhydrogel and maintains activity. ANK-101 is composed of a single-chain hu...
Single-cell transcriptomics analysis of proliferative diabetic retinopathy fibrovascular membranes reveals AEBP1 as fibrogenesis modulator
Cell cluster identification. Human fibrovascular membranes from patients with PDR were collected to profile the cell popu...
In vivo distribution of cerebrospinal fluid tracer in human upper spinal cord and brain stem
The main findings of this study are that a CSF tracer administered at the lumbar level enriched the entire parenchyma of ...
Signaling metabolite succinylacetone activates HIF-1α and promotes angiogenesis in GSTZ1-deficient hepatocellular carcinoma
Cell culture. The human hepatoma cell line HepG2 (ATCC) and HAOECs (ATCC; PCS-100-011) were obtained. Huh7 cells and HUVE...
Human HLA-DR+CD27+ regulatory T cells show enhanced antigen-specific suppressive function
Research ArticleImmunologyTransplantation Open Access | 10.1172/jci.insight.162978 Xiaoqian Ma,...
Localized T3 production modifies the transcriptome and promotes the hepatocyte-like lineage in iPSC-derived hepatic organoids
In humans, the organization of the endoderm and posterior foregut (PFG) occurs during the first 2–3 weeks (E7–E8.5 in mic...
Pediatric HIV+ Kaposi sarcoma exhibits clinical, virological, and molecular features different from the adult disease
Clinical MedicineAIDS/HIVOncology Open Access | 10.1172/jci.insight.167854 Carolina Caro-Vegas,...
Heterogeneous cardiac sympathetic innervation gradients promote arrhythmogenesis in murine dilated cardiomyopathy
Research ArticleCardiology Open Access | 10.1172/jci.insight.157956 Al-Hassan J. Dajani,1 M...
Failure to breathe persists without air hunger or alarm following amygdala seizures
Research ArticleNeuroscience Open Access | 10.1172/jci.insight.172423 Gail I.S. Harmata,1,2,3,4...
Biallelic MAD2L1BP (p31comet) mutation is associated with mosaic aneuploidy and juvenile granulosa cell tumors
Research ArticleGeneticsOncology Open Access | 10.1172/jci.insight.170079 Ghada M. H. Abdel-Sal...
Homeostatic cytokines reciprocally modulate the emergence of prenatal effector PLZF+CD4+ T cells in humans
Cell isolation. PBMCs from adult blood were isolated by Ficoll-Histopaque (MilliporeSigma) gradient centrifugation and cr...
Effects of dulaglutide on alcohol consumption during smoking cessation
The main finding of the present study is that participants treated for smoking cessation drink significantly less alcohol...
Anti–NF-κB peptide derived from nuclear acidic protein attenuates ovariectomy-induced osteoporosis in mice
Research ArticleBone biology Open Access | 10.1172/jci.insight.171962 Kenji Takami,1,2 Kazu...
Incretin effect determines glucose trajectory and insulin sensitivity in youths with obesity
Research ArticleEndocrinologyMetabolism Open Access | 10.1172/jci.insight.165709 Alfonso Galder...
Dormant tumors circumvent tumor-specific adaptive immunity by establishing a Treg-dominated niche via DKK3
D2.1 dormancy is immune independent. The D2 series of cells, consisting of D2A1, D2.OR, and D2.1 cell lines that arose fr...
Quisinostat is a brain-penetrant radiosensitizer in glioblastoma
Cytotoxicity and induction of stable global hyperacetylation in patient-derived GSCs treated with QST. QST (JNJ-26481585)...
N6-methyladenosine–mediated overexpression of long noncoding RNA ADAMTS9-AS2 triggers neuroblastoma differentiation via regulating LIN28B/let-7/MYCN signaling
ADAMTS9-AS2 is differentially expressed in neuroblastoma and is positively correlated with differentiation. We used high-...
Cell-based screen identifies porphyrins as FGFR3 activity inhibitors with therapeutic potential for achondroplasia and cancer
A cell-based receptor/adaptor translocation assay to specifically monitor FGFR3 activity. Plant extracts have long been r...
Endothelial transcriptomic analysis identifies biomarkers of severe and cerebral malaria
Research ArticleInfectious disease Open Access | 10.1172/jci.insight.172845 Cláudia Gomes,1 ...
Smooth muscle–derived adventitial progenitor cells direct atherosclerotic plaque composition complexity in a Klf4-dependent manner
Research ArticleStem cellsVascular biology Open Access | 10.1172/jci.insight.174639 Allison M. ...
Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease
Increased synaptosomal Aβ42 in patients with aMCI. To determine whether brain Aβ load differentiates preclinical AD from ...
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