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Ethics of COVID-19 vaccine trials in rapidly changing contexts
In my recent commentary on the ethics of COVID-19 vaccine trials I argued that the time has come to no longer allow new pl...
Placebo-controlled trials with COVID-19 vaccines: participants first
Key wordsIn the last few months, several commentators have addressed what they believe should be the correct approach with...
An emulated target trial analysis based on Medicare data suggested non-inferiority of Dabigatran versus Rivaroxaban
Objectives : Rivaroxaban and Dabigatran were the first two non-vitamin K antagonist oral anticoagulants ...
Systematic review automation tools improve efficiency but lack of knowledge impedes their adoption: a survey.
Objective We investigated systematic review automation tool use by systematic reviewers, health tech...
Pilot and feasibility studies for pragmatic trials have unique considerations and areas of uncertainty
Defining feasibility and pilot studies in preparation for randomised controlled trials: development of a conceptual framew...
Reducing bias in trials due to reactions to measurement: experts produced recommendations informed by evidence
Objective This study (MEasurement Reactions In Trials) aimed to produce recommendations on how best ...
Abstracts for reports of randomised trials of COVID-19 interventions had low quality and high spin
1. IntroductionIn December 2019, a novel RNA coronavirus, which was subsequently named severe acute respiratory syndrome c...
Consistency of ranking was evaluated as new measure for prediction model stability: longitudinal cohort study
Health e-Research Centre, School of Health Sciences, Faculty of Biology, Medicine and Health, the University of Manchester...
Quality of clinical practice guidelines in Japan remains low: a cross-sectional meta-epidemiological study
Department of Internal Medicine, Kyoto Min-Iren Asukai Hospital, Tanaka Asukai-cho 89, Sakyo-ku, Kyoto, 606-8226, JapanDep...
Evidence of spin in systematic reviews of interventions from the top 5 general medical journals: Overview of reviews
Objective To evaluate the presence of spin in SRs of interventions from the top-5 general medical jo...
Reporting of prognostic clinical prediction models based on machine learning methods in oncology needs to be improved
Centre for Statistics in Medicine, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, Univers...
Cluster randomised trials of individual-level interventions were at high risk of bias
 Broad assessment of risk of biasOverall, all but three of the trials were assessed as at high risk of bias and only one w...
High prevalence of spin was found in pharmacovigilance studies usingdisproportionality analyses todetectsafetysignals: a meta-epidemiologicalstudy
Pharmacovigilance Unit, Grenoble Alpes University Hospital, F-38000 Grenoble, FranceHP2 Laboratory, INSERM U1042, Univ. Gr...
More Consideration is Needed for Retracted Non-Cochrane Systematic Reviews in Medicine: A Systematic Review
Evidence-based Medicine Center, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, ChinaLanzhou Univers...
Prespecification of subgroup analyses and examination of treatment-subgroup interactions in cancer individual participant data meta-analyses are suboptimal
Veroniki AA Straus SE Soobiah C Elliott MJ Tricco AC. A scoping review of indirect comparison methods and applications usi...
The possible effects of iron loss from bloodletting on mortality from pneumonia in the nineteenth century
Patients with phlebotomyEnrico Acerbi (1785-1827)1Pre-1820Milan, Maggiore HospitalAll bAll indicates both uncomplicated an...
An economic valuation technique identified different inpatient care experience as priorities for older Canadians than a traditional approach
Objectives To a) estimate the relative value of older adults’ healthcare experiences based on the Ca...
“Evidence-based Checklists” for Identifying Predatory Journals have Not Been Assessed for Reliability or Validity: An Analysis and Proposal for Moving Forward
PhD Graduate, Department of Health Research Methods, Evidence, and Impact, Faculty of Health Sciences, McMaster University...
Large-scale validation of the Prediction model Risk Of Bias ASsessment Tool (PROBAST) using a short form: high risk of bias models show poorer discrimination
Moons KG Royston P Vergouwe Y Grobbee DE Altman DG. Prognosis and prognostic research: what, why, and how?.BMJ. 2009; 338:...
Favouring Imperfect Awareness over Perfect Ignorance
We welcome Knight & Cook insightful comment on our review. 1 Incomparability of trea...
Using a stepwise approach to simultaneously develop and validate Machine Learning based prediction models
Accurate diagnosis of a disease is essential in healthcare. Prediction models, based on classical regressi...
Informing the Evidence to Decision Process with Health Equity Considerations: Demonstration from the Canadian Rheumatoid Arthritis Care Context
What is New?-We provide a demonstration of how to systematically address health equity considerations in rheumatology thro...
Per protocol analyses produced larger treatment effect sizes than intention to treat: a meta-epidemiological study
Schulz KF Altman DG Moher D CONSORT 2010 Statement: updated guidelines for reporting parallel group randomised trials.BMJ....
The prevalence of HR-HPV infection based on self-sampling among women in China exhibited some unique epidemiologic features
Department of Gynecology and Obstetrics, Peking University Shenzhen Hospital, Shenzhen, ChinaShenzhen Key Laboratory on Te...
ADL-dependent older adults were identified in medico-administrative databases
DRUGS-SAFE National Platform of Pharmacoepidemiology, Bordeaux, FranceUniv. Bordeaux, Inserm UMR 1219, Bordeaux Population...
Imputing intracluster correlation coefficients from a posterior predictive distribution is a feasible method of dealing with unit of analysis errors in a meta-analysis of cluster RCTs
Design and analysis of cluster randomization trials in health research. John Wiley & Sons, Eldridge SM Ashby D...
Risk of bias assessments in systematic reviews and meta-analyses of behavioral interventions for substance use outcomes
Objective This study aims to explore the current practice of risk of bias assessment in systematic r...
Reply to letter to the editor by Peters: Knowledge transfer is the key.
We appreciate Micah Peters’ insightful comments [ [1] Citation of Peters’ letter ...
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