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Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction
Disruption of gamete fusion alters the sperm-egg ratio at gamete interaction
The mechanisms enabling sperm to locate unfertilized eggs within the fallopian tubes remain a subject of debate in reprodu...
Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches
Unraveling the interplay of CD8 + T cells and microRNA signaling in cancer: implications for immune dysfunction and therapeutic approaches
MicroRNAs (miRNAs) emerge as critical regulators of CD8 + T cell function within the complex tumor microenviro...
Microbial and proteomic signatures of type 2 diabetes in an Arab population
Microbial and proteomic signatures of type 2 diabetes in an Arab population
The rising prevalence of Type 2 diabetes mellitus (T2D) in the Qatari population presents a significant public health chal...
Accurate and cost-effective generation of a genetic risk score direct from blood lysates
Accurate and cost-effective generation of a genetic risk score direct from blood lysates
Ethics approval and consent to participate This study was c...
Denosumab in osteoporosis management for diabetes patients: insights from clinical trials and explorations for dual benefit
Denosumab in osteoporosis management for diabetes patients: insights from clinical trials and explorations for dual benefit
Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4....
The role of AMPK in macrophage metabolism, function and polarisation
The role of AMPK in macrophage metabolism, function and polarisation
AMP-activated protein kinase (AMPK) is a ubiquitous sensor of energy and nutritional status in eukaryotic cells. It plays ...
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Ozone alleviates MSU-induced acute gout pain via upregulating AMPK/GAS6/MerTK/SOCS3 signaling pathway
Gout pain seriously affects the quality of patients' life. There is still no effective treatment. The inflammatory res...
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Advancements in engineered mesenchymal stem cell exosomes for chronic lung disease treatment
Chronic lung diseases include an array of conditions that impact airways and lung structures, leading to considerable soci...
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
The epitranscriptome of high-grade gliomas: a promising therapeutic target with implications from the tumor microenvironment to endogenous retroviruses
Glioblastoma (GBM) comprises 45.6% of all primary malignant brain cancers and is one of the most common and aggressive int...
Preliminary analysis of immune-related markers in thymic carcinoid
Preliminary analysis of immune-related markers in thymic carcinoid
The immune-related microenvironment of thymic carcinoid has rarely been reported. We analyzed the expression of PD-L1 and ...
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications
Multifunctional gold nanoparticles for osteoporosis: synthesis, mechanism and therapeutic applications
Osteoporosis is currently the most prevalent bone disorder worldwide and is characterized by low bone mineral density and ...
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
Multiplex immunohistochemistry defines two cholesterol metabolism patterns predicting immunotherapeutic outcomes in gastric cancer
The role of cholesterol metabolism in gastric cancer (GC) and its implications for tumor characteristics and immunotherapy...
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
M-type pyruvate kinase 2 (PKM2) tetramerization alleviates the progression of right ventricle failure by regulating oxidative stress and mitochondrial dynamics
Right ventricle failure (RVF) is a progressive heart disease that has yet to be fully understood at the molecular level. E...
Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
Tri©DB: an integrated platform of knowledgebase and reporting system for cancer precision medicine
With the development of cancer precision medicine, a huge amount of high-dimensional cancer information has rapidly accumu...
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Nicotinamide mononucleotide as a therapeutic agent to alleviate multi-organ failure in sepsis
Sepsis-caused multi-organ failure remains the major cause of morbidity and mortality in intensive care units with limited ...
Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway
Silencing HOXC13 exerts anti-prostate cancer effects by inducing DNA damage and activating cGAS/STING/IRF3 pathway
Advanced prostate cancer (PCa) will develop into castration-resistant prostate cancer (CRPC) and lead to poor prognosis. A...
GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
GATA6-AS1 suppresses epithelial–mesenchymal transition of pancreatic cancer under hypoxia through regulating SNAI1 mRNA stability
Pancreatic ductal adenocarcinoma (PDAC) is characterized by a hypoxic microenvironment, a high rate of heterogeneity as we...
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Endothelial progenitor cells systemic administration alleviates multi-organ senescence by down-regulating USP7/p300 pathway in chronic obstructive pulmonary disease
Chronic obstructive pulmonary disease (COPD) has impacted approximately 390 million people worldwide and the morbidity is ...
Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes
Cucurbitacin E reduces IL-1β-induced inflammation and cartilage degeneration by inhibiting the PI3K/Akt pathway in osteoarthritic chondrocytes
Osteoarthritis is a degenerative joint disease. Cartilage degeneration is the earliest and most important pathological cha...
Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort
Non-invasive biomarkers for early diagnosis of pancreatic cancer risk: metabolite genomewide association study based on the KCPS-II cohort
Pancreatic cancer is a lethal disease with a high mortality rate. The difficulty of early diagnosis is one of its primary ...
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Altered splicing machinery in lung carcinoids unveils NOVA1, PRPF8 and SRSF10 as novel candidates to understand tumor biology and expand biomarker discovery
Lung neuroendocrine neoplasms (LungNENs) comprise a heterogeneous group of tumors ranging from indolent lesions with good ...
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003
ND630 is believed to be a new therapy pharmacologic molecule in targeting the expression of ACACA and regulating the lipid...
The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis
The enrichment of Fanconi anemia/homologous recombination pathway aberrations in ATM/ATR-mutated NSCLC was accompanied by unique molecular features and poor prognosis
ATM and ATR are two critical factors to regulate DNA damage response (DDR), and their mutations were frequently observed i...
A comparative study on ctDNA and tumor DNA mutations in lung cancer and benign cases with a high number of CTCs and CTECs
A comparative study on ctDNA and tumor DNA mutations in lung cancer and benign cases with a high number of CTCs and CTECs
Liquid biopsy provides a non-invasive approach that enables detecting circulating tumor DNA (ctDNA) and circulating tumor ...
TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma
TP53 missense mutation reveals gain-of-function properties in small-sized KRAS transformed pancreatic ductal adenocarcinoma
Although the molecular features of pancreatic ductal adenocarcinoma (PDAC) have been well described, the impact of detaile...
Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells
Tigecycline causes loss of cell viability mediated by mitochondrial OXPHOS and RAC1 in hepatocellular carcinoma cells
Despite recent advances in locoregional, systemic, and novel checkpoint inhibitor treatment, hepatocellular carcinoma (HCC...
A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases
A postmortem case control study of asbestos burden in lungs of malignant mesothelioma cases
Asbestos lung content is regarded as the most reliable tool for causal attribution of malignant mesothelioma (MM) to previ...
A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
A novel complement-fixing IgM antibody targeting GPC1 as a useful immunotherapeutic strategy for the treatment of pancreatic ductal adenocarcinoma
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive cancers with a very low survival rate at 5 ...
The promoting effect and mechanism of MAD2L2 on stemness maintenance and malignant progression in glioma
The promoting effect and mechanism of MAD2L2 on stemness maintenance and malignant progression in glioma
Glioblastoma, the most common primary malignant tumor of the brain, is associated with poor prognosis. Glioblastoma cells ...
hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner
hnRNPA2B1 promotes the occurrence and progression of hepatocellular carcinoma by downregulating PCK1 mRNA via a m6A RNA methylation manner
N6-methyladenosine (m6A) is the most prevalent RNA modification. Although hnRNPA2B1, as a reader of m6A modification, has ...
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