Raič M. Depression and heart diseases: leading health problems. Psychiatr Danub. 2017;4:770–7.

Google Scholar 

Li Z, Li Y, Chen L, Chen P, Hu Y. Prevalence of depression in patients with hypertension: a systematic review and meta-analysis. Medicine. 2015;94:e1317.

CAS  PubMed  PubMed Central  Google Scholar 

GBD 2019 Mental Disorders Collaborators. Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019. Lancet Psychiatry. 2022;9:137–50.

PubMed Central  Google Scholar 

Malhi GS, Mann JJ. Depression. Lancet Lond Engl. 2018;392:2299–312.

Google Scholar 

Johannessen L, Strudsholm U, Foldager L, Munk-Jørgensen P. Increased risk of hypertension in patients with bipolar disorder and patients with anxiety compared to background population and patients with schizophrenia. J Affect Disord. 2006;95:13–7.

PubMed  Google Scholar 

Kretchy IA, Owusu-Daaku FT, Danquah SA. Mental health in hypertension: assessing symptoms of anxiety, depression and stress on anti-hypertensive medication adherence. Int J Ment Health Syst. 2014;8:25.

PubMed  PubMed Central  Google Scholar 

Fan B, Zhao JV. Genetic proxies for antihypertensive drugs and mental disorders: mendelian randomization study in European and East Asian populations. BMC Med. 2024;22:6.

CAS  PubMed  PubMed Central  Google Scholar 

Tanase DM, Gosav EM, Radu S, Ouatu A, Rezus C, Ciocoiu M, et al. Arterial hypertension and interleukins: potential therapeutic target or future diagnostic marker? Int J Hypertens. 2019;2019:3159283.

PubMed  PubMed Central  Google Scholar 

Cruickshank JM. The role of beta-blockers in the treatment of hypertension. Adv Exp Med Biol. 2017;956:149–66.

PubMed  Google Scholar 

Beers MH, Passman LJ. Antihypertensive medications and depression. Drugs. 1990;40:792–9.

CAS  PubMed  Google Scholar 

Nasr SJ, Crayton JW, Agarwal B, Wendt B, Kora R. Lower frequency of antidepressant use in patients on renin-angiotensin-aldosterone system modifying medications. Cell Mol Neurobiol. 2011;31:615–8.

PubMed  PubMed Central  Google Scholar 

Agustini B, Mohebbi M, Woods RL, McNeil JJ, Nelson MR, Shah RC, et al. The association of antihypertensive use and depressive symptoms in a large older population with hypertension living in Australia and the United States: a cross-sectional study. J Hum Hypertens. 2020;34:787–94.

CAS  PubMed  PubMed Central  Google Scholar 

Kessing LV, Rytgaard HC, Ekstrøm CT, Torp-Pedersen C, Berk M, Gerds TA. Antihypertensive drugs and risk of depression: a nationwide Population-Based Study. Hypertens Dallas Tex 1979. 2020;76:1263–79.

CAS  Google Scholar 

Cao YY, Xiang X, Song J, Tian YH, Wang MY, Wang XW, et al. Distinct effects of antihypertensives on depression in the real-world setting: a retrospective cohort study. J Affect Disord. 2019;259:386–91.

CAS  PubMed  Google Scholar 

Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71.

PubMed  PubMed Central  Google Scholar 

Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA. 2000;283:2008–12.

CAS  PubMed  Google Scholar 

Sterne JA, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ. 2016;355:i4919.

PubMed  PubMed Central  Google Scholar 

McGuinness LA, Higgins JPT. Risk-of-bias VISualization (robvis): An R package and Shiny web app for visualizing riskof-bias assessments. Res Syn Meth. 2021;12:55–61.

Cornell JE, Mulrow CD, Localio R, Stack CB, Meibohm AR, Guallar E, et al. Random-effects meta-analysis of inconsistent effects: a time for change. Ann Intern Med. 2014;160:267–70.

PubMed  Google Scholar 

Review Manager (RevMan) [Computer program]. Version 5.4. The Cochrane Collaboration, 2020

Haddaway NR, Page MJ, Pritchard CC, McGuinness LA. PRISMA2020: an R package and Shiny app for producing PRISMA 2020-compliant flow diagrams, with interactivity for optimised digital transparency and Open Synthesis. Campbell Syst Rev. 2022;18:e1230.

PubMed  PubMed Central  Google Scholar 

Zill P, Baghai TC, Schüle C, Born C, Früstück C, Büttner A, et al. DNA methylation analysis of the Angiotensin Converting Enzyme (ACE) gene in major depression. PLOS ONE. 2012;7:e40479.

CAS  PubMed  PubMed Central  Google Scholar 

Bornand D, Reinau D, Jick SS, Meier CR. β-blockers and the risk of depression: a Matched Case-Control Study. Drug Saf. 2022;45:181–9.

CAS  PubMed  PubMed Central  Google Scholar 

Verbeek DEP, van Riezen J, de Boer RA, van Melle JP, de Jonge P. A review on the putative association between beta-blockers and depression. Heart Fail Clin. 2011;7:89–99.

PubMed  Google Scholar 

Poirier L, Tobe SW. Contemporary use of β-blockers: clinical relevance of subclassification. Can J Cardiol. 2014;30:S9–15.

PubMed  Google Scholar 

Riemer TG, Villagomez Fuentes LE, Algharably EAE, Schäfer MS, Mangelsen E, Fürtig MA, et al. Do β-blockers cause depression? Hypertension. 2021;77:1539–48.

CAS  PubMed  Google Scholar 

Li Y, Fan Y, Sun Y, Alolga RN, Xiao P, Ma G. Antihypertensive drug use and the risk of depression: a systematic review and network meta-analysis. Front Pharmacol. 2021;12:777987.

PubMed  PubMed Central  Google Scholar 

Chauquet S, Zhu Z, O’Donovan MC, Walters JTR, Wray NR, Shah S. Association of antihypertensive drug target genes with psychiatric disorders: a mendelian Randomization Study. JAMA Psychiatry. 2021;78:623–31.

PubMed  Google Scholar 

Du XL, Martinez J, Yamal JM, Simpson LM, Davis BR. The 18-year risk of cancer, angioedema, insomnia, depression, and erectile dysfunction in association with antihypertensive drugs: post-trial analyses from ALLHAT-Medicare linked data. Front Cardiovasc Med. 2023;10:1272385.

CAS  PubMed  PubMed Central  Google Scholar 

Lee JM, Choi S, Jeong S, Son JS, Park SJ, Chang J, et al. Distinct effects of angiotensin converting enzyme inhibitors and angiotensin receptor blockers on major depressive disorder: a nationwide cohort study. Asian J Psychiatry. 2023;81:103436.

Google Scholar 

Shaw RJ, Mackay D, Pell JP, Padmanabhan S, Bailey DS, Smith DJ. The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients. Psychol Med. 2021;51:1183–91.

PubMed  Google Scholar 

van Sloten TT, Souverein PC, Stehouwer CD, Driessen JH. Angiotensin-converting enzyme inhibitors and angiotensin receptor blockers and risk of depression among older people with hypertension. J Psychopharmacol Oxf Engl. 2022;36:594–603.

Google Scholar 

Van de Velde S, Bracke P, Levecque K. Gender differences in depression in 23 European countries. Cross-national variation in the gender gap in depression. Soc Sci Med 1982. 2010;71:305–13.

Google Scholar 

Boal AH, Smith DJ, McCallum L, Muir S, Touyz RM, Dominiczak AF, et al. Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders. Hypertens Dallas Tex 1979. 2016;68:1132–8.

CAS  Google Scholar 

Feng L, Tan CH, Merchant RA, Ng TP. Association between depressive symptoms and use of HMG-CoA reductase inhibitors (statins), corticosteroids and histamine H(2) receptor antagonists in community-dwelling older persons: cross-sectional analysis of a population-based cohort. Drugs Aging. 2008;25:795–805.

CAS  PubMed  Google Scholar 

Gammoh O, Bjørk MH, Al Rob OA, AlQudah AR, Hani AB, Al-Smadi A. The association between antihypertensive medications and mental health outcomes among Syrian war refugees with stress and hypertension. J Psychosom Res. 2023;168:111200.

PubMed  Google Scholar 

Gerstman BB, Jolson HM, Bauer M, Cho P, Livingston JM, Platt R. The incidence of depression in new users of beta-blockers and selected antihypertensives. J Clin Epidemiol. 1996;49:809–15.

CAS  PubMed  Google Scholar 

Johansen A, Holmen J, Stewart R, Bjerkeset O. Anxiety and depression symptoms in arterial hypertension: the influence of antihypertensive treatment. the HUNT study, Norway. Eur J Epidemiol. 2012;27:63–72.

CAS  PubMed  Google Scholar 

Michal M, Wiltink J, Lackner K, Wild PS, Zwiener I, Blettner M, et al. Association of hypertension with depression in the community: results from the Gutenberg Health Study. J Hypertens. 2013;31:893–9.

CAS  PubMed  Google Scholar 

Ringoir L, Pedersen SS, Widdershoven JWMG, Pouwer F, Keyzer JML, Romeijnders AC, et al. Beta-blockers and depression in elderly hypertension patients in primary care. Fam Med. 2014;46:447–53.

PubMed  Google Scholar 

Simonson W, Han LF, Davidson HE. Hypertension treatment and outcomes in US nursing homes: results from the US National Nursing Home Survey. J Am Med Dir Assoc. 2011;12:44–9.

PubMed  Google Scholar