Remote ischaemic post conditioning in NE: A feasible and simple paradigm for self-protection in the brain?

Lo, E. et al. Remote ischemic post-conditioning for neonatal encephalopathy: a safety and feasibility trial. Pediatr. Res. https://doi.org/10.1038/s41390-024-03625-2 (2024).

Schreglmann, M., Ground, A., Vollmer, B. & Johnson, M. J. Systematic review: long-term cognitive and behavioural outcomes of neonatal hypoxic-ischaemic encephalopathy in children without cerebral palsy. Acta Paediatr. 109, 20–30 (2020).

Article  PubMed  Google Scholar 

Robertson, N. J. et al. Therapeutic hypothermia for birth asphyxia in low-resource settings: a pilot randomised controlled trial. Lancet 372, 801–803 (2008).

Article  PubMed  Google Scholar 

Thayyil, S. et al. HELIX consortium. Hypothermia for moderate or severe neonatal encephalopathy in low-income and middle-income countries (HELIX): a randomised controlled trial in India, Sri Lanka, and Bangladesh. Lancet Glob. Health 9, e1273–e1285 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Lu, M., Wang, Y., Ren, H., Yin, X. & Li, H. Research progress on the mechanism of action and clinical application of remote ischemic post-conditioning for acute ischemic stroke. Clin. Neurol. Neurosurg. 244, 108397 (2024).

Article  PubMed  Google Scholar 

Murry, C. E., Jennings, R. B. & Reimer, K. A. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation 74, 1124–1136 (1986).

Article  PubMed  CAS  Google Scholar 

Kitagawa, K. et al. Ischemic tolerance’ phenomenon found in the brain. Brain Res 528, 21–24 (1990).

Article  PubMed  CAS  Google Scholar 

Lim, S. Y. & Hausenloy, D. J. Remote ischemic conditioning: from bench to bedside. Front Physiol. 3, 27 (2012).

Article  PubMed  PubMed Central  Google Scholar 

Hess, D. C. et al. Remote ischaemic conditioning-a new paradigm of self-protection in the brain. Nat. Rev. Neurol. 11, 698–710 (2015).

Article  PubMed  CAS  Google Scholar 

Erbil, D. et al. GLP-1’s role in neuroprotection: a systematic review. Brain Inj. 33, 734–819 (2019).

Article  PubMed  Google Scholar 

Imitola, J. et al. Directed migration of neural stem cells to sites of CNS injury by the stromal cell-derived factor 1alpha/CXC chemokine receptor 4 pathway. Proc. Natl Acad. Sci. USA 101, 18117–18122 (2004).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Han, D. et al. Remote Limb Ischemic Postconditioning Protects against Ischemic Stroke via Modulating Microglia/Macrophage Polarization in Mice. J. Immunol. Res. 2021, 6688053 (2021).

Zhou, Y. et al. Remote limb ischemic postconditioning protects against neonatal hypoxic ischemic brain injury in rat pups by the opioid receptor/Akt pathway. Stroke 42, 439–444 (2011).

Article  PubMed  CAS  Google Scholar 

Ren, C. et al. Limb remote ischemic postconditioning protects against focal ischemia in rats. Brain Res. 1288, 88–94 (2009).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ezzati, M. et al. Immediate remote ischemic postconditioning after hypoxia ischemia in piglets protects cerebral white matter but not grey matter. J. Cereb. Blood Flow. Metab. 36, 1396–1411 (2016).

Article  PubMed  CAS  Google Scholar 

Kyng, K. J. Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets. Pediatr. Res. 89, 150–156 (2021).

Article  PubMed  CAS  Google Scholar 

Andelius, T. C. K. et al. No added neuroprotective effect of remote ischemic postconditioning and therapeutic hypothermia after mild hypoxia-ischemia in a piglet model. Front. Pediatr. 26, 299 (2020).

Article  Google Scholar 

Chen, H. S. et al. RICAMIS investigators. effect of remote ischemic conditioning vs usual care on neurologic function in patients with acute moderate ischemic stroke: The RICAMIS randomized clinical trial. JAMA 328, 627–636 (2022).

Article  PubMed  PubMed Central  Google Scholar 

Zhao, W. et al. Remote ischaemic conditioning for preventing and treating ischaemic stroke. Cochrane Database Syst. Rev. 7, CD012503 (2018).

PubMed  Google Scholar 

England, T. J. et al. RECAST (Remote Ischemic Conditioning After Stroke Trial): A pilot randomized placebo controlled Phase II trial in acute ischemic stroke. Stroke 48, 1412–1415 (2017).

Article  PubMed  Google Scholar 

Hodoodi, F. et al. The effect of head cooling and remote ischemic conditioning on patients with traumatic brain injury. iScience 24, 102472 (2021).

Article  PubMed  PubMed Central  CAS  Google Scholar 

Ganji, N. et al. Remote ischemic conditioning in necrotizing enterocolitis. Semin. Pediatr. Surg. 32, 151312 (2023).

Article  PubMed  Google Scholar 

Zozaya, C. et al. Remote ischaemic conditioning in necrotising enterocolitis: a phase I feasibility and safety study. Arch. Dis. Child Fetal Neonatal Ed. 108, 69–76 (2023).

Article  PubMed  Google Scholar 

Fleiss, B. & Gressens, P. Tertiary mechanisms of brain damage: a new hope for treatment of cerebral palsy? Lancet Neurol. 11, 556–566 (2016).

Article  Google Scholar 

Li, Q. et al. Remote ischemic conditioning with medical management or reperfusion therapy for acute ischemic stroke: a systematic review and meta-analysis. Neurology 102, e207983 (2024).

Article  PubMed  CAS  Google Scholar 

Kharbanda, R. K. et al. Transient limb ischemia induces remote ischemic preconditioning in vivo. Circulation 106, 2881–2883 (2002).

Article  PubMed  CAS  Google Scholar 

Comments (0)

No login
gif