Clinical Utility of Sperm Function Tests in Predicting Male Fertility: A Systematic Review

Mann U, Shiff B, Patel P. Reasons for worldwide decline in male fertility. Curr Opin Urol. 2020;30(3):296–301. https://doi.org/10.1097/MOU.0000000000000745.

Article  PubMed  Google Scholar 

Sharlip ID, Jarow JP, Belker AM, Lipshultz LI, Sigman M, Thomas AJ, Schlegel PN, Howards SS, Nehra A, Damewood MD, Overstreet JW, Sadovsky R. Best practice policies for male infertility. Fertil Steril. 2002;77(5):873–82. https://doi.org/10.1016/s0015-0282(02)03105-9.

Article  PubMed  Google Scholar 

Kumar N, Singh AK. Trends of male factor infertility, an important cause of infertility: a review of literature. J Hum Reprod Sci. 2015;8(4):191–6. https://doi.org/10.4103/0974-1208.170370.

Article  PubMed  PubMed Central  Google Scholar 

Esteves SC. Novel concepts in male factor infertility: clinical and laboratory perspectives. J Assist Reprod Genet. 2016;33(10):1319–35. https://doi.org/10.1007/s10815-016-0763-8.

Krzastek SC, Farhi J, Gray M, Smith RP. Impact of environmental toxin exposure on male fertility potential. Transl Androl Urol. 2020;9(6):2797–813. https://doi.org/10.21037/tau-20-685.

Article  PubMed  PubMed Central  Google Scholar 

Durairajanayagam D, Singh D, Agarwal A, Henkel R. Causes and consequences of sperm mitochondrial dysfunction. Andrologia. 2021 Feb;53(1):e13666. https://doi.org/10.1111/and.13666.

Article  CAS  PubMed  Google Scholar 

Arya D, Balasinor N, Singh D. Varicocoele-associated male infertility: cellular and molecular perspectives of pathophysiology. Andrology. 2022;10(8):1463–83. https://doi.org/10.1111/andr.13278.

Article  CAS  PubMed  Google Scholar 

Esteves SC. Clinical relevance of routine semen analysis and controversies surrounding the 2010 World Health Organization criteria for semen examination. Int Braz J Urol. 2014;40(4):443–53. https://doi.org/10.1590/S1677-5538.IBJU.2014.04.02.

Article  PubMed  Google Scholar 

Vasan SS. Semen analysis and sperm function tests: how much to test? Indian J Urol. 2011 Jan;27(1):41–8. https://doi.org/10.4103/0970-1591.78424.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Björndahl L. O-285 The 6th edition of the WHO manual for the examination and processing of human semen: how should it affect our practice? Human Reproduction. 2023;38(Supplement_1):dead093-345.

Douglas C, Parekh N, Kahn LG, Henkel R, Agarwal A. A novel approach to improving the reliability of manual semen analysis: a paradigm shift in the workup of infertile men. World J Mens Health. 2021;39(2):172–85. https://doi.org/10.5534/wjmh.190088.

Article  PubMed  Google Scholar 

Moody MA, Cardona C, Simpson AJ, Smith TT, Travis AJ, Ostermeier GC. Validation of a laboratory-developed test of human sperm capacitation. Mol Reprod Dev. 2017;84(5):408–22. https://doi.org/10.1002/mrd.22801.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Matamoros-Volante A, Moreno-Irusta A, Torres-Rodriguez P, Giojalas L, Gervasi MG, Visconti PE, Treviño CL. Semi-automatized segmentation method using image-based flow cytometry to study sperm physiology: the case of capacitation-induced tyrosine phosphorylation. Mol Hum Reprod. 2018;24(2):64–73.

Article  CAS  PubMed  Google Scholar 

Liu DY, Baker HW. A simple method for assessment of the human acrosome reaction of spermatozoa bound to the zona pellucida: lack of relationship with ionophore A23187-induced acrosome reaction. Hum Reprod. 1996;11(3):551–7. https://doi.org/10.1093/humrep/11.3.551.

Article  CAS  PubMed  Google Scholar 

Oehninger S, Morshedi M, Franken D. The hemizona assay for assessment of sperm function. Methods Mol Biol. 2013;927:91–102. https://doi.org/10.1007/978-1-62703-038-0_9.

Article  CAS  PubMed  Google Scholar 

Glazier DB, Marmar JL, Diamond SM, Gibbs M, Corson SL. A modified acrosome induction test. Arch Androl. 2000;44(1):59–64. https://doi.org/10.1080/014850100262425.

Article  CAS  PubMed  Google Scholar 

Carver-Ward JA, Jaroudi KA, Hollanders JM, Einspenner M. High fertilization prediction by flow cytometric analysis of the CD46 antigen on the inner acrosomal membrane of spermatozoa. Hum Reprod. 1996;11(9):1923–8. https://doi.org/10.1093/oxfordjournals.humrep.a019518.

Article  CAS  PubMed  Google Scholar 

Oehninger S, Coddington CC, Scott R, Franken DA, Burkman LJ, Acosta AA, Hodgen GD. Hemizona assay: assessment of sperm dysfunction and prediction of in vitro fertilization outcome. Fertil Steril. 1989;51(4):665–70. https://doi.org/10.1016/s0015-0282(16)60618-0.

Article  CAS  PubMed  Google Scholar 

Gorczyca W, Bruno S, Darzynkiewicz R, Gong J, Darzynkiewicz Z. DNA strand breaks occurring during apoptosis—their early insitu detection by the terminal deoxynucleotidyl transferase and nick translation assays and prevention by serine protease inhibitors. Int J Oncol. 1992;1:639–48. https://doi.org/10.3892/ijo.1.6.639.

Article  CAS  PubMed  Google Scholar 

Sharma R, Ahmad G, Esteves SC, Agarwal A. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay using bench top flow cytometer for evaluation of sperm DNA fragmentation in fertility laboratories: protocol, reference values, and quality control. J Assist Reprod Genet. 2016 Feb;33(2):291–300. https://doi.org/10.1007/s10815-015-0635-7.

Article  PubMed  PubMed Central  Google Scholar 

Ostling O, Johanson KJ. Microelectrophoretic study of radiation-induced DNA damages in individual mammalian cells. Biochem Biophys Res Commun. 1984;123(1):291–8. https://doi.org/10.1016/0006-291x(84)90411-x.

Article  CAS  PubMed  Google Scholar 

Bungum M, Humaidan P, Spano M, Jepson K, Bungum L, Giwercman A. The predictive value of sperm chromatin structure assay (SCSA) parameters for the outcome of intrauterine insemination. IVF and ICSI. Hum Reprod. 2004;19(6):1401–8. https://doi.org/10.1093/humrep/deh280.

Article  CAS  PubMed  Google Scholar 

Fernández JL, Muriel L, Rivero MT, Goyanes V, Vazquez R, Alvarez JG. The sperm chromatin dispersion test: a simple method for the determination of sperm DNA fragmentation. J Androl. 2003 Jan-Feb;24(1):59–66.

Article  PubMed  Google Scholar 

Erenpreiss J, Jepson K, Giwercman A, Tsarev I, Erenpreisa J, Spano M. Toluidine blue cytometry test for sperm DNA conformation: comparison with the flow cytometric sperm chromatin structure and TUNEL assays. Hum Reprod. 2004;19(10):2277–82. https://doi.org/10.1093/humrep/deh417.

Article  CAS  PubMed  Google Scholar 

Panner Selvam MK, Agarwal A. A systematic review on sperm DNA fragmentation in male factor infertility: laboratory assessment. Arab J Urol. 2018;16(1):65–76. https://doi.org/10.1016/j.aju.2017.12.001.

Article  PubMed  PubMed Central  Google Scholar 

Gopalkrishnan K, Hinduja IN, Kumar TC. In vitro decondensation of nuclear chromatin of human spermatozoa: assessing fertilizing potential. Arch Androl. 1991;27(1):43–50. https://doi.org/10.3109/01485019108987650.

Article  CAS  PubMed  Google Scholar 

Carreras A, Ramirez JP, Mendoza C. Sperm plasma membrane integrity measurement: a combined method. Andrologia. 1992;24(6):335–40. https://doi.org/10.1111/j.1439-0272.1992.tb02665.x.

Article  CAS  PubMed  Google Scholar 

Rumke PH. The presence of sperm antibodies in the serum of two patients with oligospermia. Vox Sang. 1954;4:135–40.

Google Scholar 

Andolz P, Bielsa MA, Martínez P, García-Framis V, Benet-Rubinat JM, Egozcue J. Detection of anti-sperm antibodies in serum, seminal plasma and cervical mucus by the immunobead test. Hum Reprod. 1990;5(6):685–9. https://doi.org/10.1093/oxfordjournals.humrep.a137168.

Article  CAS  PubMed  Google Scholar 

De Almeida M, Soumah A, Jouannet P. Incidence of sperm-associated immunoglobulins in infertile men with suspected autoimmunity to sperm. Int J Androl. 1986;9(5):321–30. https://doi.org/10.1111/j.1365-2605.1986.tb00894.x.

Article  PubMed  Google Scholar 

Marques M, Sousa AP, Paiva A, Almeida-Santos T, Ramalho-Santos J. Low amounts of mitochondrial reactive oxygen species define human sperm quality. Reproduction. 2014;147(6):817–24. https://doi.org/10.1530/REP-13-0644.

Article  CAS  PubMed  Google Scholar 

Eruslanov E, Kusmartsev S. Identification of ROS using oxidized DCFDA and flow-cytometry. Methods Mol Biol. 2010;594:57–72. https://doi.org/10.1007/978-1-60761-411-1_4.

Article  CAS  PubMed  Google Scholar 

Royall JA, Ischiropoulos H. Evaluation of 2',7'-dichlorofluorescin and dihydrorhodamine 123 as fluorescent probes for intracellular H2O2 in cultured endothelial cells. Arch Biochem Biophys. 1993;302(2):348–55. https://doi.org/10.1006/abbi.1993.1222.

Article  CAS  PubMed  Google Scholar 

Chai RR, Chen GW, Shi HJ, WS O, Martin-DeLeon PA, Chen H. Prohibitin involvement in the generation of mitochondrial superoxide at complex I in human sperm. J Cell Mol Med. 2017, 21(1):121–9. https://doi.org/10.1111/jcmm.12945.

Ashar FN, Zhang Y, Longchamps RJ, Lane J, Moes A, Grove ML, Mychaleckyj JC, Taylor KD, Coresh J, Rotter JI, Boerwinkle E, Pankratz N, Guallar E, Arking DE. Association of mitochondrial DNA copy number with cardiovascular disease. JAMA Cardiol. 2017;2(11):1247–55. https://doi.org/10.1001/jamacardio.2017.3683.

Article  PubMed  PubMed Central  Google Scholar 

Li B, Kaushik S, Kalinowski P, Kim B, Gershome C, Ching J, Poburko D. Droplet digital PCR shows the D-Loop to be an error prone locus for mitochondrial DNA copy number determination. Sci Rep. 2018;8(1):11392. https://doi.org/10.1038/s41598-018-29621-1.

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