Preventive Anti-inflammatory Effects of Apocynin on Acetic Acid–Induced Colitis in Rats

Hamanaka, Robert B., and Navdeep S. Chandel. 2010. Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes. Trends in Biochemical Sciences 35 (9): 505–513. https://doi.org/10.1016/j.tibs.2010.04.002.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Ohashi, Masuo, Marschall S. Runge, Frank M. Faraci, and Donald D. Heistad. 2006. MnSOD deficiency increases endothelial dysfunction in ApoE-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology 26 (10): 2331–2336. https://doi.org/10.1161/01.ATV.0000238347.77590.c9.

Article  CAS  PubMed  Google Scholar 

Franco, Rodrigo, Onard Schoneveld, Alexandros G. Georgakilas, and Mihalis I. Panayiotidis. 2008. Oxidative stress, DNA methylation and carcinogenesis. Cancer Letters 266 (1): 6–11. https://doi.org/10.1016/j.canlet.2008.02.026.

Article  CAS  PubMed  Google Scholar 

Kouki, Ahmed, Wafa Ferjani, Néziha. Ghanem-Boughanmi, Mossadok Ben-Attia, Pham My-Chan. Dang, Abdelaziz Souli, and Jamel El-Benna. 2023. The NADPH oxidase inhibitors apocynin and diphenyleneiodonium protect rats from LPS-induced pulmonary inflammation. Antioxidants (Basel, Switzerland) 12 (3): 770. https://doi.org/10.3390/antiox12030770.

Article  CAS  PubMed  Google Scholar 

Zhu, Hong, and Y. Robert Li. 2012. Oxidative stress and redox signaling mechanisms of inflammatory bowel disease: Updated experimental and clinical evidence. Experimental biology and Medicine (Maywood, N.J.) 237(5): 474–480. https://doi.org/10.1258/ebm.2011.011358.

Okur, Hamit, Mustafa Küçükaydin, Kader Köse, Olgun Kontaş, Pakize Doǧan, and Ahmet Kazez. 1995. Hypoxia-induced necrotizing enterocolitis in the immature rat: The role of lipid peroxidation and management by vitamin E. Journal of Pediatric Surgery 30 (10): 1416–1419. https://doi.org/10.1016/0022-3468(95)90395-x.

Article  CAS  PubMed  Google Scholar 

Bitton, Alain, Mark A. Peppercorn, Donald A. Antonioli, John L. Niles, Samir Shah, Athos Bousvaros, Bernard Ransil, Bernard Wild, Gary Cohen, Albert Deb Edwardes, Michael D. Stevens, and C. Anthony. 2001. Clinical, biological, and histologic parameters as predictors of relapse in ulcerative colitis. Gastroenterology 120 (1): 13–20. https://doi.org/10.1053/gast.2001.20912.

Article  CAS  PubMed  Google Scholar 

Oshitani, Nobuhide, Yoshinori Sawa, Junichi Hara, Kenji Adachi, Shiro Nakamura, Takayuki Matsumoto, Tetsuo Arakawa, and Tetsuo Kuroki. 1997. Functional and phenotypical activation of leucocytes in inflamed human colonic mucosa. Journal of Gastroenterology and Hepatology 12 (12): 809–814. https://doi.org/10.1111/j.1440-1746.1997.tb00376.x.

Article  CAS  PubMed  Google Scholar 

Guan, Qingdong, and Jiguo Zhang. 2017. Recent advances: The imbalance of cytokines in the pathogenesis of inflammatory bowel disease. Mediators of Inflammation 2017: 4810258. https://doi.org/10.1155/2017/4810258.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Fridovich, Irwin. 2004. Mitochondria: Are they the seat of senescence? Aging Cell 3 (1): 13–16. https://doi.org/10.1046/j.1474-9728.2003.00075.x.

Article  CAS  PubMed  Google Scholar 

Spiekermann, Stephan, Ulf Landmesser, Sergey Dikalov, Martin Bredt, Graciela Gamez, Helma Tatge, Nina Reepschläger, Burkhard Hornig, Helmut Drexler, and David G. Harrison. 2003. Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: Relation to endothelium-dependent vasodilation. Circulation 107 (10): 1383–1389. https://doi.org/10.1161/01.cir.0000056762.69302.46.

Article  CAS  PubMed  Google Scholar 

Bedard, Karen, and Karl-Heinz. Krause. 2007. The NOX family of ROS-generating NADPH oxidases: Physiology and pathophysiology. Physiological Reviews 87 (1): 245–313. https://doi.org/10.1152/physrev.00044.2005.

Article  CAS  PubMed  Google Scholar 

Lambeth, J. David. 2007. Nox enzymes, ROS, and chronic disease: An example of antagonistic pleiotropy. Free radical Biology & Medicine 43 (3): 332–347. https://doi.org/10.1016/j.freeradbiomed.2007.03.027.

Article  CAS  Google Scholar 

Bhattacharyya, Asima, Ranajoy Chattopadhyay, Sankar Mitra, and Sheila E. Crowe. 2014. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiological Reviews 94 (2): 329–354. https://doi.org/10.1152/physrev.00040.2012.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Baumgart, Daniel C., and William J. Sandborn. 2007. Inflammatory bowel disease: Clinical aspects and established and evolving therapies. Lancet (London, England) 369 (9573): 1641–1657. https://doi.org/10.1016/S0140-6736(07)60751-X.

Article  CAS  PubMed  Google Scholar 

Hamouda, Hala E., Soha S. Zakaria, Saber A. Ismail, Mahmoud A. Khedr, and Wael W. Mayah. 2011. p53 antibodies, metallothioneins, and oxidative stress markers in chronic ulcerative colitis with dysplasia. World Journal of Gastroenterology 17 (19): 2417–2423. https://doi.org/10.3748/wjg.v17.i19.2417.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Wu, Chia-Chao, Jin-Shuen Chen, Wen-Mein Wu, Tung-Nan Liao, Pauling Chu, Shih-Hua Lin, Chien-Huei Chuang, and Yuh-Feng Lin. 2005. Myeloperoxidase serves as a marker of oxidative stress during single haemodialysis session using two different biocompatible dialysis membranes. Nephrology, Dialysis, Transplantation 20 (6): 1134–1139. https://doi.org/10.1093/ndt/gfh764.

Beltran, Belen, Pilar Nos, Francisco Dasí, Marisa Iborra, Guillermo Bastida, Marcial Martínez, José-Enrique. O’Connor, Guillermo Sáez, Inés. Moret, and Julio Ponce. 2010. Mitochondrial dysfunction, persistent oxidative damage, and catalase inhibition in immune cells of naïve and treated Crohn’s disease. Inflammatory Bowel Diseases 16 (1): 76–86. https://doi.org/10.1002/ibd.21027.

Article  PubMed  Google Scholar 

Neurath, Markus F., Ivan Fuss, Guido Schürmann, Sven Pettersson, H.E.L.M.U.T. Karl Arnold, Warren Strober Müller-Lobeck, Christian Herfarth, and Karl-Hermann Meyer Zum. Büschenfelde. 1998. Cytokine gene transcription by NF-kappa B family members in patients with inflammatory bowel disease. Annals of the New York Academy of Sciences 859: 149–159. https://doi.org/10.1111/j.1749-6632.1998.tb11119.x.

Article  CAS  PubMed  Google Scholar 

Altenhöfer, Sebastian, Kim A. Radermacher, Pamela WM. Kleikers, Kirstin Wingler, and Harald HHW. Schmidt. 2015. Evolution of NADPH oxidase inhibitors: Selectivity and mechanisms for target engagement. Antioxidants & Redox Signaling 23 (5): 406–427. https://doi.org/10.1089/ars.2013.5814.

Article  CAS  Google Scholar 

Probert, Chris. 2013. Steroids and 5-aminosalicylic acids in moderate ulcerative colitis: Addressing the dilemma. Therapeutic Advances in Gastroenterology 6 (1): 33–38. https://doi.org/10.1177/1756283X12461395.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Roselli, Marianna, and Alberto Finamore. 2020. Use of synbiotics for ulcerative colitis treatment. Current Clinical Pharmacology 15 (3): 174–182. https://doi.org/10.2174/1574884715666191226120322.

Article  CAS  PubMed  Google Scholar 

Feagan, Brian G., and John K. MacDonald. 2012. Oral 5-aminosalicylic acid for induction of remission in ulcerative colitis. The Cochrane Database of Systematic Reviews 10: CD000543. https://doi.org/10.1002/14651858.CD000543.pub3.

Ford, A.C., C.N. Bernstein, K.J. Khan, M.T. Abreu, J.K. Marshall, N.J. Talley, and P. Moayyedi. 2011. Glucocorticosteroid therapy in inflammatory bowel disease: Systematic review and meta-analysis. The American Journal of Gastroenterology 106 (4): 590–600. https://doi.org/10.1038/ajg.2011.70.

Article  CAS  PubMed  Google Scholar 

Singh, Amandeep, Kirandeep Kaur, Veerpal Kaur, Gurmeet Singh, Uttam Kumar Mandal, Neeraj Mishra, and Raj Kumar Narnag. 2019. Importance of nanocarriers and probiotics in the treatment of ulcerative colitis. Journal of Drug Delivery and Therapeutics 9: 216–228.

Article  CAS  Google Scholar 

Newman, David J., and Gordon M. Cragg. 2020. Natural products as sources of new drugs over the nearly four decades from 01/1981 to 09/2019. Journal of Natural Products 83 (3): 770–803. https://doi.org/10.1021/acs.jnatprod.9b01285.

Article  CAS  PubMed  Google Scholar 

Johnson, David K., Kurt J. Schillinger, David M. Kwait, Chambers V. Hughes, Erin J. McNamara, Fauod Ishmael, Robert W. O'Donnell, Ming-Mei Chang, Michael G. Hogg, Jonathan S. Dordick, Lakshmi Santhanam, Linda M. Ziegler and James A. Holland. 2002. Inhibition of NADPH oxidase activation in endothelial cells by ortho-methoxy-substituted catechols. Endothelium: Journal of Endothelial Cell Research 9 (3): 191–203. https://doi.org/10.1080/10623320213638.

Vejražka, Martin, Radan Míček, and Stanislav Štípek. 2005. Apocynin inhibits NADPH oxidase in phagocytes but stimulates ROS production in non-phagocytic cells. Biochimica et biophysica acta 1722 (2): 143–147. https://doi.org/10.1016/j.bbagen.2004.12.008.

Article  CAS  PubMed  Google Scholar 

Hur, Jinyoung, Pyeongjae Lee, Mi Jung Kim, Younghoon Kim, and Young-Wuk Cho. 2010. Ischemia-activated microglia induces neuronal injury via activation of gp91phox NADPH oxidase. Biochemical and Biophysical Research Communications 391 (3): 1526–1530. https://doi.org/10.1016/j.bbrc.2009.12.114.

Muijsers, R.B.R., E. van Den Worm, G. Folkerts, C.J. Beukelman, A.S. Koster, D.S. Postma, and F.P. Nijkamp. 2000. Apocynin inhibits peroxynitrite formation by murine macrophages. British Journal of Pharmacology 130 (4): 932–936. https://doi.org/10.1038/sj.bjp.0703401.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Hougee, Sander, Anita Hartog, Annemarie Sanders, Yvo MF. Graus, Maarten A. Hoijer, Johan Garssen, Wim B. van den Berg, Henk M. van Beuningen, and H. Friso Smit. 2006. Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice. European Journal of Pharmacology 531 (1–3): 264–269. https://doi.org/10.1016/j.ejphar.2005.11.061.

Article  CAS  PubMed  Google Scholar 

Marín, Marta, Rosa María Giner, José-Luis. Ríos, and María del Carmen Recio. 2013. Protective effect of apocynin in a mouse model of chemically-induced colitis. Planta Medica 79 (15): 1392–1400. https://doi.org/10.1055/s-0033-1350710.

Article  CAS  PubMed  Google Scholar 

Stefanska, J., and R. Pawliczak. 2008. Apocynin: Molecular aptitudes. Mediators of Inflammation 2008: 106507. https://doi.org/10.1155/2008/106507.

Article  CAS  PubMed  PubMed Central  Google Scholar 

Simons, Jos M., Bert A't Hart, Theo RAM Ip Vai Ching, Hans Van Dijk, and Rudi P. Labadie. 1990. Metabolic activation of natural phenols into selective oxidative burst agonists by activated human neutrophils. Free Radical Biology & Medicine 8 (3): 251–258. https://doi.org/10.1016/0891-5849(90)90070-y.

Müller, Andreas A., Susanne A. Reiter, Karin G. Heider, and Hildebert Wagner. 1999. Plant-derived acetophenones with antiasthmatic and anti-inflammatory properties: Inhibitory effects on chemotaxis, right angle light scatter and actin polymerization of polymorphonuclear granulocytes. Planta Medica 65 (7): 590–594.

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