Abbasi M, Mousavi MJ, Jamalzehi S, Alimohammadi R, Bezvan MH, Mohammadi H, Aslani S (2019) Strategies toward rheumatoid arthritis therapy; the old and the new. J Cell Physiol 234:10018–10031
Article CAS PubMed Google Scholar
Ahmad B, Rehman MU, Amin I, Arif A, Rasool S, Bhat SA, Afzal I, Hussain I, Bilal S, Mir M (2015) A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone). Sci World J 2015:816364
Ahmad B, Rehman MU, Amin I, Mir MUR, Ahmad SB, Farooq A, Muzamil S, Hussain I, Masoodi M, Fatima B (2018) Zingerone (4-(4-hydroxy-3-methylphenyl) butan-2-one) protects against alloxan-induced diabetes via alleviation of oxidative stress and inflammation: Probable role of NF-kB activation. Saudi Pharm J 26:1137–1145
Article PubMed PubMed Central Google Scholar
Al Maashari R, Hamodat MM (2016) Methotrexate-induced panniculitis in a patient with rheumatoid arthritis. Acta Dermatovenerol Alp Pannonica Adriat 25:79–81
Aryaeian N, Mahmoudi M, Shahram F, Poursani S, Jamshidi F, Tavakoli H (2019) The effect of ginger supplementation on IL2, TNFalpha, and IL1beta cytokines gene expression levels in patients with active rheumatoid arthritis: A randomized controlled trial. Med J Islam Repub Iran 33:154
PubMed PubMed Central Google Scholar
Bashir N, Ahmad SB, Rehman MU, Muzamil S, Bhat RR, Mir MUR, Shazly GA, Ibrahim MA, Elossaily GM, Sherif AY et al (2021) Zingerone (4-(four-hydroxy-3-methylphenyl) butane-two-1) modulates adjuvant-induced rheumatoid arthritis by regulating inflammatory cytokines and antioxidants. Redox Rep 26:62–70
Article CAS PubMed PubMed Central Google Scholar
Bischoff-Kont I, Furst R (2021) Benefits of ginger and its constituent 6-shogaol in inhibiting inflammatory processes. Pharmaceuticals (Basel) 14(6):571
Article CAS PubMed Google Scholar
Bottini N, Firestein GS (2013) Duality of fibroblast-like synoviocytes in RA: passive responders and imprinted aggressors. Nat Rev Rheumatol 9:24–33
Article CAS PubMed Google Scholar
Cavalli G, Dinarello CA (2018) Anakinra Therapy for Non-cancer Inflammatory Diseases. Front Pharmacol 9:1157
Article CAS PubMed PubMed Central Google Scholar
Choi JS, Ryu J, Bae WY, Park A, Nam S, Kim JE, Jeong JW (2018) Zingerone suppresses tumor development through decreasing cyclin D1 expression and inducing mitotic arrest. Int J Mol Sci 19(9):2832
Article PubMed PubMed Central Google Scholar
Fang Q, Zhou C, Nandakumar KS (2020) Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis. Mediat Inflamm 2020:3830212
Guo Q, Wang Y, Xu D, Nossent J, Pavlos NJ, Xu J (2018a) Rheumatoid arthritis: pathological mechanisms and modern pharmacologic therapies. Bone Res 6:15
Article PubMed PubMed Central Google Scholar
Guo X, Zhang D, Zhang X, Jiang J, Xue P, Wu C, Zhang J, Jin G, Huang Z, Yang J et al (2018b) Dyrk1A promotes the proliferation, migration and invasion of fibroblast-like synoviocytes in rheumatoid arthritis via down-regulating Spry2 and activating the ERK MAPK pathway. Tissue Cell 55:63–70
Article CAS PubMed Google Scholar
He J, Li X, Wang Z, Bennett S, Chen K, Xiao Z, Zhan J, Chen S, Hou Y, Chen J et al (2019) Therapeutic Anabolic and Anticatabolic Benefits of Natural Chinese Medicines for the Treatment of Osteoporosis. Front Pharmacol 10:1344
Article CAS PubMed PubMed Central Google Scholar
Hemalatha KL, Stanely Mainzen Prince P (2015) Antihyperlipidaemic, antihypertrophic, and reducing effects of zingerone on experimentally induced myocardial infarcted rats. J Biochem Mol Toxicol 29:182–188
Article CAS PubMed Google Scholar
Ilchovska DD, Barrow DM (2021) An Overview of the NF-kB mechanism of pathophysiology in rheumatoid arthritis, investigation of the NF-kB ligand RANKL and related nutritional interventions. Autoimmun Rev 20:102741
Article CAS PubMed Google Scholar
Kim JW, Kim YY, Lee H, Park SH, Kim SK, Choe JY (2017) Risk of Retinal Toxicity in Longterm Users of Hydroxychloroquine. J Rheumatol 44:1674–1679
Article CAS PubMed Google Scholar
Kim MK, Chung SW, Kim DH, Kim JM, Lee EK, Kim JY, Ha YM, Kim YH, No JK, Chung HS et al (2010) Modulation of age-related NF-kappaB activation by dietary zingerone via MAPK pathway. Exp Gerontol 45:419–426
Article CAS PubMed Google Scholar
Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, Korb A, Schnaker EM, Tarner IH, Robbins PD et al (2009) Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 15:1414–1420
Article CAS PubMed PubMed Central Google Scholar
Li H, Wan A (2013) Apoptosis of rheumatoid arthritis fibroblast-like synoviocytes: possible roles of nitric oxide and the thioredoxin 1. Mediat Inflamm 2013:953462
Li J, Pang J, Liu Z, Ge X, Zhen Y, Jiang CC, Liu Y, Huo Q, Sun Y, Liu H (2021) Shikonin induces programmed death of fibroblast synovial cells in rheumatoid arthritis by inhibiting energy pathways. Sci Rep 11:18263
Article CAS PubMed PubMed Central Google Scholar
Liu M, Zhou X, Zhou L, Liu Z, Yuan J, Cheng J, Zhao J, Wu L, Li H, Qiu H et al (2018a) Carnosic acid inhibits inflammation response and joint destruction on osteoclasts, fibroblast-like synoviocytes, and collagen-induced arthritis rats. J Cell Physiol 233:6291–6303
Article CAS PubMed Google Scholar
Liu Z, Zhou L, Ma X, Sun S, Qiu H, Li H, Xu J, Liu M (2018b) Inhibitory effects of tubeimoside I on synoviocytes and collagen-induced arthritis in rats. J Cell Physiol 233:8740–8753
Article CAS PubMed Google Scholar
Masoumi M, Bashiri H, Khorramdelazad H, Barzaman K, Hashemi N, Sereshki HA, Sahebkar A, Karami J (2021) Destructive Roles of Fibroblast-like Synoviocytes in Chronic Inflammation and Joint Damage in Rheumatoid Arthritis. Inflammation 44:466–479
Article CAS PubMed Google Scholar
McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205–2219
Article CAS PubMed Google Scholar
Monge P, Scheline R, Solheim E (1976) The metabolism of zingerone, a pungent principle of ginger. Xenobiotica 6:411–423
Article CAS PubMed Google Scholar
Nygaard G, Firestein GS (2020a) Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol 16:316–333
Article PubMed PubMed Central Google Scholar
Nygaard G, Firestein GS (2020b) Restoring synovial homeostasis in rheumatoid arthritis by targeting fibroblast-like synoviocytes. Nat Rev Rheumatol 16:316–333
Article PubMed PubMed Central Google Scholar
Ostensen M (1992) Treatment with immunosuppressive and disease modifying drugs during pregnancy and lactation. Am J Reprod Immunol 28:148–152
Article CAS PubMed Google Scholar
Qiu H, Sun S, Ma X, Cui C, Chen G, Liu Z, Li H, Liu M (2018) Jatrorrhizine hydrochloride suppresses proliferation, migration, and secretion of synoviocytes in vitro and ameliorates rat models of rheumatoid arthritis in vivo. Int J Mol Sci 19(5):1514
Article PubMed PubMed Central Google Scholar
Rajan I, Narayanan N, Rabindran R, Jayasree PR, Manish Kumar PR (2013) Zingerone protects against stannous chloride-induced and hydrogen peroxide-induced oxidative DNA damage in vitro. Biol Trace Elem Res 155:455–459
Article CAS PubMed Google Scholar
Schett G, Tohidast-Akrad M, Smolen JS, Schmid BJ, Steiner CW, Bitzan P, Zenz P, Redlich K, Xu Q, Steiner G (2000) Activation, differential localization, and regulation of the stress-activated protein kinases, extracellular signal-regulated kinase, c-JUN N-terminal kinase, and p38 mitogen-activated protein kinase, in synovial tissue and cells in rheumatoid arthritis. Arthritis Rheum 43:2501–2512
Article CAS PubMed Google Scholar
Vaibhav K, Shrivastava P, Tabassum R, Khan A, Javed H, Ahmed ME, Islam F, Safhi MM, Islam F (2013) Delayed administration of zingerone mitigates the behavioral and histological alteration via repression of oxidative stress and intrinsic programmed cell death in focal transient ischemic rats. Pharmacol Biochem Behav 113:53–62
Article CAS PubMed Google Scholar
van Breukelen-van der Stoep DF, Klop B, van Zeben D, Hazes JM, Castro Cabezas M (2013) Cardiovascular risk in rheumatoid arthritis: how to lower the risk? Atherosclerosis 231:163–172
Wang T, Liu Q, Tjhioe W, Zhao J, Lu A, Zhang G, Tan RX, Zhou M, Xu J, Feng HT (2017) Therapeutic Potential and Outlook of Alternative Medicine for Osteoporosis. Curr Drug Targets 18:1051–1068
Article CAS PubMed Google Scholar
Wruck CJ, Fragoulis A, Gurzynski A, Brandenburg LO, Kan YW, Chan K, Hassenpflug J, Freitag-Wolf S, Varoga D, Lippross S et al (2011) Role of oxidative stress in rheumatoid arthritis: insights from the Nrf2-knockout mice. Ann Rheum Dis 70:844–850
Comments (0)